CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin

Chemosphere, Journal Year: 2022, Volume and Issue: 306, P. 135578 - 135578

Published: July 4, 2022

Language: Английский

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Metallic and non-metallic nanoparticles from plant, animal, and fisheries wastes: potential and valorization for application in agriculture

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(54), P. 81130 - 81165

Published: Oct. 7, 2022

Language: Английский

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PINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: March 19, 2022

Abstract Copper oxide nanoparticles (CuONPs) are widely used metal NPs owing to their excellent physical–chemical properties. Circulation translocation of CuONPs after inhalation leads vascular endothelial injury. Mitochondria, an important regulatory hub for maintaining cell functions, signaling organelles in responses NPs-induced However, how mitochondrial dynamics (fission and fusion) mitophagy (an autophagy process degrade damaged mitochondria) elaborately orchestrated maintain homeostasis CuONPs-induced injury is still unclear. In this study, we demonstrated that exposure disturbed through oxidative stress-dependent manner cells, as evidenced by the increase fission accumulation fragmented mitochondria. Inhibition with Mdivi-1 aggravated mtROS production death. Furthermore, found led activation PINK1-mediated mitophagy, pharmacological inhibition wortmannin, chloroquine or genetical siRNA-mediated knockdown PINK1 profoundly repressed suggesting protective role toxicity. Intriguingly, identified TAX1BP1 was primary receptor link ubiquitinated mitochondria autophagosomes, since elevated production, decreased clearance cells More importantly, verified urolithin A, a activator, promoted removal induced both vitro vivo. Overall, our findings indicated modulating may be therapeutic strategy pathological caused exposure. Graphical

Language: Английский

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Functional nanomaterials and their potentials in antibacterial treatment of dental caries

Colloids and Surfaces B Biointerfaces, Journal Year: 2022, Volume and Issue: 218, P. 112761 - 112761

Published: Aug. 6, 2022

Language: Английский

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Bioproduction and applications of short-chain fatty acids from secondary sludge anaerobic fermentation: A critical review

Renewable and Sustainable Energy Reviews, Journal Year: 2023, Volume and Issue: 183, P. 113502 - 113502

Published: July 7, 2023

Language: Английский

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