Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Vascular
aging
and
its
associated
diseases
represent
a
principal
cause
of
mortality
among
the
global
elderly
population,
making
mitigation
vascular
significant
aspiration
for
humanity.
This
article
explores
intersection
nature
health,
focusing
on
role
natural
plant,
pepper,
bioactive
compound,
capsaicin,
in
combating
aging.
By
examining
molecular
cellular
mechanisms
as
well
phenotypic
alterations
blood
vessels,
we
offer
comprehensive
review
effects
capsaicin
receptor,
transient
receptor
potential
vanilloid
1
(TRPV1),
within
We
propose
that
may
serve
medication
with
to
slow
progress
could
constitute
new
strategy
treat
related
disease.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(48), P. 55392 - 55408
Published: Nov. 21, 2023
Diabetic
chronic
wounds
remain
a
major
clinical
challenge
with
long-term
inflammatory
responses
and
extreme
oxidative
damage.
Hence,
pH-responsive
injectable
multifunctional
hydrogel
[Gel/CUR-FCHO/Mg
(GCM)
micromotors]
via
Schiff
base
reaction
between
gelatin
benzaldehyde-grafted
Pluronic
F127
drug-loaded
micelles
(FCHO)
was
fabricated
for
the
first
time.
Dynamic
linkage
endowed
GCM
ability
to
be
self-healing,
injectable,
on-demand
drug
delivery
at
wound
site.
Curcumin
(CUR),
hydrophobic
antioxidative,
anti-inflammatory,
antibacterial
activities,
encapsulated
into
matrix
by
micellization
(CUR-FCHO
micelles).
Simultaneously,
magnesium-based
micromotors
(Mg
micromotors)
were
physically
entrapped
system
providing
active
hydrogen
(H2)
scavenge
reactive
oxygen
species
alleviate
responses.
As
result,
micromotor
displayed
an
inherent
property,
extraordinary
antioxidative
performance,
remarkable
biocompatibility.
In
diabetic
mouse
full-thickness
cutaneous
defect
wound,
could
remodel
microenvironment
stimulate
vascularization
collagen
deposition,
thereby
facilitating
closure
enhancing
tissue
regeneration,
which
offered
promising
therapeutic
option
management.
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Vascular
aging
and
its
associated
diseases
represent
a
principal
cause
of
mortality
among
the
global
elderly
population,
making
mitigation
vascular
significant
aspiration
for
humanity.
This
article
explores
intersection
nature
health,
focusing
on
role
natural
plant,
pepper,
bioactive
compound,
capsaicin,
in
combating
aging.
By
examining
molecular
cellular
mechanisms
as
well
phenotypic
alterations
blood
vessels,
we
offer
comprehensive
review
effects
capsaicin
receptor,
transient
receptor
potential
vanilloid
1
(TRPV1),
within
We
propose
that
may
serve
medication
with
to
slow
progress
could
constitute
new
strategy
treat
related
disease.
