Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis DOI Creative Commons

Madalena B. C. Simões-Abade,

Marlene Patterer,

Alexandra M. Nicaise

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 18, 2024

Multiple sclerosis (MS), a debilitating autoimmune disorder targeting the central nervous system (CNS), is marked by relentless demyelination and inflammation. Clinically, it presents in three distinct forms: relapsing-remitting MS (RRMS), primary progressive (PPMS), secondary (SPMS). While disease-modifying therapies (DMTs) offer some relief to people with RRMS, treatment options for (pMS) remain frustratingly inadequate. This gap highlights an urgent need advanced disease modeling techniques unravel intricate pathology of pMS. Human induced pluripotent stem cell (iPSC) technologies brain organoids are emerging as promising tools both 2D 3D

Language: Английский

hPSCs-derived brain organoids for disease modeling, toxicity testing and drug evaluation DOI
Na Xie, Jinrong Bai,

Ya Hou

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 385, P. 115110 - 115110

Published: Dec. 10, 2024

Language: Английский

Citations

1
Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis DOI Creative Commons

Madalena B. C. Simões-Abade,

Marlene Patterer,

Alexandra M. Nicaise

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 18, 2024

Multiple sclerosis (MS), a debilitating autoimmune disorder targeting the central nervous system (CNS), is marked by relentless demyelination and inflammation. Clinically, it presents in three distinct forms: relapsing-remitting MS (RRMS), primary progressive (PPMS), secondary (SPMS). While disease-modifying therapies (DMTs) offer some relief to people with RRMS, treatment options for (pMS) remain frustratingly inadequate. This gap highlights an urgent need advanced disease modeling techniques unravel intricate pathology of pMS. Human induced pluripotent stem cell (iPSC) technologies brain organoids are emerging as promising tools both 2D 3D

Language: Английский

Citations

0