Photothermal therapy combined with a STING agonist induces pyroptosis, and gasdermin D could be a new biomarker for guiding the treatment of pancreatic cancer DOI Creative Commons
Yanyan Hu,

Erpeng Qi,

C. Chris Yun

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Although photothermal therapy (PTT) can induce antitumour immunity, the mechanisms underlying its effects in pancreatic cancer (PC) require further exploration. In this study, mechanism of action PTT and connection to pyroptosis as well therapeutic potential alone combination with STING agonists, were investigated. addition, a biomarker PC was found stratify patients who are suitable for PTT. We explored whether vitro evaluated efficacy immunity-inducing ability combined agonist (c-di-GMP) immune adjuvant vivo PC. also gasdermin D (GSDMD) expression tumour tissues investigated drug sensitivity patient-derived organoids (PDOs) differential GSDMD expression. Our study demonstrated that local induces via caspase-1/GSDMD pathway elicits immunity. exhibits better than while limiting distant metastasis, enhances response by promoting dendritic cell maturation, increasing frequency infiltrating T cells, converting macrophages from M2 M1 phenotype. we is highly expressed overexpression might suggest increased resistance chemotherapy benefits therapy. confirmed PDOs higher less sensitive chemotherapeutic agent (5-Fluorouracil) lower expression, making new identifying may benefit work, c-di-GMP used an treat first time, results provide clues development novel immunotherapies simultaneously suppress primary tumours metastases. has great selection individualized treatment modalities.

Language: Английский

Drug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer DOI Creative Commons
Ke Ding, Hailong Tian,

Lei Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 24, 2024

Abstract Multi-modal combination therapy is regarded as a promising approach to cancer treatment. Combining chemotherapy and phototherapy an essential multi-modal endeavor. Ivermectin (IVM) potent antiparasitic agent identified having potential antitumor properties. However, the fact that it induces protective autophagy while killing tumor cells poses challenge its further application. IR780 iodide (IR780) near-infrared (NIR) dye with outstanding photothermal (PTT) photodynamic (PDT) effects. hydrophobicity, instability, low uptake of limit clinical applications. Here, we have structurally modified hydroxychloroquine, inhibitor, synthesize novel compound H780. H780 IVM can form H780-IVM nanoparticles (H-I NPs) via self-assembly. Using hyaluronic acid (HA) modify H-I NPs, nano-delivery system HA/H780-IVM (HA/H-I was synthesized for chemotherapy-phototherapy colorectal (CRC). Under NIR laser irradiation, HA/H-I NPs effectively overcame limitations exhibited cytotoxicity. In vitro in vivo experiment results showed excellent anti-CRC Therefore, our study provides strategy CRC treatment could enhance chemo-phototherapy by modulating autophagy.

Language: Английский

Citations

4
A free-radical initiator-based carrier-free smart nanobomb for targeted synergistic therapy of hypoxic breast cancer DOI Creative Commons
Liefeng Hu, Guolei Dong, Xiaohong Li

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3098 - 3109

Published: Jan. 1, 2025

Tumor hypoxia still severely limits the antitumor efficiency. Herein, a free-radical initiator-based carrier-free smart nanobomb with oxygen-independent trimodal therapeutic effects for targeted therapy of hypoxic breast tumor at low dose.

Language: Английский

Citations

0
GSH-responsive paclitaxel prodrug used in chemotherapy in combination with photodynamic therapy DOI
Qianqian Qi, Zhanyu Zhang, Dun Wang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108289 - 108289

Published: Feb. 18, 2025

Language: Английский

Citations

0
H2O2 self-supplying nanoparticles for chemodynamic and synergistic photodynamic therapy to augment cGAS/STING activation DOI
Ai-Hong Zhang,

Wei‐Chuang Kong,

Xiaolei Zhang

et al.

Nanoscale, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Triple negative breast cancer (TNBC) characterized by easy metastasis and poor prognosis is one of the most intractable malignancies.

Language: Английский

Citations

0
Photothermal therapy combined with a STING agonist induces pyroptosis, and gasdermin D could be a new biomarker for guiding the treatment of pancreatic cancer DOI Creative Commons
Yanyan Hu,

Erpeng Qi,

C. Chris Yun

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Although photothermal therapy (PTT) can induce antitumour immunity, the mechanisms underlying its effects in pancreatic cancer (PC) require further exploration. In this study, mechanism of action PTT and connection to pyroptosis as well therapeutic potential alone combination with STING agonists, were investigated. addition, a biomarker PC was found stratify patients who are suitable for PTT. We explored whether vitro evaluated efficacy immunity-inducing ability combined agonist (c-di-GMP) immune adjuvant vivo PC. also gasdermin D (GSDMD) expression tumour tissues investigated drug sensitivity patient-derived organoids (PDOs) differential GSDMD expression. Our study demonstrated that local induces via caspase-1/GSDMD pathway elicits immunity. exhibits better than while limiting distant metastasis, enhances response by promoting dendritic cell maturation, increasing frequency infiltrating T cells, converting macrophages from M2 M1 phenotype. we is highly expressed overexpression might suggest increased resistance chemotherapy benefits therapy. confirmed PDOs higher less sensitive chemotherapeutic agent (5-Fluorouracil) lower expression, making new identifying may benefit work, c-di-GMP used an treat first time, results provide clues development novel immunotherapies simultaneously suppress primary tumours metastases. has great selection individualized treatment modalities.

Language: Английский

Citations

0