A Binary siRNA‐Loaded Tetrahedral DNA Nanobox for Synergetic Anti‐Aging Therapy DOI Open Access
Ziqi Yue, Yichen Yang, Lulingxiao Nie

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Extensive accumulation of senescent cells contributes to organismal aging, and slowing down the process cellular senescence may ameliorate age-related pathologies. Targeted inhibition mechanistic target rapamycin complex 1 (mTORC1) is found suppress conversion senescence. The regulatory-associated protein mTOR (Raptor), a key component mTORC1, has been implicated as important in aging process, its druggability deserves be investigated. Due high efficiency convenience drug construction, siRNA shows great potential silencing Raptor expression via RNA interfering therapy. Here, we developed functionalized anti-aging nanoplatform based on tetrahedral DNA nanostructures (TDNs) encapsulating targeting for synergistic therapy, named siR-TDN

Language: Английский

Tetrahedral framework nucleic acids prevent epithelial-mesenchymal transition-mediated diabetic fibrosis by targeting the Wnt/β-catenin signaling pathway DOI

Yujie Zhu,

Ruijianghan Shi, Weitong Lu

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110140 - 110140

Published: June 1, 2024

Language: Английский

Citations

0
A Binary siRNA‐Loaded Tetrahedral DNA Nanobox for Synergetic Anti‐Aging Therapy DOI Open Access
Ziqi Yue, Yichen Yang, Lulingxiao Nie

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Extensive accumulation of senescent cells contributes to organismal aging, and slowing down the process cellular senescence may ameliorate age-related pathologies. Targeted inhibition mechanistic target rapamycin complex 1 (mTORC1) is found suppress conversion senescence. The regulatory-associated protein mTOR (Raptor), a key component mTORC1, has been implicated as important in aging process, its druggability deserves be investigated. Due high efficiency convenience drug construction, siRNA shows great potential silencing Raptor expression via RNA interfering therapy. Here, we developed functionalized anti-aging nanoplatform based on tetrahedral DNA nanostructures (TDNs) encapsulating targeting for synergistic therapy, named siR-TDN

Language: Английский

Citations

0