Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 20, 2025
Salmonella
is
one
of
the
most
common
foodborne
pathogens,
which
can
cause
severe
enteritis
and
intestinal
microbiota
imbalance.
However,
there
are
limited
strategies
currently
available
for
preventing
or
treating
Salmonella-induced
colitis.
Herein,
we
developed
Cu/Mn-co-doped
ZnO
tandem
nanozyme
(ZnO-CM)
with
pH-responsive
multienzyme-mimicking
activities
via
doping
engineering
treatment
Benefiting
from
co-doping
Cu
Mn,
ZnO-CM
nanospheres
exhibit
remarkable
peroxidase-like
activity
in
acidic
condition
superoxide
dismutase-
catalase-like
neutral
environment.
Animal
experiments
show
that
efficiently
inhibit
bacterial
growth,
alleviate
inflammation,
restore
barrier,
resulting
good
antibacterial
anti-inflammatory
effects
on
Mechanistically,
functions
through
inhibiting
continuous
accumulation
ROS,
increasing
levels
tight
junction
proteins
occludin
claudin-1,
decreasing
expression
pro-inflammatory
cytokines
IL-1β
IL-6
intestine.
This
work
not
only
presents
an
effective
paradigm
colitis
therapy,
but
also
provides
new
sights
into
prevention
other
enteritis.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(15), P. 3745 - 3764
Published: Jan. 1, 2024
Hydrogels,
as
an
emerging
biomaterial,
have
found
extensive
use
in
the
healing
of
wounds
due
to
their
distinctive
physicochemical
structure
and
functional
properties.
Moreover,
hydrogels
can
be
made
match
a
range
therapeutic
requirements
for
materials
used
wound
through
specific
modifications.
This
review
provides
step-by-step
explanation
processes
involved
cutaneous
healing,
including
hemostasis,
inflammation,
proliferation,
reconstitution,
along
with
investigation
factors
that
impact
these
processes.
Furthermore,
thorough
analysis
is
conducted
on
various
stages
process
at
which
are
implemented,
anti-infection
measures,
encouraging
regeneration,
scar
reduction,
monitoring.
Next,
latest
progress
multifunctional
methods
achieve
functions
discussed
depth
categorized
elucidation.
Finally,
perspectives
challenges
associated
clinical
applications
discussed.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 20, 2025
Salmonella
is
one
of
the
most
common
foodborne
pathogens,
which
can
cause
severe
enteritis
and
intestinal
microbiota
imbalance.
However,
there
are
limited
strategies
currently
available
for
preventing
or
treating
Salmonella-induced
colitis.
Herein,
we
developed
Cu/Mn-co-doped
ZnO
tandem
nanozyme
(ZnO-CM)
with
pH-responsive
multienzyme-mimicking
activities
via
doping
engineering
treatment
Benefiting
from
co-doping
Cu
Mn,
ZnO-CM
nanospheres
exhibit
remarkable
peroxidase-like
activity
in
acidic
condition
superoxide
dismutase-
catalase-like
neutral
environment.
Animal
experiments
show
that
efficiently
inhibit
bacterial
growth,
alleviate
inflammation,
restore
barrier,
resulting
good
antibacterial
anti-inflammatory
effects
on
Mechanistically,
functions
through
inhibiting
continuous
accumulation
ROS,
increasing
levels
tight
junction
proteins
occludin
claudin-1,
decreasing
expression
pro-inflammatory
cytokines
IL-1β
IL-6
intestine.
This
work
not
only
presents
an
effective
paradigm
colitis
therapy,
but
also
provides
new
sights
into
prevention
other
enteritis.
