Electrical Stimulating Redox Membrane Incorporated with PVA/Gelatin Nanofiber for Diabetic Wound Healing DOI
Jeong‐Uk Kim, Junghyeon Ko, Y. J. Kim

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: July 11, 2024

Abstract Chronic wounds adversely affect the quality of life. Although electrical stimulation has been utilized to treat chronic wounds, there are still limitations practicing it due complicated power system. Herein, an electrostimulating membrane incorporated with electrospun nanofiber (M‐sheet) diabetic is developed. Through screen printing method, various alternate patterns both Zn and AgCl on a polyurethane substrate, generating redox‐mediated fields introduced. The antibacterial ability patterned against E. coli S. aureus confirmed. Furthermore, poly(vinyl alcohol) (PVA)/gelatin fiber into enhance biocompatibility maintain wet condition in wound environment. M‐sheet can improve cell proliferation migration vitro immune regulatory effect by inducing polarization macrophage M2 phenotype. Finally, when applied skin model, displays accelerated healing rate enhances re‐epithelialization, collagen synthesis, angiogenesis. It suggests that simple portable system for spontaneous generation great potential be used practical other tissue engineering applications.

Language: Английский

Electrospinning of nanofibres DOI
Dongxiao Ji,

Yagai Lin,

Xinyue Guo

et al.

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: Jan. 4, 2024

Language: Английский

Citations

204
All‐in‐One Self‐Powered Microneedle Device for Accelerating Infected Diabetic Wound Repair DOI
Weikun Li, Zonghao Liu, Xin Tan

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(13)

Published: Feb. 7, 2024

Abstract Diabetic wound healing remains a significant clinical challenge due to the complex microenvironment and attenuated endogenous electric field. Herein, novel all‐in‐one self‐powered microneedle device (termed TZ@mMN‐TENG) is developed by combining multifunctional carried tannin@ZnO microparticles (TZ@mMN) with triboelectric nanogenerator (TENG). In addition delivery of tannin Zn 2+ , TZ@mMN also effectively conducts electrical stimulation (ES) infected diabetic wounds. As device, TENG can convert biomechanical motion into exogenous ES accelerate healing. vitro experiment demonstrated that shows excellent conductive, high antioxidant ability, effective antibacterial properties against both Staphylococcus aureus Escherichia coli (>99% rates). Besides, TZ@mMN‐TENG promote cell proliferation migration. rat full‐thickness skin model eliminate bacteria, epidermal growth (regenerative epidermis: ≈303.3 ± 19.1 µm), enhance collagen deposition, inhibit inflammation (lower TNF‐α IL‐6 expression), angiogenesis (higher CD31 VEGF expression) repair. Overall, provides promising strategy for application in

Language: Английский

Citations

23
Bioelectronics for electrical stimulation: materials, devices and biomedical applications DOI
Ya Huang, Kuanming Yao, Qiang Zhang

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712

Published: Jan. 1, 2024

Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.

Language: Английский

Citations

22
Wearable Magnetoelectric Stimulation for Chronic Wound Healing by Electrospun CoFe2O4@CTAB/PVDF Dressings DOI
Qi Ke, Xinyi Zhang, Yuan Yang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(8), P. 9839 - 9853

Published: Feb. 19, 2024

Magnetoelectric stimulation is a promising therapy for various disorders due to its high efficacy and safety. To explore potential in chronic skin wound treatment, we developed magnetoelectric dressing, CFO@CTAB/PVDF (CCP), by electrospinning cetyltrimethylammonium bromide-modified CoFe2O4 (CFO) particles with polyvinylidene fluoride. Cetyltrimethylammonium bromide (CTAB) serves as dispersion surfactant CFO, quaternary ammonium cations imparting antibacterial hydrophilic properties the dressing. Electrospinning polarizes fluoride (PVDF) molecules forms fibrous membrane flexibility breathability. With wearable electromagnetic induction device, dynamic magnetic field established induce magnetostrictive deformation of CFO nanoparticles. Consequently, piezoelectric generated on surface PVDF nanofibers enhance endogenous electrical wound, achieving cascade coupling electric–magnetic–mechanical–electric effects. Bacteria cell cultures show that 2% CTAB effectively balances property fibroblast activity. Under stimulation, CCP dressing demonstrates significant upregulation TGF-β, FGF, VEGF, promoting L929 adhesion proliferation. Moreover, it facilitates healing diabetic rat wounds infected Staphylococcus aureus within 2 weeks. Histological molecular biology evaluations confirm anti-inflammatory effect accelerated formation collagen vessel stimulation. This work provides insights into application wounds.

Language: Английский

Citations

21
Biopolymer and Biomimetic Techniques for Triboelectric Nanogenerators (TENGs) DOI
Zhaoqi Liu, Xiangyu Chen, Zhong Lin Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Triboelectric nanogenerators (TENGs) play a crucial role in attaining sustainable energy for various wearable devices. Polymer materials are essential components of TENGs. Biopolymers suitable TENGs because their degradability, natural sourcing, and cost-effectiveness. Herein, the latest progress commonly used biopolymers well-designed biomimetic techniques TENG is summarized. The applications rubber, polysaccharides, protein-based biopolymers, other common synthetic technology summarized detail. Each biopolymer discussed based on its electrification capability, polarity variations, specific functionalities as active functional layers Important strategies related also to guide structural design TENG. In future, study triboelectric may focus exploring alternative candidates, enhancing charge density, expanding functionality. Various possible biopolymer-based proposed this review. By applying methods devices, fields healthcare, environmental monitoring, wearable/implantable electronics can be further promoted.

Language: Английский

Citations

19
Multiple-dynamic-bond crosslinked ion-elastomers achieve a combination of photothermal antibacterial and self-powered electrical stimulation for infected wound healing DOI

Kangbo Chen,

Xiaolin Li,

Peipei Su

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: 121, P. 109260 - 109260

Published: Jan. 5, 2024

Language: Английский

Citations

17
Asymmetric wettability fibrous membranes: Preparation and biologic applications DOI
Mingyu Zhang, Lei Chu, Jia−Hua Chen

et al.

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 269, P. 111095 - 111095

Published: Nov. 18, 2023

Language: Английский

Citations

33
Sequential Anti-Infection and Proangiogenesis of DMOG@ZIF-8/Gelatin-PCL Electrospinning Dressing for Chronic Wound Healing DOI

Lei Yin,

Qiwen Tang,

Qi Ke

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(42), P. 48903 - 48912

Published: Oct. 16, 2023

Bacterial infection and insufficient neovascularization are two major obstacles to the healing of chronic wounds. Here, we present an antibacterial proangiogenic dressing by encapsulating dimethyloxalylglycine (DMOG) in zeolitic imidazolate framework-8 (ZIF-8) electrospinning it with gelatin-polycaprolactone (Gel-PCL). As Gel-PCL nanofibers degrade, ZIF-8 nanoparticles decompose, sequentially releasing bactericidal zinc ions angiogenic DMOG molecules. This cascade process matches wound-healing stages, ensuring suitable bioavailability effective duration active components while minimizing their side effects. In vitro, released from (2.5% DMOG@ZIF-8) can eliminate over 90% Escherichia coli Staphylococcus aureus without compromising fibroblast cell proliferation adhesion. vivo, heal skin wounds aureus-infected diabetic rats within 2 weeks, facilitated molecules discharged (loading rate 21.3%). Immunohistochemical analysis confirmed regulated expression factors work provides new insights into design multifunctional dressings for treatment

Language: Английский

Citations

27
Permeable Bioelectronics toward Biointegrated Systems DOI
Sunghoon Lee, Xiaoping Liang, Joo Sung Kim

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(10), P. 6543 - 6591

Published: May 10, 2024

Bioelectronics integrates electronics with biological organs, sustaining the natural functions of organs. Organs dynamically interact external environment, managing internal equilibrium and responding to stimuli. These interactions are crucial for maintaining homeostasis. Additionally, organs possess a soft stretchable nature; encountering objects differing properties can disrupt their function. Therefore, when electronic devices come into contact objects, permeability these devices, enabling substance exchanges mechanical compliance inherent functionality This review discusses recent advancements in permeable bioelectronics, emphasizing materials, structures, wide range applications. The also addresses current challenges potential solutions, providing insights integration

Language: Английский

Citations

12
Rationally Improved Surface Charge Density of Triboelectric Nanogenerator with TiO2‐MXene/Polystyrene Nanofiber Charge Trapping Layer for Biomechanical Sensing and Wound Healing Application DOI Creative Commons
Manikandan Venkatesan, Jayashree Chandrasekar, Yung‐Chi Hsu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Abstract Triboelectric nanogenerators (TENGs) have become reliable green energy harvesters by converting biomechanical motions into electricity. However, the inevitable charge leakage and poor electric field (EF) of conventional TENG result in inferior tribo‐charge density on active layer. In this paper, TiO 2 ‐MXene incorporated polystyrene (PS) nanofiber membrane (PTMx NFM) trapping interlayer is introduced single electrode mode (S‐TENG) to prevent electron loss at interface. Surprisingly, charge‐trapping mechanism augments surface output performance TENGs. Polyvinylidene difluoride (PVDF) mixed polyurethane (PU) NFM used as tribo‐active layer, which improves crystallinity mechanical property PVDF delamination during long cycle tests. Herein, effect double‐layer capacitive model explained experimentally theoretically. With optimization PTMx thickness, S‐TENG exhibits a maximum open‐circuit voltage (280 V), short‐circuit current (20 µA) transfer (120 nC), power (25.2 µW cm −2 ). Then, utilized electrical appliances. addition, influence AC/DC EF simulation wound healing management (vitro L929 cell migration, vivo tissue regeneration) also investigated changing polarity trans‐epithelial potential (TEP) distribution wounded area.

Language: Английский

Citations

11