Novel Injectable, Self-Healing, Long-Effective Bacteriostatic, and Healed-Promoting Hydrogel Wound Dressing and Controlled Drug Delivery Mechanisms

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(2), P. 2140 - 2153

Published: Jan. 5, 2024

Multivalent ion cross-linking has been used to form hydrogels between sodium alginate (SA) and hyaluronic acid (HA) in previous studies. However, more stable robust covalent is rarely reported. Herein, we present a facile approach fabricate SA HA hydrogel for wound dressings with injectable, good biocompatibility, high ductility. was first reacted ethylenediamine graft an amino group. Then, it cross-linked oxidized dialdehyde networks. The dressing can effectively promote cell migration healing. To increase the antibacterial property of dressing, successfully loaded tetracycline hydrochloride into as model drug. drug be released slowly alkaline environment chronic wounds, releases drugs again acidic healing, achieving long-term effect. In addition, one-dimensional partial differential equations based on Fickian diffusion time-varying coefficients thicknesses were entire complex release process predict release.

Language: Английский

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Advances in the construction and application of konjac glucomannan-based delivery systems

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129940 - 129940

Published: Feb. 5, 2024

Language: Английский

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Preparation of a biodegradable packaging film by konjac glucomannan/sodium alginate reinforced with nitrogen-doped carbon quantum dots from crayfish shell for crayfish meat preservation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 139596 - 139596

Published: Jan. 1, 2025

Language: Английский

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Konjac glucomannan-based composite materials: Construction, biomedical applications, and prospects

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 344, P. 122503 - 122503

Published: July 19, 2024

Language: Английский

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Metal-organic framework-based advanced therapeutic tools for antimicrobial applications

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 175, P. 27 - 54

Published: Dec. 17, 2023

The escalating concern over conventional antibiotic resistance has emphasized the urgency in developing innovative antimicrobial agents. In recent times, metal−organic frameworks (MOFs) have garnered significant attention within realm of research due to their multifaceted attributes, including sustained release intrinsic or exogenous components, chemodynamically catalyzed generation reactive oxygen species (ROS), and formation photogenerated ROS. This comprehensive review provides a thorough overview synthetic approaches employed production MOF-based materials, elucidating underlying mechanisms depth. focal point lies advancements across various modalities, encompassing component system, extraneous auto-catalytical energy conversion system. Additionally, progress materials addressing wound infections, osteomyelitis, periodontitis is meticulously elucidated, culminating summary challenges potential opportunities inherent applications for materials. Growing concerns about need alternative solutions. Metal-organic gained diverse attributes like components release, catalytic covers MOF synthesis mechanisms. It explores auto-catalysis, systems. paper also discusses materials' periodontitis, along with existing opportunities. Given lack related reviews, our findings hold promise future antibacterial research, making it relevant your journal's readership.

Language: Английский

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Bioinspired Glycopeptide Hydrogel Reestablishing Bone Homeostasis through Mediating Osteoclasts and Osteogenesis in Periodontitis Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29507 - 29521

Published: Oct. 14, 2024

Irreversible alveolar bone resorption is one of the important clinical manifestations periodontitis, which initiated by a plaque biofilm and exacerbated imbalance osteoclast activity osteogenesis, affecting patient's masticatory function resulting in high recurrence rate periodontitis. Herein, to reestablish homeostasis minocycline hydrochloride (MH)-loaded glycopeptide hydrogel (MH/GRWgel) fabricated mediate absorption through sequential antibacterial RANKL-blocking activities. GRWgel shows an ECM-like fibrous porous microstructure serving as scaffold for cell proliferation differentiation holds merits including injectability, self-healing properties, good biocompatibility. After injection situ, MH released rapidly from early stage, demonstrating potent antimicrobial effect combat deep periodontal pocket. Moreover, MH/GRWgel exhibits specific binding efficiency with RANKL suppress maturation shielding RANKL/RANK interaction enhancing osteogenic differentiation, thereby synergistically regulating homeostasis. In rat periodontitis model, significantly curtails progression activity, inhibition resorption, promotion regeneration, superior treatment commercial gel. These findings suggest that superiority provides promising therapeutic strategy

Language: Английский

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Metal-organic frameworks integrated into carbohydrate polymers as promising platforms for tissue engineering

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156847 - 156847

Published: Oct. 1, 2024

Language: Английский

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NF-κB-Signaling-Targeted Immunomodulatory Nanoparticle with Photothermal and Quorum-Sensing Inhibition Effects for Efficient Healing of Biofilm-Infected Wounds

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 25757 - 25772

Published: May 13, 2024

The development of therapeutics with high antimicrobial activity and immunomodulatory effects is urgently needed for the treatment infected wounds due to increasing danger posed by recalcitrant-infected wounds. In this study, we developed light-controlled antibacterial, photothermal, biomimetic N/hPDA@M nanoparticles (NPs). This nanoplatform was loading flavonoid naringenin onto hollow mesoporous polydopamine NPs in a π-π-stacked configuration encasing them macrophage membranes. First, our efficiently neutralized inflammatory factors present within wound microenvironment integration Afterward, effectively dismantled bacterial biofilms through combination photothermal properties PDA quorum sensing inhibitory naringenin. It worth noting that near-infrared-enhanced release exhibited specificity toward NF-κB-signaling pathway, mitigating response. innovative design not only conferred remarkable antibacterial upon but also endowed capacity modulate responses, curbing excessive inflammation steering polarization M2 phenotype. As result, multifaceted approach significantly contributes expediting healing process skin

Language: Английский

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Recent Progress in Multifunctional Stimuli-Responsive Combinational Drug Delivery Systems for the Treatment of Biofilm-Forming Bacterial Infections

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 976 - 976

Published: July 24, 2024

Drug-resistant infectious diseases pose a substantial challenge and threat to medical regimens. While adaptive laboratory evolution provides foresight for encountering such situations, it has inherent limitations. Novel drug delivery systems (DDSs) have garnered attention overcoming these hurdles. Multi-stimuli responsive DDSs are particularly effective due their reduced background leakage targeted specific host sites pathogen elimination. Bacterial infections create an acidic state in the microenvironment (pH: 5.0-5.5), which differs from normal physiological conditions 7.4). Infected areas characterized by overexpression of hyaluronidase, gelatinase, phospholipase, other virulence factors. Consequently, several stimuli-responsive been developed target bacterial pathogens. Additionally, biofilms, structured communities bacteria encased self-produced polymeric matrix, significant conferring resistance conventional antimicrobial treatments. Recent advancements nano-drug (nDDSs) show promise enhancing efficacy improving absorption targeting within biofilm matrix. nDDSs can deliver antimicrobials directly biofilm, facilitating more eradication resilient communities. Herein, this review examines challenges DDS development, focusing on antibacterial activity eradicating biofilms without adverse effects. Furthermore, advances immune system modulation photothermal therapy discussed as future directions treatment diseases.

Language: Английский

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Antioxidative, Anti-Inflammatory, Antibacterial, Photo-Cross-Linkable Hydrogel of Gallic Acid–Chitosan Methacrylate: Synthesis, In Vitro, and In Vivo Assessments

Biomacromolecules, Journal Year: 2024, Volume and Issue: 25(7), P. 4358 - 4373

Published: June 26, 2024

Chitosan (CS)-based photo-cross-linkable hydrogels have gained increasing attention in biomedical applications. In this study, we grafted CS with gallic acid (GA) by carbodiimide chemistry to prepare the GA-CS conjugate, which was subsequently modified methacrylic anhydride (MA) modification obtain methacrylated conjugate (GA-CS-MA). Our results demonstrated that GA-CS-MA hydrogel not only exhibited improved physicochemical properties but also showed antibacterial, antioxidative, and anti-inflammatory capacity. It moderate antibacterial activity especially a more powerful inhibitory effect against Gram-positive bacteria. modulated macrophage polarization, downregulated pro-inflammatory gene expression, upregulated significantly reduced reactive oxygen species (ROS) nitric oxide (NO) production under lipopolysaccharide (LPS) stimulation. Subcutaneously implanted induced lower inflammatory responses, as evidenced less cell infiltration, thinner fibrous capsule, predominately promoted M2 polarization. This study provides feasible strategy CS-based for

Language: Английский

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