Tumor Microenvironment-Responsive Drug Delivery Based on Polymeric Micelles for Precision Cancer Therapy: Strategies and Prospects

Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 417 - 417

Published: Feb. 11, 2024

In clinical practice, drug therapy for cancer is still limited by its inefficiency and high toxicity. For precision therapy, various delivery systems, including polymeric micelles self-assembled from amphiphilic materials, have been developed to achieve tumor-targeting delivery. Considering the characteristics of pathophysiological environment at target site, design, synthesis, or modification environmentally responsive materials has become a crucial strategy drug-targeted comparison normal physiological environment, tumors possess unique microenvironment, characterized low pH, reactive oxygen species concentration, hypoxia, distinct enzyme providing stimuli design micelles. Polymeric with tumor microenvironment (TME)-responsive shown significant improvement in treatment. This review mainly outlines most promising strategies available exploiting construct internal stimulus-responsive that enhanced antitumor efficacy. addition, prospects TME-responsive gene immunotherapy, popular current treatments, are also discussed. via will be an efficient robust approach developing therapies future.

Language: Английский

---

Multi‐responsive co‐assembled polyurethane nanomicelles as anticancer drug delivery carriers

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: 141(34)

Published: June 6, 2024

Abstract In order to obtain a kind of anticancer drug delivery carriers with good stability in blood circulation, high cellular uptake, and controlled release ability, folate‐modified polyurethane disulfide bonds amino groups (FPUSN) carboxyl (PUC) were respectively synthesized. FPUSN PUC could co‐assemble water form nanomicelles (FPUSN/PUC) via electrostatic interaction. When the mass ratio was 12, FPUSN/PUC‐12 micelles had obvious negative‐to‐positive charge‐reversal property decreasing pH from 7.4 5.0. Doxorubicin‐loaded (FPUSN/PUC‐12@DOX) negative charges showed excellent under simulated normal physiological condition. However, happened at 6.5 positive increased decrease. glutathione concentration 10 mM, structure FPUSN/PUC‐12@DOX broken. So exhibited significant acid/reduction‐sensitive properties then DOX be rapidly released tumor intracellular environment. Cellular experimental results demonstrated that enhance uptake acid condition better anti‐proliferation effect against HGC‐27 cells than owing multi‐responsive synergistic effects. Therefore, FPUSN/PUC will have great application potential as for enhancing efficacy.

Language: Английский

---

Advances, limitations and perspectives in the use of celecoxib-loaded nanocarriers in therapeutics of cancer

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 6, 2024

Cancer is highlighted as a major global health challenge in the XXI century. The cyclooxygenase-2 (COX-2) enzyme rises widespread tumor progression marker. Celecoxib (CXB) selective COX-2 inhibitor used adjuvant cancer therapy, but high concentrations are required humans. In this sense, development of nanocarriers has been proposed once they can improve biopharmaceutical, pharmacokinetic and pharmacological properties drugs. context, article reviews progress CXB-loaded over past decade their prospects. Recent advances field demonstrate use complex formulations increasing importance vivo studies. types that have developed heterogeneous based on polymers lipids together or separately. It was found work carried out using established techniques raw materials, such poly (lactic-co-glicolic acid), cholesterol, phospholipids poly(ethyleneglycol). main improvements achieved cell surface ligands, simultaneous delivery different synergistic agents, presence materials provide imaging other advanced features. combination CXB with anti-inflammatory drugs and/or apoptosis inducers appears to hold effective promise. greatest advance date from clinical perspective ability enhance cytotoxic effects chemotherapeutic agents.

Language: Английский

---

Multi-drug sequential release systems: Construction and application for synergistic tumor treatment

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 125156 - 125156

Published: Dec. 1, 2024

Language: Английский

---