Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review DOI

Parinaz Nezhad‐Mokhtari,

Reza Rahbarghazi‬, Hamed Hamishehkar

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Electrospun organic/inorganic hybrid nanofibers for accelerating wound healing: a review DOI
Sai Yan,

Yuqi Qian,

Marjan Haghayegh

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(13), P. 3171 - 3190

Published: Jan. 1, 2024

This review summarizes fabrication strategies and manifold applications of electrospun organic/inorganic hybrid nanofibers in promoting the wound healing process.

Language: Английский

Citations

35
In situ growth of ZIF-8 nanoparticles on pure chitosan nanofibrous membranes for efficient antimicrobial wound dressings DOI
Xiaotong Zhang, Yanxin Wang, Xing Wei

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139921 - 139921

Published: Jan. 14, 2025

Language: Английский

Citations

1
Preparation of pH-sensitive porous polylactic acid-based medical dressing with self-pumping function DOI
Zijian Zhang, Jianyong Li, Yi Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131563 - 131563

Published: April 16, 2024

Language: Английский

Citations

4
Enhanced Osteogenic Differentiation of hMSCs Using BMP@ZIF-8-Loaded GelMA Nanocomposite Hydrogels with Controlled BMP-2 Release DOI Creative Commons
Weihao Yuan, Luiza de Almeida Queiroz Ferreira,

Ronit Khade

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Hydrogels are highly versatile materials with immense potential for tissue engineering and regenerative medicine owing to their biocompatibility, tunable mechanical properties, ability mimic the natural extracellular matrix. Their 3D porous structure allows encapsulation delivery of bioactive molecules, making them ideal candidates drug systems. In repair, particularly bone regeneration, hydrogels can serve as carriers that release therapeutic agents in a controlled manner, thus enhancing healing process. Zeolitic Imidazolate Framework-8 (ZIF-8) nanoparticles recombinant human Bone Morphogenetic Protein (rhBMP-2) molecules were incorporated solely (ZIF@GelMA) or association (BMP@ZIF@GelMA) into gelatin modified by methacryloyl hydrogel (GelMA) investigate its physical osteogenic properties. characterized Scanning Electron Microscopy rheological tests. We analyzed degradation BSA profile BMP@ZIF@GelMA samples throughout 0, 1, 3, 7, 14, 28 days. Cell adhesion formation markers hydrogel-encapsulated dental pulp cells using immunocytochemistry molecular analysis. ZIF@GelMA exhibited viscoelastic increased storage modulus when rhBMP2 was present. BSA@ZIF@GelMA showed balanced rate BSA. The upregulated expression cell genes, BMP-2 introduced, levels remarkably elevated. presents several favorable factors promote cellular encouraging further prospects advanced applications repair.

Language: Английский

Citations

0
Tri‐Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full‐Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies DOI Creative Commons
Ayşe Günyaktı, Ayşe Karakeçili, Berna Topuz

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Chronic infected diabetic wounds are complex and often lead to severe clinical outcomes such as sepsis, gangrene, amputation. To address these challenges, herein we developed a novel tri‐layered scaffold provide multi‐functional therapeutic support. The bottom poly (lactic‐co‐glycolic acid) (PLGA) fibrous layer contains doxycycline loaded CuBDC nanosheets for rapid antibacterial action. porous PLGA/gelatin middle offers mechanical support γ‐tocotrienol ZIF‐8 nanocrystals mitigates oxidative stress in the wound. PLGA top sealing delivers insulin Transforming growth factor beta (TGF‐β1) from Zeolitic Imidazolate Framework‐8 (ZIF‐8) promote epithelialization modulate inflammation. Comprehensive vitro vivo evaluations demonstrated that effectively filled deep wounds, reduced bacterial load, controlled inflammation, accelerated tissue regeneration. Histopathological analyses showed enhanced partial granulation remodeling. Biochemical assays indicated an increase glutathione peroxidase (GPx) activity reduction lipid peroxidation. Gene expression analysis revealed decreased levels of pro‐inflammatory TNF‐α increased anti‐inflammatory IL‐10, facilitating transition proliferative phase. This multi‐layered composite scaffold, with its antimicrobial, antioxidant, activities, release capabilities, presents promising solution healing process deep, wounds.

Language: Английский

Citations

0
Electrospinning and electrospun nanofibers: From academic research to industrial production DOI
Ce Wang, Wei Wang,

Hongxu Qi

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101494 - 101494

Published: April 1, 2025

Language: Английский

Citations

0
Bioactive hydrogel (ZIF-8@CMC-PVA-SA) as dressing materials for wound healing applications DOI
Muhammad Umar Aslam Khan, Mohamed Hashem, Hassan Fouad

et al.

Materials Today Communications, Journal Year: 2024, Volume and Issue: 42, P. 111282 - 111282

Published: Dec. 11, 2024

Language: Английский

Citations

3
Innovative Nanocomposite Scaffolds Containing ZIF-8 Nanoparticles for Improving Wound Healing: A Review DOI

Parinaz Nezhad‐Mokhtari,

Reza Rahbarghazi‬, Hamed Hamishehkar

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Language: Английский

Citations

2