ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(45), P. 62064 - 62081
Published: Oct. 31, 2024
Photosensitizing
assemblies
based
on
twisted
intramolecular
charge
transfer
(TICT)
active
donor–acceptor–donor
(D-A-D)
system
BrTPA-Qx
having
bromine
atoms
at
the
periphery
have
been
developed.
Through
strategic
incorporation
of
para-position
to
nitrogen–carbon
bonds
phenyl
rings
periphery,
halogen–halogen
interactions
are
induced
in
nanoassemblies
H2O:DMSO
(99:1)
solution.
Hence,
anti-heavy
atom
effect
is
induced,
and
limitations
TICT
(dark
excited
state)
heavy
(triplet
deactivation
via
radiative
decay)
could
be
overcome.
Because
effect,
supramolecular
demonstrate
high
efficiency
promoting
activation
aerial
oxygen
electron
energy
pathways
aqueous
media.
The
significant
influence
stabilized
state
anti-heavy-atom
controlling
ROS
generation
was
validated
through
in-depth
solvent-dependent
photophysical
studies
investigations
structure–activity
relationship
several
model
compounds.
notable
photosensitizing
activity
manifested
their
ability
efficiently
catalyze
oxidative
coupling
benzylamine
(via
type
I
II
mechanisms),
Knoevenagel
condensation
aromatic
aldehydes
(type
II),
hydroxylation
arylboronic
acids
I)
under
mild
conditions.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Abstract
Organic
semiconducting
small
molecules
that
simultaneously
possess
NIR‐IIb
(1500–1700
nm)
fluorescence
imaging
(FLI),
hypoxia‐tolerant
photodynamic
therapy
(PDT)
as
well
photothermal
(PTT)
abilities
activated
by
a
single
NIR‐II
(1000‐1700
light
can
achieve
high‐performance
deep‐tissue
phototheranostics,
but
have
not
gain
much
attention.
Herein,
novel
organic
molecule
(DTT)
with
an
absorption
maximum
at
844
nm
and
emission
944
in
its
monomer
state
is
synthesized
through
delicate
molecular
design.
Surprisingly,
the
spectrum
of
DTT
extend
into
region.
Subsequently,
phototheranostic
nanoparticles
(DTT
NPs)
dramatically
red‐shifted
absorption/emission
peak
(1029/1128
are
skillfully
developed
based
on
J
‐aggregation
strategy,
which
show
greatly
high
molar
absorptivity
Upon
1064
excitation,
resolution
FLI
be
achieved
whole‐body
vessels,
cerebral
vasculatures,
tumors
living
mice
treated
NPs.
Moreover,
NPs
also
produce
type‐I
reactive
oxygen
species
hyperthermia
under
laser
irradiation
for
oxygen‐less‐dependent
PDT
PTT
combination
therapy,
eventually
achieving
efficient
antitumor
effects.
This
work
provides
facile
strategy
designing
high‐efficiency
phototheranostics.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Abstract
Photosensitizers
with
near‐infrared
(NIR)
excitation,
especially
above
800
nm
which
is
highly
desired
for
phototherapy,
remain
rare
due
to
the
fast
nonradiative
relaxation
process
induced
by
exciton‐vibration
coupling.
Here,
a
diketopyrrolopyrrole‐derived
photosensitizer
(DTPA‐S)
developed
via
thionation
of
carbonyl
groups
within
diketopyrrolopyrrole
skeleton,
results
in
large
bathochromic
shift
81
nm,
endowing
strong
NIR
absorption
at
712
nm.
DTPA‐S
then
introduced
functional
biomolecule
(N
3
‐PEG
2000
‐RGD)
click
reaction
construction
integrin
αvβ3
receptor‐targeted
nano‐micelles
(NanoDTPA‐S/RGD),
endows
further
superlarge
redshift
138
thus
extending
maxima
≈850
Remarkably,
thiocarbonyl
substitution
increases
nonbonding
characters
frontier
molecular
orbitals,
can
effectively
suppress
vibrational
reducing
reorganization
energy,
enabling
efficient
reactive
oxygen
species
(ROS)
generation
under
880
excitation.
Screened
vitro
and
vivo
assays,
NanoDTPA‐S/RGD
high
water
solubility,
excellent
tumor‐targeting
ability,
photodynamic/photothermal
therapy
synergistic
effect
exhibits
satisfactory
phototherapeutic
performance.
Overall,
this
study
demonstrates
new
design
NIR‐triggered
facile
installation
biomolecules
potential
clinical
applications.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Fluorescence
imaging
in
the
second
near-infrared
region
(NIR-II,
1000-1700
nm)
has
garnered
considerable
attention
for
displaying
biological
information
of
deep
tissues.
However,
lack
biocompatible
contrast
agents
with
bright
NIR-II
emission
hampered
precise
clinical
application
tissue
imaging.
Here,
a
lipophilic
enhancement
strategy
employing
donor-acceptor-donor
(D-A-D)
molecules,
introducing
long
alkoxy
chains
and
quaternary
ammonium
salts
development
highly
water-soluble
fluorophores
(BBTD-2C-N),
is
described.
Notably,
liposome-encapsulated
BBTD-2C-N
nanoparticles
(B-2C-N/DMPC)
aqueous
solution
exhibit
1.8-fold
increase
fluorescence
brightness
compared
to
free
methanol.
Avoidance
aggregation-caused
quenching
effect
enhanced
are
attributed
significantly
attenuated
π-π
stacking
interactions
maintained
monodisperses
hydrophobic
liposome
shell.
Moreover,
demonstrates
superior
performance
visualizing
lipid
droplet-rich
HeLa
cells
vitro,
as
well
monitoring
adipose
fatty
liver
vivo.
This
study
reveals
new
avenue
vivo
Polymers,
Journal Year:
2024,
Volume and Issue:
16(23), P. 3365 - 3365
Published: Nov. 29, 2024
The
market
demand
for
black
polyimide
(BPI)
has
grown
hugely
in
the
field
of
flexible
copper-clad
laminates
(FCCLs)
as
a
replacement
transparent
yellow
polyimide.
3,6-bis(thiophen-2-yl)diketopyrrolopyrroles
(TDPP)
derivative
is
recognized
its
high
molar
extinction
coefficient.
In
this
research,
we
have
synthesized
diamine
monomer
named
3,6-bis[5-(4-amino-3-fluorophenyl)thiophen-2-yl]-2,5-bis(2-ethylhexyl)pyrrolo[4,3-c]pyrrole-1,4-dione
(DPPTENFPDA),
featuring
TDPP
unit
attached
by
fluorinated
benzene
rings.
subsequent
reaction
DPPTENFPDA
with
pyromellitic
dianhydride
(PMDA)
yielded
an
inherent
BPI
(DPPTENFPPI).
By
introducing
chromophores
derived
from
TDPP,
light
absorption
spectrum
DPPTENFPPI
was
broadened
and
red-shifted,
thereby
achieving
full
within
visible
producing
highly
color
that
cut-off
wavelength
(
