Morin hydrate reduces survival and fertility, delays development and weakens lipid reserves in Aedes aegypti DOI Creative Commons
Luan Valim dos Santos, Elaine Rodrigues Miranda Nery da Silva, Matheus Silva Caiado

et al.

Medical and Veterinary Entomology, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract The Aedes aegypti mosquito is generally associated with arboviruses that cause yellow fever, dengue, zika and chikungunya. most efficient way to control their populations through application in breeding sites of highly toxic insecticides can also impact non‐target organisms generate resistant populations. Therefore, the use compounds desirable. Morin hydrate has broad pharmacological applications based on its antioxidant potential, addition not having negative effects mammals. objective present study was investigate morin A. survival, pupation rate, egg laying, triacylglycerol reserves expression proteins related lipid metabolism 24 h after exposure larvae. For this, rearing media containing larvae different concentrations were formulated evaluate lethal concentration. Calculation expected showed LC 25 52.692 μM, 40 111.121 50 174.775 75 575.083 μM 90 1685.936 μM. Twenty‐four hours treatment hydrate, surviving transferred morin‐free water food, rate fertility evaluated. We observed an increase concentration induced a dose‐dependent reduction doubled time survivors reduced number eggs laid by treated females during larval stage approximately 30% at exceeding 100 From (TAG) stock evaluated, evaluating involved metabolism. Larvae TAG 17%, while 175 there more than 33% stocks, 500 61%. Furthermore, lipolytic TAGL1 HSL upregulated, lipogenic FAS1, DGAT1 GPAT1 downregulated. Insulin‐like receptors downregulated, unlike AKHr, which upregulated. These data demonstrate reduces survival affecting did exhibit toxicity toward organisms, demonstrating interesting potential for

Language: Английский

A Single H2S-Releasing Nanozyme for Comprehensive Diabetic Wound Healing through Multistep Intervention DOI
Ying Yin, Wentai Guo,

Q Y Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive environments, such as hyperglycemia, bacterial infection, impaired angiogenesis. However, current are complicated need on-demand sequential release synergy of multicomponents. Herein, H2S-releasing cascade nanozyme (FeS@Au), which is composed ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), developed single component regulate glucose level, eliminate promote angiogenesis, achieving for diabetic treatment. The oxidase-like activity AuNC catalyzes into gluconic acid H2O2, not only lowers the local level but also decreases pH increases H2O2 boost peroxidase-like FeSNP generate abundant hydroxyl radical (reactive oxygen species, ROS), inducing ferroptosis-like death in drug-resistant bacteria. Additionally, H2S acidified environment upregulate hypoxia-inducible factor-1 enhance vascularization through upregulating expression vascular endothelial growth factor (VEGF) other angiogenesis-related genes, reducing damage cells caused by excessive ROS produced nanozyme. In full-thickness MRSA-infected rat model, FeS@Au significantly eliminates bacteria, enhances promotes collagen deposition, accelerates healing. This work with H2S-release interventions, providing versatile strategy extensive tissue diabetes.

Language: Английский

Citations

0
Morin hydrate reduces survival and fertility, delays development and weakens lipid reserves in Aedes aegypti DOI Creative Commons
Luan Valim dos Santos, Elaine Rodrigues Miranda Nery da Silva, Matheus Silva Caiado

et al.

Medical and Veterinary Entomology, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract The Aedes aegypti mosquito is generally associated with arboviruses that cause yellow fever, dengue, zika and chikungunya. most efficient way to control their populations through application in breeding sites of highly toxic insecticides can also impact non‐target organisms generate resistant populations. Therefore, the use compounds desirable. Morin hydrate has broad pharmacological applications based on its antioxidant potential, addition not having negative effects mammals. objective present study was investigate morin A. survival, pupation rate, egg laying, triacylglycerol reserves expression proteins related lipid metabolism 24 h after exposure larvae. For this, rearing media containing larvae different concentrations were formulated evaluate lethal concentration. Calculation expected showed LC 25 52.692 μM, 40 111.121 50 174.775 75 575.083 μM 90 1685.936 μM. Twenty‐four hours treatment hydrate, surviving transferred morin‐free water food, rate fertility evaluated. We observed an increase concentration induced a dose‐dependent reduction doubled time survivors reduced number eggs laid by treated females during larval stage approximately 30% at exceeding 100 From (TAG) stock evaluated, evaluating involved metabolism. Larvae TAG 17%, while 175 there more than 33% stocks, 500 61%. Furthermore, lipolytic TAGL1 HSL upregulated, lipogenic FAS1, DGAT1 GPAT1 downregulated. Insulin‐like receptors downregulated, unlike AKHr, which upregulated. These data demonstrate reduces survival affecting did exhibit toxicity toward organisms, demonstrating interesting potential for

Language: Английский

Citations

0