Multifunctional Metal–Phenolic Composites Promote Efficient Periodontitis Treatment via Antibacterial and Osteogenic Properties

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13573 - 13584

Published: March 5, 2024

Periodontitis, a complex inflammatory disease initiated by bacterial infections, presents significant challenge in public health. The increased levels of reactive oxygen species and the subsequent exaggerated immune response associated with periodontitis often lead to alveolar bone resorption tooth loss. Herein, we develop multifunctional metal–phenolic composites (i.e., Au@MPN-BMP2) address nature periodontitis, where gold nanoparticles (AuNPs) are coated networks (MPNs) morphogenetic protein 2 (BMP2). In this design, MPNs exhibit remarkable antibacterial antioxidant properties, AuNPs BMP2 promote osteogenic differentiation marrow mesenchymal stem cells under conditions. rat model treatment Au@MPN-BMP2 leads notable therapeutic outcomes, including mitigated oxidative stress, reduced progression inflammation, prevention These results highlight multifunctionality as promising approach for addressing both microbial causative factors an overactivated response. We envision that rational design will provide versatile nanoplatforms tissue regeneration potential clinical applications.

Language: Английский

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Gold Nanoparticles Modulate Macrophage Polarization to Promote Skeletal Muscle Regeneration

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101653 - 101653

Published: March 12, 2025

Skeletal muscle regeneration is a complex process that depends on the interplay between immune responses and stem cell (MuSC) activity. Macrophages play crucial role in this process, exhibiting distinct polarization states-M1 (pro-inflammatory) M2 (anti-inflammatory)-that significantly affect tissue repair outcomes. Recent advancements nanomedicine have positioned gold nanoparticles (Au NPs) as promising tools for modulating macrophage enhancing regeneration. This review examines of Au NPs influencing behavior, focusing their physicochemical properties, biocompatibility, mechanisms action. We discuss how can promote polarization, facilitating through modulation cytokine production, interaction with surface receptors, activation intracellular signaling pathways. Additionally, we highlight benefits MuSC function, angiogenesis, extracellular matrix remodeling. Despite potential skeletal regeneration, challenges remain optimizing nanoparticle design, developing targeted delivery systems, understanding long-term effects. Future directions should focus personalized medicine approaches combination therapies to enhance therapeutic efficacy. Ultimately, emphasizes transformative regenerative medicine, offering hope improved treatments injuries diseases.

Language: Английский

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Nanoparticle‐Driven Skeletal Muscle Repair and Regeneration Through Macrophage‐Muscle Stem Cell Interaction

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Macrophages are key innate immune cells in the muscle environment of sarcopenia patients, significantly influencing stem cell (MuSC) proliferation and differentiation. However, prolonged activation macrophages can hinder recovery. In this study, it synthesizes lipoic acid-modified gold nanoparticles (LA-Au NPs) varying sizes to evaluate their biocompatibility immunomodulatory effects. The findings demonstrate that LA-Au NPs exhibit excellent with promoted M2 polarization a size-dependent manner. Mechanistically, facilitated metabolic reprogramming by enhancing lysosomal autophagy mitochondrial oxidative phosphorylation. Furthermore, shown chemotax toward MuSCs, regulating via chemokine system, inhibiting MuSC apoptosis, differentiation under inflammatory conditions. vivo studies have confirmed safety efficacy mice. To further enhance effectiveness NPs, investigates delivery strategy involves preconditioning (Mac@Au NPs). Compared direct injection Mac@Au greater benefits for repair. This highlights potential macrophage therapy as promising effective regeneration therapeutic intervention sarcopenia.

Language: Английский

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Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 175, P. 214326 - 214326

Published: April 27, 2025

Language: Английский

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Design and application of antimicrobial nanomaterials in the treatment of periodontitis

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 5, 2025

Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy scaling root planning periodontitis promising strategy. However, this administration method's effectiveness constrained complexity environment. Nanomaterials have demonstrated significant potential antibacterial treatment periodontitis, attributed their controllable size, shape, surface charge, high design flexibility, reactivity, specific area. In review, we summarize complex microenvironment difficulties explicitly reviewing application strategies nanomaterials with unique properties distinct periodontitis. Furthermore, review discusses limitations current research, proposes feasible solutions, explores prospects for using context.

Language: Английский

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Tectochrysin Alleviates Periodontitis by Modulating M2/M1 Macrophage Ratio and Oxidative Stress Via Nuclear Factor Kappa B/Heme Oxygenase-1/Nuclear Factor Erythroid 2-Related Factor 2 Pathway

Immunological Investigations, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Oct. 29, 2024

Background Tectochrysin suppresses several diseases. In this study, we aimed to explore the effects of tectochrysin ona rat model periodontitis PDS).

Language: Английский

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Recent Progress of Oral Functional Nanomaterials for Intestinal Microbiota Regulation

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(7), P. 921 - 921

Published: July 10, 2024

The gut microbiota is closely associated with human health, and alterations in can influence various physiological pathological activities the body. Therefore, regulation has become an important strategy current disease treatment, albeit facing numerous challenges. Nanomaterials, owing to their excellent protective properties, drug release capabilities, targeting abilities, good biocompatibility, have been widely developed utilized pharmaceuticals dietary fields. In recent years, significant progress made research on utilizing nanomaterials assist regulating for intervention. This review explores latest advancements application of offers insights into future development modulating microbiota.

Language: Английский

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