Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 20, 2024
Abstract
During
the
implantation
process
of
cardiovascular
implants,
vascular
damage
caused
by
inflammation
occurs,
and
inflammatory
is
accompanied
oxidative
stress.
Currently,
carbon
monoxide
(CO)
has
been
demonstrated
to
exhibit
various
biological
effects
including
vasodilatation,
antithrombotic,
anti-inflammatory,
apoptosis-inducing
antiproliferative
properties.
In
this
study,
hemoglobin/epigallocatechin-3-gallate
(EGCG)
core-shell
nanoparticle-containing
coating
on
stainless
steel
was
prepared
for
CO
loading
modulation.
Inspired
strong
coordination
ability
with
CO,
hemoglobin
nanoparticle
first
encapsulated
into
EGCG
metal-phenolic
networks.
A
polydopamine
(PDA)
linking
layer
then
coated
316
steel,
hemoglobin/EGCG
nanoparticles
were
loaded
subsequent
PDA
deposition.
It
showed
that
maximum
release
amount
17.0
nmol/cm2
in
48
h.
vitro
evaluations
conducted
a
simulated
environment
revealed
coating,
which
released
from
nanoparticles,
effectively
mitigated
lipopolysaccharide-induced
response
macrophages.
Specifically,
it
decreased
expression
tumor
necrosis
factor-α,
increased
interleukin-10,
suppressed
polarization
macrophages
toward
M1
phenotype
reduced
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
under
stress
conditions,
apoptosis
endothelial
cells
induced
down-regulated
ROS
levels.
vivo
results
further
confirmed
its
capabilities,
macrophage-mediated
responses
modulated
The
overuse
of
antibiotics
has
increased
the
prevalence
drug-resistant
bacteria
in
periodontitis.
"Sentinel"
gingival
fibroblasts,
stimulated
by
pathogenic
bacteria,
continue
to
release
signaling
factors
that
affect
stem
cell
repair
and
recruit
immune
cells,
resulting
persistent
inflammation
periodontal
tissues,
eventually
leading
loosening
loss
teeth.
Periodontal
cause
surface
hypoxia,
fibroblasts
inflammatory
microenvironment
express
HIF-1α,
promoting
hypoxic
areas
pockets.
No
drug
delivery
system
is
available
for
region
We
synthesized
BI
NPs
via
berberine
(BBR)
indocyanine
green
(ICG)
formed
BIP
wrapping
with
polydopamine
(PDA),
were
delivered
pocket
hitchhiking
anaerobic
probiotic
Bifidobacterium
bifidum
(Bif).
released
berberin
under
near-infrared
(NIR)
irradiation,
which
inhibited
sulfur
metabolism
Porphyromonas
gingivalis
mild
photothermal
action
BBR-targeted
serine
acetyltransferase,
a
decrease
resistance
oxidative
stress,
thus
exerting
nonantibiotic
bacteriostatic
effect.
This
effect
facilitated
uptake
bygingival
fibroblasts.
Moreover,
BBR
targeted
nuclear
factor-erythroid
2-related
factor
2
(NRF2)
reduce
ferroptosis,
fibroblast
supernatant
modulated
macrophage
polarization
through
NF-κB
pathway.
In
periodontitis
rat
model,
Bif@BIP+NIR
treatment
carried
deep
pockets,
decreasing
local
ferroptosis
alleviating
symptoms.
To
summarize,
engineered
probiotics
target
low-oxygen
pockets
delivery,
P.
bacterial
inhibition,
mitigate
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(23), P. 29844 - 29855
Published: June 3, 2024
Copper
plays
critical
roles
as
a
metal
active
site
cofactor
and
metalloallosteric
signal
for
enzymes
involved
in
cell
proliferation
metabolism,
making
it
an
attractive
target
cancer
therapy.
In
this
study,
we
investigated
the
efficacy
of
polydopamine
nanoparticles
(PDA
NPs),
classically
applied
removal
from
water,
therapeutic
strategy
depleting
intracellular
labile
copper
pools
triple-negative
breast
models
through
metal-chelating
groups
present
on
PDA
surface.
By
using
activity-based
sensing
probe
FCP-1,
could
track
PDA-induced
depletion
while
leaving
total
levels
unchanged
link
to
selective
MDA-MB-231
death.
Further
mechanistic
investigations
revealed
that
NPs
increased
reactive
oxygen
species
(ROS)
levels,
potentially
inactivation
superoxide
dismutase
1
(SOD1),
copper-dependent
antioxidant
enzyme.
Additionally,
were
found
interact
with
mitochondrial
membrane,
resulting
increase
membrane
potential,
which
may
contribute
enhanced
ROS
production.
We
employed
vivo
tumor
model
validate
NPs.
Remarkably,
absence
any
additional
treatment,
presence
alone
led
significant
reduction
volume
by
factor
1.66
after
22
days
growth.
Our
findings
highlight
potential
promising
approach
selectively
targeting
modulating
inducing
oxidative
stress,
leading
growth
inhibition
shown
these
models.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Sept. 13, 2024
Piezoelectric
materials,
as
a
class
of
materials
capable
generating
electrical
charges
under
mechanical
vibration,
have
special
piezoelectric
effects
and
been
widely
applied
in
various
disease
treatment
fields.
People
generate
vibrations
the
oral
cavity
during
daily
activities
such
brushing
teeth,
using
electric
toothbrushes,
chewing,
speaking.
These
natural
(or
external
ultrasound)
provide
ideal
conditions
for
activating
leading
to
their
high
potential
applications
protecting
health
treating
diseases.
Based
on
this,
this
review
reports
research
progress
trends
protection
diseases
past
5
years,
discusses
its
mechanism,
challenges
shortcomings,
aiming
theoretical
basis
new
ideas
future
application
field
cavity.
Finally,
brief
outlook
is
provided,
suggesting
that
may
enable
them
quickly
move
towards
real
clinical
applications.
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Abstract
Providing
oxygen
and
preventing
infection
at
wound
sites
are
effective
ways
to
heal
diabetic
chronic
wounds.
Inspired
by
natural
lichens,
a
bioprinted
biogenic
hydrogel
(BBH)
containing
microalgae
probiotics
is
developed
for
therapeutics,
which
offers
prolonged
biogenetic
supply
inhibition
probiotics.
The
rational
design
of
symbiotic
BBH
with
customizable
structure
microorganism
composition
enhances
resilience
against
elevated
glucose
levels
hypoxia,
leading
the
increased
migration
ability
fibroblasts
angiogenic
potential
human
umbilical
vein
endothelial
cells.
Notably,
BBH‐treated
wounds
exhibit
dense
vascular
distribution,
reduced
hypoxia
inflammatory
responses,
enhanced
epithelial
differentiation
keratinization
abilities.
Consequently,
achieves
rapid
tissue
repairing
within
3
d
restores
approximately
90%
whole
skin
12
d.
This
work
presents
an
engineered
platform
regulating
biological
microenvironment
provides
insights
developing
hybrid
systems.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 20, 2024
Abstract
During
the
implantation
process
of
cardiovascular
implants,
vascular
damage
caused
by
inflammation
occurs,
and
inflammatory
is
accompanied
oxidative
stress.
Currently,
carbon
monoxide
(CO)
has
been
demonstrated
to
exhibit
various
biological
effects
including
vasodilatation,
antithrombotic,
anti-inflammatory,
apoptosis-inducing
antiproliferative
properties.
In
this
study,
hemoglobin/epigallocatechin-3-gallate
(EGCG)
core-shell
nanoparticle-containing
coating
on
stainless
steel
was
prepared
for
CO
loading
modulation.
Inspired
strong
coordination
ability
with
CO,
hemoglobin
nanoparticle
first
encapsulated
into
EGCG
metal-phenolic
networks.
A
polydopamine
(PDA)
linking
layer
then
coated
316
steel,
hemoglobin/EGCG
nanoparticles
were
loaded
subsequent
PDA
deposition.
It
showed
that
maximum
release
amount
17.0
nmol/cm2
in
48
h.
vitro
evaluations
conducted
a
simulated
environment
revealed
coating,
which
released
from
nanoparticles,
effectively
mitigated
lipopolysaccharide-induced
response
macrophages.
Specifically,
it
decreased
expression
tumor
necrosis
factor-α,
increased
interleukin-10,
suppressed
polarization
macrophages
toward
M1
phenotype
reduced
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
under
stress
conditions,
apoptosis
endothelial
cells
induced
down-regulated
ROS
levels.
vivo
results
further
confirmed
its
capabilities,
macrophage-mediated
responses
modulated
