ACS Applied Polymer Materials,
Journal Year:
2024,
Volume and Issue:
6(22), P. 13764 - 13774
Published: Nov. 8, 2024
The
infected
microenvironment
provides
fertile
ground
for
bacterial
growth
and
the
progression
of
inflammation,
making
it
challenging
to
cure
related
diseases.
Here,
a
covalent
organic
polymer
(COP)-based
antibacterial
agent,
denoted
as
PF-COP,
was
developed.
PF-COP
has
intrinsic
photothermal
capacity,
which
allows
take
advantage
enhanced
synergistic
wound
infection
therapy.
prepared
via
copolymerization
piperazine
with
ferrocene
diformaldehyde
using
catalyst-free
aminal
chemistry,
in
units
could
easily
bind
acid
generate
cationic
skeleton,
while
components
convert
endogenous
H2O2
into
toxic
hydroxyl
radical.
This
effectively
regulates
microenvironment.
acidified
positively
charged
structures
enhance
material
adhesion
cell
membranes
improve
responsiveness,
significantly
improving
therapeutic
effect.
As
result,
amalgamating
enzyme
catalytic
capacities
serve
an
microenvironment-enhanced
agent.
It
disrupt
balance
microenvironment,
destroying
optimal
environment
bacteria
inducing
"bacterial
suicide",
regulate
promote
normal
cells,
thus
accelerating
healing.
Therefore,
this
work
presents
promising
construction
strategy
precise
development
COP-based
therapeutics
facilitating
healing
through
direct
infectious
utilization
regulation.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Janus
hydrogels
have
promising
applications
in
tendon
healing
and
anti-peritendinous
adhesions.
However,
their
complicated
preparation
methods,
weak
mechanical
properties,
unstable
adhesion
interfaces
severely
limited
application
suture-free
high-quality
healing.
In
this
work,
by
controlling
the
interfacial
distribution
of
free
-COOH
groups
cationic-π
structures
on
both
sides
hydrogels,
a
series
PZBA-EGCG-ALC
with
varying
degrees
asymmetric
properties
are
successfully
prepared
using
simple
efficient
one-step
synthesis
method.
The
tensile
strength
elongation
at
break
hydrogel
as
high
0.51
±
0.04
MPa
922.89
28.59%.
addition,
can
achieve
difference
(nearly
20-fold)
while
maintaining
strong
bottom
(up
to
524.8
33.1
J
m-2).
spatial
dimension,
its
excellent
compliance
one-sided
behavior
provide
effective
support
physical
barriers
for
injured
Achilles
tendons.
More
importantly,
also
minimize
early
inflammation
generation
time
dimension
via
ROS-responsive
PZBA-EGCG
prodrug
macromolecules.
This
study
provided
more
convenient
strategy
constructing
promote
Materials Horizons,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The
mechanical
properties
of
polymer
elastomer
materials,
such
as
strength
and
ductility,
play
important
roles
in
a
wide
range
applications,
including
the
carrying
major
equipment
construction
infrastructure.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
To
alleviate
the
discomfort
caused
by
excessive
sweating,
there
is
a
growing
emphasis
on
developing
wearable
textiles
that
can
evacuate
sweat
autonomously.
These
advanced
fabrics,
unlike
their
absorbent
and
retention-prone
predecessors,
harness
Janus
structure-distinguished
its
asymmetric
wettability-to
facilitate
one-way
transport
of
liquid.
This
unique
characteristic
has
significant
potential
in
addressing
issues
related
to
bodily
moisture
propelling
realm
smart
wearables.
review
offers
comprehensive
overview
advancements
Janus-structured
within
field,
delving
into
mechanisms
behind
unidirectional
liquid
transport,
which
rely
chemical
gradient
curvature
strategies,
alongside
methodologies
for
achieving
wettability.
It
further
spotlights
multifaceted
applications
Janus-based
wearables,
including
thermal
management,
wound
care,
analysis.
In
addition
examining
existing
hurdles,
also
explores
avenues
future
innovation,
envisioning
new
era
tailored
personalized
comfort
health
monitoring
capabilities.
Cell Reports Physical Science,
Journal Year:
2024,
Volume and Issue:
5(7), P. 102053 - 102053
Published: June 17, 2024
Facing
the
problems
encountered
in
contemporary
hard
and
soft
tissue
repair,
need
for
better
solutions
has
never
been
so
pressing.
Traditional
repair
methods
often
fall
short,
leading
to
disappointing
therapeutic
outcomes
complications.
To
address
associated
with
engineering,
polyurethane
stands
out
because
of
its
remarkable
adaptability
healing
potential.
This
review
embarks
on
a
journey
through
essential
properties
diverse
classifications
polyurethane,
unveiling
modification
strategies
that
amplify
efficacy.
Beyond
process
mending
gaps,
capability
as
sophisticated
drug
delivery
system
is
explored
offer
glimpse
into
versatile
applications.
Most
notably,
cutting-edge
advancements
clinical
trials
bridging
voids
both
are
discussed.
The
present
explores
future
bio-interface
providing
wave
inventive
poised
redefine
landscape
regenerative
medicine.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(28), P. 6968 - 6980
Published: Jan. 1, 2024
Postoperative
adhesions,
a
prevalent
complication
following
abdominal
surgery,
affect
90%
of
patients
undergoing
surgical
procedures.
Currently,
the
primary
approach
to
prevent
postoperative
adhesions
involves
physical
isolation
site
and
surrounding
tissues
using
hydrogel;
however,
this
method
represents
rudimentary
strategy.
Herein,
considering
impact
oxidative
stress
free
radicals
on
adhesion
during
wound
healing,
an
injectable
antioxidant
hydrogel,
named
PU-OHA-D,
was
successfully
synthesized,
which
is
formed
by
crosslinking
dopamine-modified
oxidized
hyaluronic
acid
(OHA-D)
dihydrazide-terminated
polyurethane
(PU-ADH)
through
hydrazone
bonding.
PU-OHA-D
hydrogel
possesses
versatile
characteristics
such
as
rapid
gel
formation,
injectability,
self-repair
capability
biodegradability.
Additionally,
they
exhibit
excellent
ability
clear
superior
tissue
adhesion.
can
be
injected
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(42), P. 56862 - 56873
Published: Oct. 14, 2024
Thermoplastic
polyurethanes
(TPUs)
are
one
of
the
most
appealing
materials
with
extensive
applications
in
biomedical
fields
due
to
their
versatile
mechanical
properties
and
excellent
biocompatibility.
In
response
escalating
challenges
bacterial
infections,
it
is
desirable
obtain
TPUs
intrinsic
antibacterial
activity,
particularly
for
application
devices
public
places.
Herein,
a
cationic
main-/side-chain
structure
regulation
strategy
TPU
hard
segment
was
adopted
introduce
optimize
activity.
This
achieved
by
synthesizing
two
types
quaternary
ammonium
salts
(QAS)-containing
chain
extenders,
i.e.,
N-methyl-N-alkyl-N,N-bis(2-hydroxyethyl)
bromide
(Mn,
where
n
represents
N-alkyl
length)
N,N-dimethyl-N-alkyl-N-2,3-propylene
glycol
(Dn),
from
N-methyldiethanolamine
(MDEA)
3-dimethylamino-1,2-propanediol
(DMAD),
respectively.
Given
structural
differences
between
Mn
Dn,
main-chain-type
PU-Mn
side-chain-type
PU-Dn
were
subsequently
obtained
QAS
groups
segment.
The
length,
content,
systematically
investigated
bactericidal
properties.
results
revealed
that
long
(from
C6
C14)
increased
activity
extenders
corresponding
films.
Besides,
films
showed
higher
contact-active
than
exerted
Remarkably,
almost
100%
Staphylococcus
aureus(S.
aureus)
could
be
killed
PU-D14
film
low
content
(1.6
wt
%).
All
good
thermal
stability
degradation
temperature
5%
mass
loss
(Td,5%)
above
300
°C.
Moreover,
displayed
tensile
strength
at
break
varying
20.7
47.5
MPa
ultimate
elongation
1000%.
negligible
hemolytic
activities.
