Food Chemistry, Journal Year: 2024, Volume and Issue: 467, P. 142260 - 142260
Published: Nov. 28, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575
Published: Sept. 7, 2024
Language: Английский
Citations
5
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Chinese herbal medicine has offered a great treasure for discovering intrinsically bioactive low molecular weight gelators (LMWGs). Herein, the two-component hydrogels comprising glycyrrhizic acid (GA) and puerarin (PUE), primary components, respectively, from herbs Glycyrrhiza uralensis Fisch Pueraria lobata are successfully prepared. Combined spectroscopic characterizations reveal that hydrogen bonds formed between GA PUE molecules, which further drives growth of nanofiber assemblies into gel networks. Importantly, micromorphological observation by scanning electron microscopy (SEM), synchrotron small-angle X-ray scattering (SAXS), dynamic simulation suggest coassembly pathway is involved in gelling process. Such exhibit good injectable, self-healing, adhesive properties. Interestingly, mixed GA-PUE demonstrate more efficient selective antibacterial activity toward S. aureus instead E. coli, ratio-dependent also observed. Our work highlights CHM-derived LMWGs can provide scaffold developing multicomponent hydrogels, may afford novel distinct properties compared with their individual ones. It assumed supramolecular derived CHM would appear to better address challenges, particularly biomedical field.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 1 - 16
Published: Feb. 3, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141896 - 141896
Published: March 1, 2025
Language: Английский
Citations
0
Supramolecular Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100081 - 100081
Published: Nov. 1, 2024
Language: Английский
Citations
3
Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Natural small-molecule drugs have been used for thousands of years the prevention and treatment human diseases. Most natural products available on market modified into various polymer materials improving solubility, stability, targeted delivery drugs. However, these nanomedicines formed based carriers would produce severe problems such as systemic toxicity kidney metabolic stress. In contrast, carrier-free by their self-assembly in water inherent advantages low toxicity, good biocompatibility, biodegradability. This review summarizes assembly process application products, which are mainly driven multiple non-covalent interactions, includes single-molecule assembly, bimolecular drug-modified organogels. Meanwhile, molecular mechanism involved different processes is also discussed. Self-assembly simulation structural modification or traditional Chinese medicine molecules using dynamics computer-assisted methods proposed, will lead to discovery more nanomedicine drug systems. Overall, this provides an important understanding strategy study multi-molecule nanomedicines.
Language: Английский
Citations
1
Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
The popularity of medicinal plants, which have a unique system and are mostly used in compound form for the prevention treatment wide range diseases, is growing worldwide. In recent years, with advances chemical separation structural analysis techniques, many major bioactive molecules plants been identified. However, active ingredients often possess characteristics, including poor water solubility, stability bioavailability, limit their therapeutic applications. To address this problem, self-assembly small from food sources provides new strategy. Driven by various types acting forces, modifiable groups, multiple sites action, hydrophobic side chains, rigid backbones properties able to supramolecular network hydrogels, nanoparticles, micelles, other self-assemblies. This review first summarizes forms self-assemblies such as micelles at level action site, discusses studies on that can be self-assembly, addition summarizing advantages variety disease applications, wound healing, antitumor, anticancer, diabetes mellitus. Finally, problems self-assemblers possible directions future development presented. We firmly believe potential develop effective compounds drug-food homologous providing valuable information drug research strategies perspectives modernization Chinese medicine.
Language: Английский
Citations
1
Food Chemistry, Journal Year: 2024, Volume and Issue: 467, P. 142260 - 142260
Published: Nov. 28, 2024
Language: Английский
Citations
1