Recent studies of the effects of microgravity on cancer cells and the development of 3D multicellular cancer spheroids

Stem Cells Translational Medicine, Journal Year: 2025, Volume and Issue: 14(3)

Published: March 1, 2025

Abstract The still young and developing space age, characterized by lunar Martian exploration the vision of extraterrestrial settlements, presents a unique environment to study impact microgravity (µg) on human physiology disease development. Cancer research is currently key focus international science, as µg fundamentally impacts cellular processes like differentiation, adhesion, migration, proliferation, survival, cell death, or growth cancer cells well cytoskeleton extracellular matrix (ECM). By creating three-dimensional (3D) tumor models in µg-environment, multicellular spheroids (MCS), researchers can expedite drug discovery development, reducing need for animal testing. This concise review analyses latest knowledge influence MCS formation. We will from brain tumors, lung, breast, thyroid, prostate, gastrointestinal, skin exposed real (r-) simulated (s-) µg-conditions.

Language: Английский

Construction of a pumpless gravity-driven vascularized Skin-on-a-Chip for the study of hepatocytotoxicity in percutaneous exposure to exogenous chemicals

Biomedical Microdevices, Journal Year: 2024, Volume and Issue: 26(4)

Published: Sept. 20, 2024

Language: Английский