Piezoelectric Iridium-Doped Bismuth Ferrite/Sodium Alginate Hydrogel for Antibiosis and Stimulating Osteoblastic Differentiation

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

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NF-κB-Signaling-Targeted Immunomodulatory Nanoparticle with Photothermal and Quorum-Sensing Inhibition Effects for Efficient Healing of Biofilm-Infected Wounds

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(20), P. 25757 - 25772

Published: May 13, 2024

The development of therapeutics with high antimicrobial activity and immunomodulatory effects is urgently needed for the treatment infected wounds due to increasing danger posed by recalcitrant-infected wounds. In this study, we developed light-controlled antibacterial, photothermal, biomimetic N/hPDA@M nanoparticles (NPs). This nanoplatform was loading flavonoid naringenin onto hollow mesoporous polydopamine NPs in a π-π-stacked configuration encasing them macrophage membranes. First, our efficiently neutralized inflammatory factors present within wound microenvironment integration Afterward, effectively dismantled bacterial biofilms through combination photothermal properties PDA quorum sensing inhibitory naringenin. It worth noting that near-infrared-enhanced release exhibited specificity toward NF-κB-signaling pathway, mitigating response. innovative design not only conferred remarkable antibacterial upon but also endowed capacity modulate responses, curbing excessive inflammation steering polarization M2 phenotype. As result, multifaceted approach significantly contributes expediting healing process skin

Language: Английский

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Construction of self‐healing gallium (III)‐cross‐linked konjac glucomannan/polyacrylamide hydrogels for efficiently killing bacteria and accelerating wound healing

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: 141(32)

Published: May 24, 2024

Abstract Gallium ions have a special action mechanism that interferes bacterial iron metabolism, thereby possessing great potential for the treatment of infections. In this work, gallium ions‐cross‐linked konjac glucomannan/polyacrylamide (KGM/PAM/Ga 3+ ) hydrogels are successfully constructed with satisfactory swelling ability, appropriate mechanical properties and adjustable degradation performance. Ga as kind cross‐linking agent can enhance stability, more importantly, improve bactericidal ability hydrogel, thus forming novel functional KGM/PAM/Ga treating wounds. After evaluation antibacterial activity biocompatibility, effectively inhibit proliferation bacteria through gradual sustainable release from hydrogel negligible cytotoxicity good blood compatibility. Furthermore, they possess exceptional self‐healing behavior, be readily adapted to varying degrees bending, which matches skin wound dressing application. Finally, results healing performance histological demonstrate efficiently accelerate infected facilitate regeneration tissues.

Language: Английский

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Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Oct. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Language: Английский

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Revolutionizing healthcare: inorganic medicinal nanoarchitectonics for advanced theranostics

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 10(3), P. 460 - 483

Published: Nov. 22, 2024

Over the last two decades, advancements in nanomaterials and nanoscience have paved path for emergence of nano-medical convergence science, significantly impacting healthcare. In our review, we highlight how these are applied various biomedical technologies such as drug delivery systems, bio-imaging diagnostic therapeutic purposes. Recently, novel inorganic nanohybrid drugs been developed, combining multifunctional with agents (known medicinal nanoarchitectonics). These innovative actively utilized cutting-edge medical treatments, including targeted anti-cancer therapy, photo radiation immunotherapy. This review provides a detailed overview current development status nanoarchitectonics explores potential future directions their advancements.

Language: Английский

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Nanozyme-based therapeutic strategies for rheumatoid arthritis

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 716 - 734

Published: Dec. 3, 2024

Language: Английский

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NIR-II/pH Dual Responsive CuHDB@CaP Nanospheres as a Self-Cascading Catalytic Platform for Highly Efficient Combating Bacterial Infections

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

The misuse of antibiotics has led to a dramatic increase in bacterial resistance, creating an urgent need for efficient antimicrobial agents with multiple mechanisms action. In this study, Cu was modified berberine derivatives, and core–shell structure successfully developed, resulting light/pH-responsive CuHDB@CaP nanotherapeutic platform. It achieves controlled release CuHDB nanozymes, CaP, which is highly stable neutral or alkaline environments, preventing leakage effectively "switching off" the activity nanozymes. Bacterial metabolism, produces lactic keto acids, lowers pH wound microenvironment. Additionally, exposure 1064 nm near-infrared (NIR) light causes CaP shell collapse, releasing nanozymes on" their enzyme-like activity. This enables platform be both safe efficient. exhibits not only strong photothermal effect but also enhanced glutathione oxidase (GSHOx)-like peroxidase (POD)-like enzyme activities. GSHOx-like contributes generation H2O2, its excellent H2O2 affinity allows it efficiently catalyze conversion sufficient amount •OH through POD-like self-cascading catalytic does require introduction additional promotes consumption GSH infection can kill up 99.0% MRSA AmprE. coli, inhibit biofilm formation without emergence drug exhibit negligible cytotoxicity hemolysis. Treatment experiments mouse models showed that combined NIR could treat infections accelerate healing minimal toxicity normal tissue cells, demonstrating potential clinical treatment skin infections.

Language: Английский

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Multifaceted Role of Nanocomposite Hydrogels in Diabetic Wound Healing: Enhanced Biomedical Applications and Detailed Molecular Mechanisms

Biomaterials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Nanocomposite hydrogels offer a promising approach to treating diabetic wounds. Key findings include enhanced mechanical properties, antibacterial effects, and the ability regulate wound microenvironment.

Language: Английский

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