Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor‐Targeted Type‐I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

It is highly desired to achieve Type-I photosensitizer (PS) overcome the hypoxic limitation found in most clinically used PSs. Herein, a new heavy-atom-free PS T-BNCy5 presented by incorporating biotin-modified naphthalimide (NI) unit into meso-position of N-benzyl-functionalized, strongly photon-capturing pentamethine cyanine (Cy5) dye. Such molecular engineering induces rigid orthogonal geometry between NI and Cy5 units introducing an intramolecular sandwich-like π-π stacking assembly, which effectively promotes intersystem crossing (ISC) greatly extends triplet-state lifetime (τ = 389 µs), thereby markedly improving superoxide (O2 •-)-generating ability. In vitro assays reveal that specifically accumulates mitochondria, where it not only generates O2 •- under photoirradiation but also burst cytotoxic hydroxy radical (HO•) cascade biochemical reactions, ultimately triggering cell ferroptosis with IC50 value up ≈0.45 µm whether normoxia or hypoxia. vivo manifest that, benefiting from its biotin unit, displays strong tumor-targeting ability, after single PDT treatment, can ablate tumor almost completely be cleared body through biosafe urinary excretion, indicating potential for future clinical translation.

Language: Английский

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Augmenting heptamethine cyanine photosensitivity while retaining strong fluorescence emission: Forming dye-albumin nanocomplex enables tumor-targeted photodynamic therapy

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111141 - 111141

Published: March 1, 2025

Language: Английский

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Triarylphosphonium BODIPY‐Based [2]Rotaxanes Nanoparticles for Light‐Driven Antibacterial Applications

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Antimicrobial photodynamic therapy (aPDT) is a promising strategy to overcome issues related antibiotic resistance. Here the rationale for designing new photosensitizers described based on functionalization of bodipy dyes with triarylphosphonium rotaxanes, and an in‐depth characterization their photophysical properties, applying different spectroscopic techniques, including ultrafast transient absorption spectroscopy provided. While addition halogen atoms some structures provides them ability efficiently produce singlet oxygen in organic solvents, such property suppressed water, where all investigated compounds aggregate into spherical nanoparticles. The latter, independently presence bromine, demonstrate high photothermal conversion efficiency have been tested as antibacterial therapy, highlighting potential self‐assembled nanostructures developing versatile nanomaterials photomedicine applications.

Language: Английский

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Dinuclear Ir(III)-Oligomer as a Sunlight-Driven Hydroxyl Radical Generator for Effective Cancer Photodynamic Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: June 2, 2025

An interesting sunlight-driven photodynamic therapy (PDT) has been realized. In this study, we propose a strategy involving an intramolecular electron-donating ligand to develop high-performance type-I photosensitizer. Specifically, electron-rich core is flanked by two iridium atoms, facilitating electron transfer and promoting hydroxyl radical generation. The resulting Ir(III) photosensitizer, Q-T, boosts the rapid generation of reactive oxygen species (ROS) under low-intensity laser exposure. Moreover, ROS ideally suits hypoxic microenvironments, thus demonstrating remarkable PDT against various cell lines, artificial natural sunlight. skin squamous carcinoma (A431) organoid model, one cycle treatment dosing Q-T followed sunlight irradiation effectively induces cellular apoptosis completely eradicates tumor organoids. This approach offers promising avenue for efficient cancer utilizing

Language: Английский

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NIR-activated multifunctional agents for the combined application in cancer imaging and therapy

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 336, P. 103356 - 103356

Published: Nov. 22, 2024

Language: Английский

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