Mechanical structure design: A survey on modern triboelectric nanogenerators

Applied Energy, Journal Year: 2025, Volume and Issue: 391, P. 125918 - 125918

Published: April 17, 2025

Language: Английский

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Fabrication and tribological mechanism of grease-containing self-lubricating composite epoxy coatings

Tribology International, Journal Year: 2025, Volume and Issue: unknown, P. 110734 - 110734

Published: April 1, 2025

Language: Английский

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Biomolecular Condensates Based on Amino Acid for Enhancing Oral Bioavailability and Therapeutic Efficacy of Hydrophobic Drugs

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58370 - 58378

Published: Oct. 15, 2024

The oral administration of chemo- or immunotherapeutic drugs presents a compelling alternative for patients with malignant colorectal cancer, offering convenient and patient-compliant "hospital-free" strategy. Unfortunately, the hydrophobic nature many drug candidates, alongside harsh conditions gastrointestinal tract, frequently results in suboptimal bioavailability heightened systemic toxicity. To address these challenges, we harnessed unique properties biomolecular condensates, which form through liquid–liquid phase separation mechanism, to develop versatile platform encapsulation delivery. In this study, introduce reliable effective amorphous delivery system based on condensates derived from amino acid derivative N-(benzyloxycarbonyl)-l-proline (ZP). These ZP exhibit dynamic intermolecular interactions possess physicochemical attributes such as fluidity viscoelasticity. They significantly improve solubility drugs, ensuring enhanced stability optimized pharmacokinetics under physiological conditions. By maintaining an state, substantially increased markedly improved pharmacokinetics. Furthermore, demonstrate potential integrated therapeutic capable potentiating synergies between chemotherapy immunotherapy while concurrently reducing This has resulted significant enhancement chemo-immunotherapy efficacy treatment representing notable advancement oncology.

Language: Английский

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Nonspherical Particle Stabilized Emulsions Formed through Destabilization and Arrested Coalescence

Langmuir, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

To form nonspherical emulsion droplets, the interfacial tension driving droplet sphericity must be overcome. This can achieved through particle jamming; however, careful control of coverage is required. In this work, we present a scalable novel batch process to particle-stabilized emulsions. by concurrently forming interfacially active particles and drastically accelerating destabilization addition electrolyte. achieve this, surfactant-stabilized oil-in-water emulsions in presence dopamine were first produced. These then treated with tris(hydroxymethyl)aminomethane hydrochloride buffer both simultaneously initiate polymerization continuous phase reduce Debye length system, thus coalescence while surface-active particles. The concentration imposed shear was systematically varied, behavior at interface studied using pendent drop tensiometry rheology. It found that polydopamine nanoparticles formed adsorbed reducing during coalescence, resulting anisotropic droplets via arrested coalescence. Greater rates resulted accelerated formation secondary whereas lower thicker films. efficacy method further demonstrated second system consisting sodium dodecyl sulfate as surfactant polypyrrole particles, which also for optimized conditions.

Language: Английский

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Visually monitoring of wear damage and interfacial corrosion in lubricant coating enabled by MXene@Rhodamine B fluorophores

Carbon, Journal Year: 2024, Volume and Issue: unknown, P. 119962 - 119962

Published: Dec. 1, 2024

Language: Английский

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