Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: unknown, P. 113599 - 113599
Published: Nov. 1, 2024
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 495 - 523
Published: Nov. 29, 2024
Language: Английский
Citations
3
Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18
Published: Jan. 29, 2025
The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Photodynamic transition metal complexes leveraging unique properties metals enhance aPDT activity are next-generation PS. review provides an overview metal-based PS Based on structures, these metal-PS could be mainly classified as metal-tetrapyrrole derivatives, ruthenium complexes, iridium and zinc complexes. based other such silver, cobalt, rhenium also presented. Finally, we summarize advantages shortcomings metal- PS, conclude some critical aspects impacting their performances give perspective future development.
Language: Английский
Citations
0
Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 6, 2025
Herein, five Fe(II) complexes, viz., [Fe(N,N,N)2](ClO4)2, where N,N,N = 4′-phenyl-2,2′:6′,2″-terpyridine (Ph-tpy, Fe1), 4′-(4 aminophenyl) 2,2′:6′,2″ terpyridine (NH2-Phtpy, Fe2), 4-([2,2′:6′,2′′-terpyridin]-4′-yl)-N,N-dimethylaniline (NMe2-Phtpy, Fe3), 4′-(p-nitrophenyl)-2.2′:6′,2″-terpyridine (NO2-Phtpy, Fe4), and 4′-(4-trifluoromethylphenyl)-2,2':6′,2′′-terpyridine (CF3-Phtpy, Fe5) were developed screened for their visible-light-triggered antibacterial activity. Fe1–Fe5 exhibited absorption at ca. 450–600 nm, beneficial photodynamic therapy (aPDT) under visible light exposure. The excellent photostability ideal energy gap between T1 S0 of the complexes made them good photosensitizers aPDT. Fe5 had best activity against Escherichia coli Bacillus subtilis upon exposure to 400–700 nm (10 J cm–2) due reactive oxygen species (ROS) generation. Further, showed antibiofilm on different medical-grade biomaterials devices. Biocompatibility was validated using in vivo chicken embryonic models (in ovo). Moreover, studies that efficiently healed infected wounds within 9 days.
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Language: Английский
Citations
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136563 - 136563
Published: March 1, 2025
Language: Английский
Citations
0
Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114676 - 114676
Published: May 1, 2025
Language: Английский
Citations
0
Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 11, 2024
Abstract Three novel polypyridyl‐Co(III)‐vitamin B 6 complexes viz ., [Co(CF 3 ‐phtpy)(SBVB )]Cl ( Co1 ), [Co(anthracene‐tpy)(SBVB Co2 [Co(NMe 2 Co3 where 4’‐(4‐(trifluoromethyl)phenyl)‐2,2’:6’,2’’‐terpyridine=CF ‐phtpy, 4’‐(anthracen‐9‐yl)‐2,2’:6’,2’’‐terpyridine=anthracene‐tpy;, 4‐([2,2’:6’,2’’‐terpyridin]‐4’‐yl)‐N,N‐dimethylaniline=NMe (E)‐5‐(hydroxymethyl)‐4‐(((2‐hydroxyphenyl)imino)methyl)‐2‐methylpyridin‐3‐ol=H SBVB were successfully developed for aPDT (antibacterial photodynamic therapy) applications. – exhibited an intense absorption band at ca . 435–485 nm, which is attributed to ligand‐to‐metal charge transfer and was beneficial antibacterial therapy. The distorted octahedral geometry of the with Co III N 4 O core evident from DFT study. visible light ability good photo‐stability made them photosensitizers aPDT. displayed significant responses against gram‐positive S. aureus ) gram‐negative E. coli bacteria upon exposure (10 J cm −2 , 400–700 nm) showed MIC values between 0.01–0.005 μg mL −1 activities these due their damage bacterial cell membranes via ROS generation. Overall, this study shows photo‐triggered ROS‐mediated bacteria‐killing potential Co(III) complexes.
Language: Английский
Citations
2
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Sonodynamic therapy (SDT) can generate reactive oxygen species (ROS) to combat multidrug-resistant biofilms, which pose significant challenges human health. As the key producing ROS in SDT, design of sonosensitizers with optimal molecular structures for sufficient generation and activity complex biofilm matrix is essential. In this study, we propose a π-expansion strategy synthesize series small-molecule metal Ru(II) complexes (
Language: Английский
Citations
2
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 12, 2024
A quercetin nanocrystal containing alginate hydrogel patch demonstrates rapid wound healing of skin wounds in rat and mouse models.
Language: Английский
Citations
2
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 6101 - 6113
Published: Aug. 9, 2024
Bacterial infections and biofilm growth are common mishaps associated with medical devices, they contribute significantly to ill health mortality. Removal of bacterial deposition from these devices is a major challenge, resulting in an immediate necessity for developing antibacterial coatings on the surfaces implants. In this context, we developed innovative coating strategy that can operate at low temperatures (80 °C) preserve devices' integrity functionality. An Ag-TiO
Language: Английский
Citations
1