Long Non-Coding RNAs in Stem Cell Regulation and Regenerative Medicine: Stemness, Differentiation, and Therapeutic Innovation

IntechOpen eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Long non-coding RNAs (lncRNAs) have emerged as critical regulators in stem cell biology, influencing cellular functions such pluripotency, differentiation, and self-renewal. Their unique ability to modulate gene expression at multiple levels—epigenetic, transcriptional, post-transcriptional—makes lncRNAs powerful tools for controlling fate. In regenerative medicine, understanding the roles of specific can enhance therapeutic approaches, particularly cell-based tissue repair engineering. By modulating lncRNA activity, researchers potentially direct differentiation toward desired lineages, facilitating development functional tissues clinical applications. This chapter explores how influence states, highlights current research therapies, discusses potential future applications where lncRNA-based interventions could drive advancements engineering medicine.

Language: Английский

Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer Therapy

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 535 - 535

Published: April 5, 2025

Pharmacogenomics is revolutionizing precision medicine by enabling tailored therapeutic strategies based on an individual genetic and molecular profile. Circular RNAs (circRNAs), a distinct subclass of endogenous non-coding RNAs, have recently emerged as key regulators drug resistance, tumor progression, responses. Their covalently closed circular structure provides exceptional stability resistance to exonuclease degradation, positioning them reliable biomarkers novel targets in cancer management. This review comprehensive analysis the interplay between circRNAs pharmacogenomics, focusing their role modulating metabolism, efficacy, toxicity profiles. We examine how circRNA-mediated regulatory networks influence chemotherapy alter targeted therapy responses, impact immunotherapy outcomes. Additionally, we discuss emerging experimental tools bioinformatics techniques for studying circRNAs, including multi-omics integration, machine learning-driven biomarker discovery, high-throughput sequencing technologies. Beyond diagnostic potential, are being actively explored agents delivery vehicles. Recent advancements circRNA-based vaccines, engineered CAR-T cells, synthetic circRNA therapeutics highlight transformative potential oncology. Furthermore, address challenges standardization, reproducibility, clinical translation, emphasizing need rigorous validation frameworks facilitate integration into practice. By incorporating profiling pharmacogenomic strategies, this underscores paradigm shift toward highly personalized therapies. hold immense overcome enhance treatment optimize patient outcomes, marking significant advancement

Language: Английский

Harnessing Nanomaterials For Enhanced DNA‐Based Biosensing And Therapeutic Performance

ChemBioChem, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The integration of nanomaterials with DNA-based systems has emerged as a transformative approach in biosensing and therapeutic applications. Unique features DNA, like its programmability specificity, complement the diverse functions nanomaterials, leading to creation advanced for detecting biomarkers delivering treatments. Here, we review developments DNA-nanomaterial conjugates, emphasizing their enhanced functionalities potential across various biomedical We first discuss methodologies synthesizing these distinguishing between covalent non-covalent interactions. then categorize DNA-nanomaterials conjugates based on properties DNA involved, respectively. probes are classified by application into or uses, and, several highlighted recent progress living biological. Finally, current challenges future prospects this field, anticipating that significant will greatly enhance precision medicine.

Language: Английский