Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112341 - 112341
Published: Dec. 1, 2024
Language: Английский
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Keloids pose a considerable worldwide health issue owing to their continual proliferation, invasiveness, and elevated recurrence rates. are abnormal scars formed through dysregulated wound healing processes, characterized by excessive keloid fibroblast (KF) irregular collagen deposits, persistent reticular dermis inflammation, which can lead limited joint mobility, psychological distress, severe pain itching. In this study, we present metal–organic framework (MOF)-derived TiO2-based nanoparticles (LA@CTx NPs) synthesized as phototherapy-gas-therapy nanoplatform, have the ability break down collagen, reduce stop overproliferation of fibroblasts. The MIL-125-derived maintain crystalline while being rich in oxygen vacancies (OVs) l-arginine (LA), enabling efficient photothermal conversion reactive species (ROS) generation driven synergistic near-infrared (NIR). Importantly, ROS generated NPs trigger nitric oxide (NO) production oxidizing LA, with concentration NO finely tunable via modulation light conditions. This allows for dual therapeutic effect: low concentrations suppress higher induce cell death. vitro vivo investigations show that LA@CTx efficiently eliminate primary lesions provoke apoptosis cells dual-modality activation photodynamic treatments facilitated single NIR irradiation. study presents an innovative method therapy clinical treatment keloids.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 25, 2024
Hepatocellular carcinoma (HCC) is a highly malignant tumor that resistant to chemotherapy and immunotherapy. Icaritin (ICT), traditional Chinese medicine, has been reported as an immunoregulatory agent for treating advanced unresectable HCC. ICT induces mitophagy cause immunogenic cell death (ICD); however, the poor bioavailability of limits its therapeutic efficacy clinical use. Therefore, this study aimed assess effect using poly(2-(
Language: Английский
Citations
3
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 57778 - 57791
Published: Oct. 14, 2024
Given the variability in wounds based on underlying causes, personalized medicine and tailored care for patients with are required to ensure optimal therapeutic outcomes. With emergence of high-precision high-efficiency photocuring 3D printing technology, there is potential its use customizing precise shapes that can match complex wound sites, thereby providing better treatment infections. In this work, porphyrinic metal–organic framework (MOF) crystals, serving as functional filler, were incorporated into gelatin methacrylate (GelMA) a photocurable composite resin investigate capabilities producing customizable dressings through vat photopolymerization printing. The embedded MOF crystals allow control process due photon competition photoinitiator, enabling structures. addition, these impart photothermal photodynamic printed object. antibacterial assay confirms potent bactericidal properties GelMA/MOF hydrogels. hydrogel highest content exhibited over 99.99% efficiency against both Gram-positive Staphylococcus aureus Gram-negative Escherichia coli after 30 min light exposure (∼30 mW/cm2, λ ≥ 420 nm). Simultaneously, hemolysis cytotoxicity evaluations validated their excellent biocompatibility. findings presented here introduce strategy integrating photosensitive fabricate size-adjustable photothermal/photodynamic monoliths patches, opening perspectives toward management.
Language: Английский
Citations
2
Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112341 - 112341
Published: Dec. 1, 2024
Language: Английский
Citations
0