Bioinspired 3D‐Printed NIR‐Responsive MXene‐Based Multifunctional Eutectogel Microneedles for Personalized Infected Wound Healing DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Infected wound healing remains a significant clinical challenge, demanding innovative therapeutic strategies to simultaneously address bacterial elimination, tissue regeneration, and controlled drug delivery. Inspired by the hierarchical structure of crocodile teeth, bioinspired, 3D‐printed microneedle patch integrating Mxene nanosheets polymerizable deep eutectic solvent (PDES) composed vinyl pyrrolidone (VP), itaconic acid (IA), N‐isopropyl acrylamide (NIPAM) is developed. The resulting MXene‐based eutectogel (MF‐MXene@MN) combines photothermal responsiveness, antioxidant activity, temperature‐triggered release for conversion reactive oxygen species (ROS) scavenging. gradient‐height design inspired teeth enhances adhesion, while DLP 3D printing enables personalized dressing geometries with <50 µm resolution. In vitro in vivo studies demonstrated 94.88% closure rate within 10 days, 3.2‐fold increased angiogenesis, 68% reduced viability ( S. aureus : 32.59%; E. coli 48.17% under NIR), pH‐/temperature‐responsive mangiferin (88.3% cumulative via 5 NIR cycles). These synergistic functions promote healing, offering superior antibacterial ability, regeneration promotion, control compared traditional dressings systems. This multifunctional platform integrates bioinspired design, stimuli‐responsive materials, additive manufacturing, providing transformative solution precision management.

Language: Английский

A Metal-Based Heterojunction with Releasable Multiple Cations and Reactive Oxygen for Eradication of Multidrug-Resistant Bacteria DOI

Shao-Bo Guo,

Rong Hu, Yanming Qiao

et al.

Published: Jan. 1, 2025

Spherical heterojunction nanocomposite materials are utilized to treat wound infections caused by drug-resistant bacteria synergistically generating reactive oxygen species (ROS) and multiple cations (multiple inorganic or organic ions with positive points). However, there is an ongoing debate on the relative contributions of ROS towards antibacterial activity. With aim investigating activity, this study synthesized CuFe2O4/Cu@PEI/Ag (ZPA) nanocomposites release abundant •O2-, •OH, Fe3+, Cu2+, Ag+, polyethyleneimine (PEI). The results revealed that after 25 min, at a concentration 40.8 μg/mL, material exhibited inhibition rate over 99.99% against Staphylococcus aureus (S. aureus) methicillin-resistant S. (T- aureus). This activity could be attributed (Fe3+, Ag+ PEI) in following order: > •O2- •OH single cation. potential mechanism involved synergy mechanisms: Leakage cytoplasmic content due damage bacterial cell wall alteration secondary structure bound via electrostatic attraction. By healing T - aureus-induced infection completely eliminating burden 11 days ZPA also effectively polarized M1 type macrophages M2 vivo. Thus, findings elucidate combined effect free radicals properties composite materials. indicate holds clinical for treating infections.

Language: Английский

Citations

0
Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria DOI
Ling‐Min Pei, Xiaolin Yu, Xiaoyu Shan

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 29, 2025

The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Photodynamic transition metal complexes leveraging unique properties metals enhance aPDT activity are next-generation PS. review provides an overview metal-based PS Based on structures, these metal-PS could be mainly classified as metal-tetrapyrrole derivatives, ruthenium complexes, iridium and zinc complexes. based other such silver, cobalt, rhenium also presented. Finally, we summarize advantages shortcomings metal- PS, conclude some critical aspects impacting their performances give perspective future development.

Language: Английский

Citations

0
Crystal structure of 5′-(9-phenyl-9H-carbazol-3-yl)-[2,2′-bithiophene]-5-carbaldehyde, C27H17NOS2 DOI Creative Commons

Wen-Ze Zhao,

F.‐L. LU

Zeitschrift für Kristallographie - New Crystal Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract C 27 H 17 NOS 2 , monoclinic, P 1 / c (no. 14), a = 17.5582(11) Å, b 12.4355(8) 10.0535(5) β 103.391(2)°, V 2135.5 Å 3 Z 4, R gt ( F ) 0.0555, w ref 0.1093, T 273 K.

Language: Английский

Citations

0
Preparation, characterization, and antibacterial activity of Moringa oleifera‑silver nanoparticles-kaolinite nanocomposite DOI
Mustapha Isah, Nik Ahmad Nizam Nik Malek, Hendra Susanto

et al.

Applied Clay Science, Journal Year: 2025, Volume and Issue: 269, P. 107761 - 107761

Published: Feb. 21, 2025

Language: Английский

Citations

0
Cationic AIEgens with large rigid π-planes: Specific bacterial imaging and treatment of drug-resistant bacterial infections DOI

Senlin Peng,

Zhou Xu,

Qian Wang

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108412 - 108412

Published: March 1, 2025

Language: Английский

Citations

0
Amphiphilic Photosensitizer Based on Benzothioxanthene: Exploring Aggregation-Induced Enhancement of Reactive Oxygen Species Generation DOI
Yujie Feng, Yahui Liu, Andong Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

The application of photosensitizers has long been hindered by complex synthesis routes and poor water solubility. In this study, we report novel benzothioxene-based with significant improvements in both solubility photodynamic efficiency. Among them, the amphiphilic molecule QA-BTXI stands out, offering exceptional pronounced aggregation-induced enhancement reactive oxygen species generation. At a low concentration 25 μM, exhibits potent antibacterial activity against Escherichia coli Staphylococcus aureus. Additionally, is synthesized cost-effective manner 82% yield straightforward purification process. These findings present promising approach to developing next-generation broad potential for large-scale production practical applications.

Language: Английский

Citations

0
Crystal structure of (Z)-2-(5-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid, C18H16N2O3S2 DOI Creative Commons
Yi Li,

Tan Bo

Zeitschrift für Kristallographie - New Crystal Structures, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract C 18 H 16 N 2 O 3 S , Monoclinic, P 1 (no. 4), a = 12.3018(15) Å, b 5.8113(6) c 12.7380(12) β 107.735(4) ∘ V 867.36(16) Å Z 2, R gt ( F ) 0.0491, w ref 0.1055 T 273.15 K. The molecular structure is shown in the figure. Table contains crystallographic data. list of atoms including atomic coordinates and displacement parameters can be found cif-file attached to this article.

Language: Английский

Citations

0
Bioinspired 3D‐Printed NIR‐Responsive MXene‐Based Multifunctional Eutectogel Microneedles for Personalized Infected Wound Healing DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Infected wound healing remains a significant clinical challenge, demanding innovative therapeutic strategies to simultaneously address bacterial elimination, tissue regeneration, and controlled drug delivery. Inspired by the hierarchical structure of crocodile teeth, bioinspired, 3D‐printed microneedle patch integrating Mxene nanosheets polymerizable deep eutectic solvent (PDES) composed vinyl pyrrolidone (VP), itaconic acid (IA), N‐isopropyl acrylamide (NIPAM) is developed. The resulting MXene‐based eutectogel (MF‐MXene@MN) combines photothermal responsiveness, antioxidant activity, temperature‐triggered release for conversion reactive oxygen species (ROS) scavenging. gradient‐height design inspired teeth enhances adhesion, while DLP 3D printing enables personalized dressing geometries with <50 µm resolution. In vitro in vivo studies demonstrated 94.88% closure rate within 10 days, 3.2‐fold increased angiogenesis, 68% reduced viability ( S. aureus : 32.59%; E. coli 48.17% under NIR), pH‐/temperature‐responsive mangiferin (88.3% cumulative via 5 NIR cycles). These synergistic functions promote healing, offering superior antibacterial ability, regeneration promotion, control compared traditional dressings systems. This multifunctional platform integrates bioinspired design, stimuli‐responsive materials, additive manufacturing, providing transformative solution precision management.

Language: Английский

Citations

0