Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma DOI Creative Commons
Amal Babu,

Padmanaban Sathiyamoorthy,

Sahil Chahal

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% liver cancers, poses a significant health burden. effectiveness traditional carcinoma treatments such as surgical resection, radiotherapy, chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) R848 (resiquimod; TLR7/8 agonist) (PIR NPs). Characterization confirmed size loading capacity PIR NPs, controlled release therefrom upon NIR irradiation, thereby establishing potential versatile tool. NPs were readily taken up by Hepa 1-6 cells in vitro targeting asialoglycoprotein receptors present on its cellular surface. In vivo experiments combining photothermal therapy immunotherapy, following local near-infrared accumulated tumor sites induced immunogenic cell death activated tumor-specific T-cell immune response, thus highlighting their potent antitumor efficacy. combined efficacy immunotherapy presents promising avenue addressing shortcomings interventions. This study contributes valuable insights into development more effective targeted approaches treatment.

Language: Английский

Synthetic circRNA therapeutics: innovations, strategies, and future horizons DOI Creative Commons

Jingsheng Cai,

Zonghao Qiu,

William C. Cho

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Nov. 1, 2024

Abstract Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID‐19 vaccines has underscored the transformative potential in RNA therapeutics. Within family, there is another unique type known circRNA. This single‐stranded closed‐loop offers advantages over mRNA, including enhanced stability prolonged protein expression, which may significantly impact therapeutic strategies. Furthermore, circRNA plays pivotal role pathogenesis such cancers, autoimmune disorders, cardiovascular making it promising clinical intervention target. Despite these benefits, application settings remains underexplored. review provides comprehensive overview current state synthetic therapeutics, focusing on its synthesis, optimization, delivery, diverse applications. It also addresses challenges impeding advancement from bench to bedside. By summarizing aspects, aims equip researchers insights into ongoing developments future directions Highlighting both progress existing gaps research, this valuable perspectives advancing field guiding investigations.

Language: Английский

Citations

10
Revolutionizing cancer therapies with organic photovoltaic non-fullerene acceptors: A deep dive into molecular engineering for advanced phototheranostics DOI
Yaojun Li, Yun Li, Shenglong Liao

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110832 - 110832

Published: Jan. 1, 2025

Language: Английский

Citations

0
Biomimetic Hybrid Membrane-Cloaked Nanoparticles Assisted with Laser Irradiation for Synergistic Photothermal Immunotherapy of Fibrosarcoma DOI

Yuan Ma,

Zhao Wang,

Xiaogang Xia

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

Citations

0
Macrophage-Membrane-Engineered NIR II Biomimetic Nanomaterials for Enhanced Synergistic Chemo-Photothermal Immunotherapy in Cancer Treatment DOI
Bo Yao,

Jingpei Zhang,

Zhenghui Chen

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114759 - 114759

Published: May 9, 2025

Language: Английский

Citations

0
Blood Cell Membrane-Coated Nanomaterials as a Versatile Biomimetic Nanoplatform for Antitumor Applications DOI Creative Commons
H. Z. Shen,

Yongliang Ouyang,

Liang Zhang

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(21), P. 1757 - 1757

Published: Oct. 31, 2024

The application of nanomaterials in tumor therapy is increasingly widespread, offering more possibilities for enhanced therapy. However, the unclear biological distribution and metabolism may lead to immune rejection or inflammatory reactions, posing numerous challenges their clinical translation. rich diversity multifaceted functions blood cells offer promising avenues enhancing nanoparticles cancer Blood cell membranes, being made naturally found components body, exhibit significant biocompatibility, which can reduce body’s response, extend drug’s residence time bloodstream, enhance its bioavailability. Integrating membranes with enhances by improving targeted delivery, prolonging circulation time, evading responses. This review summarizes recent advancements membrane-coated antitumor therapy, a particular focus on use photodynamic photothermal treatments. Additionally, it explores potential synergistic effects when combined other therapeutic modalities.

Language: Английский

Citations

2
A metal-quercetin-histidine co-coordinated nanoparticle enhances cancer photothermal therapy via reshaping immunosuppressive tumor microenvironment DOI
Shaobo Wang,

Shuncheng Yao,

Quanhong Hu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156027 - 156027

Published: Sept. 20, 2024

Language: Английский

Citations

1
Photothermal therapy and cell imaging tracking of porous silicon nanoparticle by magnesiothermic reduction and surface modification DOI
Vy Anh Tran, Sang−Wha Lee, Thi Thu Trinh Phan

et al.

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102272 - 102272

Published: Aug. 28, 2024

Language: Английский

Citations

0
Biomimetic nanoparticles with red blood cell membranes for enhanced photothermal and immunotherapy for tumors DOI Creative Commons

Liquan Hong,

Jingtao Ye,

Yang Li

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(45), P. 32818 - 32826

Published: Jan. 1, 2024

The alarming escalation in cancer incidence and mortality has thrust into spotlight the quest for groundbreaking therapeutic strategies. Our research delves potential of RDIR780, a novel class biomimetic nanoparticles cloaked red blood cell membranes, to significantly enhance their

Language: Английский

Citations

0
Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma DOI Creative Commons
Amal Babu,

Padmanaban Sathiyamoorthy,

Sahil Chahal

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

The substantial mortality and morbidity of hepatocellular carcinoma, representing 90% liver cancers, poses a significant health burden. effectiveness traditional carcinoma treatments such as surgical resection, radiotherapy, chemotherapy is limited, underscoring the need for innovative therapeutic strategies. To this end, we synthesized phthalyl-pullulan nanoparticles encapsulating IR780 (an NIR-responsive heptamethine cyanine dye) R848 (resiquimod; TLR7/8 agonist) (PIR NPs). Characterization confirmed size loading capacity PIR NPs, controlled release therefrom upon NIR irradiation, thereby establishing potential versatile tool. NPs were readily taken up by Hepa 1-6 cells in vitro targeting asialoglycoprotein receptors present on its cellular surface. In vivo experiments combining photothermal therapy immunotherapy, following local near-infrared accumulated tumor sites induced immunogenic cell death activated tumor-specific T-cell immune response, thus highlighting their potent antitumor efficacy. combined efficacy immunotherapy presents promising avenue addressing shortcomings interventions. This study contributes valuable insights into development more effective targeted approaches treatment.

Language: Английский

Citations

0