Low Loading of Collagen in Electrospun Polyester Nerve Conduits for Repairing Segmental Nerve Defect: An Experimental Study Using the Tibial Nerve in Rats with Multiple Measurements DOI Creative Commons
Kanit Sananpanich,

Kairop Wiwattanapanich,

Donraporn Daranarong

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

The present study provides in vivo trials of electrospun poly(l-lactide-co-ε-caprolactone), PLCL, copolymer 67:33 mol %, and PLCL blend with a low loading collagen (0.5% w/v), PLCL-Col, as connecting porous biodegradable nerve conduit to repair 7 mm long segmentary tibial lesions rats compared the standard autograft technique. scaffolds reveal matrix fibers mean diameter 476 ± 60 nm an average pore size 253 5 nm. Blending results comparatively denser 417 42 244 3 For testing, total 30 male Wistar were divided into groups 10 each group was subjected different procedure for evaluation regeneration after reconstruction. Evaluation terms functional index (TFI), conduction velocity (NCV), gastrocnemius muscle weight (%GMW), histomorphometric study. After 12 weeks implantation, there evidence across gap from histomorphologic All parameters observed every animal groups. Our clearly showed that are reinnervation return function all groups, similarly group. PLCL-Col better than autograft, which suggested conduits may serve scaffold peripheral regeneration.

Language: Английский

Bifunctional cobalt ferrite/reduced graphene oxide heterojunction enhances the antibacterial and osteogenic activities of scaffold DOI
Cijun Shuai, Chong Lin, Xiuwen Gao

et al.

Applied Surface Science, Journal Year: 2025, Volume and Issue: unknown, P. 162942 - 162942

Published: March 1, 2025

Language: Английский

Citations

0

Piezoelectric Biomaterials for Use in Bone Tissue Engineering—A Narrative Review DOI Open Access
Sandeep Choudhury, Debaprasad Das, Sandipan Roy

et al.

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2025, Volume and Issue: 113(4)

Published: March 17, 2025

ABSTRACT To examine natural bone's bioelectrical traits, notably its piezoelectricity, and to look into how these characteristics influence bone growth repair. In the context of exploring potential piezoelectric biomaterials, such as biopolymers bio‐ceramics, towards orthopedic regeneration applications, research seeks evaluate significance piezoelectricity‐driven osteogenesis. The paper reviews recent on electrical dielectric properties, surface polarization/electrical stimulation effects interacting with cell activity effectiveness biomaterials support tissues' regenerative process. study includes a number materials, collagen, polyvinylidene fluoride (PVDF) barium titanate. applications organic polymers, polymers are particularly highlighted. Piezoelectric being shown in studies enhance cellular metabolism vitro well promote tissues vivo, especially when paired electric field or interface polarization. bio‐ceramics like magnesium silicate titanate, collagen PVDF, have possibilities for applications. However, there several challenges regarding manufacturing specific compositions having desired properties. This review highlighted special emphasis bioceramics. Therefore, types materials huge because they can mimic properties allow better advances tissue engineering medicine. date, little is known about their mechanism action, modifications needed improve efficacy clinical uptake.

Language: Английский

Citations

0

Low Loading of Collagen in Electrospun Polyester Nerve Conduits for Repairing Segmental Nerve Defect: An Experimental Study Using the Tibial Nerve in Rats with Multiple Measurements DOI Creative Commons
Kanit Sananpanich,

Kairop Wiwattanapanich,

Donraporn Daranarong

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

The present study provides in vivo trials of electrospun poly(l-lactide-co-ε-caprolactone), PLCL, copolymer 67:33 mol %, and PLCL blend with a low loading collagen (0.5% w/v), PLCL-Col, as connecting porous biodegradable nerve conduit to repair 7 mm long segmentary tibial lesions rats compared the standard autograft technique. scaffolds reveal matrix fibers mean diameter 476 ± 60 nm an average pore size 253 5 nm. Blending results comparatively denser 417 42 244 3 For testing, total 30 male Wistar were divided into groups 10 each group was subjected different procedure for evaluation regeneration after reconstruction. Evaluation terms functional index (TFI), conduction velocity (NCV), gastrocnemius muscle weight (%GMW), histomorphometric study. After 12 weeks implantation, there evidence across gap from histomorphologic All parameters observed every animal groups. Our clearly showed that are reinnervation return function all groups, similarly group. PLCL-Col better than autograft, which suggested conduits may serve scaffold peripheral regeneration.

Language: Английский

Citations

0