Hemocompatible nucleosome-inspired heparin-mimicking hydrogel microspheres for safe and efficient extracorporeal removal of circulating histones in critically ill patients

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The tailored RCHMs can adsorb circulating histones through electrostatic interactions with excellent hemocompatibility and significantly attenuate histone-mediated thrombocytopenia, platelet aggregation, endothelial cell death.

Language: Английский

Theoretical Calculations in Separation Science for Analytical Chemistry: Applications and Insights

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Separation and enrichment are critical steps in analytical detection, necessitating advanced materials with high selectivity adsorption capacity for target compounds. In order to improve separation efficiency selectivity, computational simulation could elucidate interaction mechanisms analyze potential adsorption/desorption processes, providing a theoretical foundation the optimization design of materials. Recently, has become an indispensable crucial mean science chemistry. Using various software, researchers investigate structures, properties, performance at multiple levels scales. this review, we summarize applications simulations field science, focusing on polar molecules, geometric isomers, enantiomer compounds, post‐translationally modified peptides. These calculation methods include quantum chemistry, molecular docking, dynamics simulations, high‐throughput screening, machine learning. Finally, discuss current challenges breakthroughs simulation, aiming offer valuable insights dedicated material development, applications.

Language: Английский

Deciphering endogenous SUMO-1 landscape: a novel combinatorial peptide enrichment strategy for global profiling and disease association

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Using a “dual-hook fishing” approach, this method selectively captures two C-terminal regions of SUMO-1 remnants, enabling an unprecedented and comprehensive landscape modifications across species.

Language: Английский