Polymorphic Supramolecular Therapeutic Platforms with Precise Dye/Drug Ratio to Perform Synergistic Chemo‐Photo Anti‐Tumor Therapy and Long‐Term Immune Protection DOI Open Access

Jinhao Yan,

Haoqi Wang,

Xueqin Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Malignant tumor has become one of the hellish killers threatening health people around world, its diagnosis and treatment concerns public. However, optimal therapeutic dose, undesired side‐effect, long‐term immune activation were key bottleneck problems in treatment. Herein, different batches supramolecular platforms, including vesicles, spherical nanoparticles, cylindrical nanorods, with precise ratios dye to drug (1:2) multiple stimulus responsiveness constructed by host‐guest complexation between cyanine‐camptothecin conjugates (IR780‐CPT2) β‐cyclodextrin (β‐CD) pendent hydrophilic copolymers. The reduction responsiveness, near‐infrared photothermal conversion singlet oxygen ( 1 O 2 ) generation performances endowed these platforms excellent cancer cells killing effect both vitro cellular experiments vivo mice models. More importantly, without affecting weight mice, maturation dendritic cells, proliferation T up‐regulation high mobility group protein B1, immunosuppressive regulatory detected after employing a synergistic chemo‐photo therapy, demonstrating body's was successfully activated. Thus, during primary tumor, distal also inhibited. We believe this work could provide distinctive way fabricate theranostic morphologies improve antitumor antimetastasis capabilities.

Language: Английский

Self-Assembled Ce6-Peptide Nanoparticles Enhance NO Production and Photodynamic Therapy against Bacterial Infections DOI

Miaozhong Shen,

Jing Yan,

Weiyu Xing

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

The alarming rise of antibiotic resistance necessitates the development innovative antibacterial strategies. Photodynamic therapy (PDT) has emerged as a promising alternative, but its efficacy is often hindered by poor photosensitizer solubility and potential biotoxicity. To overcome these limitations, we designed peptide-photosensitizer conjugate, chlorin e6-RFSSFR (Ce6-RFSSFR), which self-assembles into nanoparticles with improved photodynamic properties. This conjugate leverages arginine residues nitric oxide (NO) donors upon light activation, facilitating localized NO production amplifying effects PDT. Our in vitro vivo evaluations demonstrate superior therapeutic Ce6-RFSSFR over conventional Ce6, enhanced efficacy, remarkable wound healing promotion, anti-inflammatory These findings position candidate for clinical applications bacterial infection treatment tissue regeneration, offering valuable tool fight against antimicrobial resistance.

Language: Английский

Citations

0
Twin-Tail Tadpole-Shaped Ce6-Peptide Conjugate for Enhanced Photodynamic Cancer Therapy DOI
Mengmeng Jiang,

Shaowen Wu,

Hongxia Zhang

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Despite its therapeutic potential, photodynamic therapy faces several key limitations in clinical applications, including poor drug delivery and insufficient tumor selectivity. We engineered RFYFYR-Ce6-RFYFYR (R-Ce6-R), a twin-tail peptide–photosensitizer conjugate that self-assembles into nanostructures for improved cancer treatment. By incorporating arginine-rich peptide sequences, this design not only enhances cellular internalization but also promotes peroxynitrite (ONOO–) formation, amplifying the effect. Our studies revealed R-Ce6-R achieves 33-fold higher potency than unmodified Ce6, with an IC50 of 0.18 μM. The demonstrated selective accumulation tissue, robust ROS generation, complete regression animal models while maintaining favorable safety profile. These results establish as innovative approach advancing

Language: Английский

Citations

0
Inherently Anti-Metastatic Peptide Hydrogels for Sonodynamic-Amplified Ferroptosis in Cancer Therapy DOI Creative Commons
Hongxia Zhang, Yamei Wang, Mengmeng Jiang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101688 - 101688

Published: March 1, 2025

Language: Английский

Citations

0
Polymorphic Supramolecular Therapeutic Platforms with Precise Dye/Drug Ratio to Perform Synergistic Chemo‐Photo Anti‐Tumor Therapy and Long‐Term Immune Protection DOI Open Access

Jinhao Yan,

Haoqi Wang,

Xueqin Zhao

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Malignant tumor has become one of the hellish killers threatening health people around world, its diagnosis and treatment concerns public. However, optimal therapeutic dose, undesired side‐effect, long‐term immune activation were key bottleneck problems in treatment. Herein, different batches supramolecular platforms, including vesicles, spherical nanoparticles, cylindrical nanorods, with precise ratios dye to drug (1:2) multiple stimulus responsiveness constructed by host‐guest complexation between cyanine‐camptothecin conjugates (IR780‐CPT2) β‐cyclodextrin (β‐CD) pendent hydrophilic copolymers. The reduction responsiveness, near‐infrared photothermal conversion singlet oxygen ( 1 O 2 ) generation performances endowed these platforms excellent cancer cells killing effect both vitro cellular experiments vivo mice models. More importantly, without affecting weight mice, maturation dendritic cells, proliferation T up‐regulation high mobility group protein B1, immunosuppressive regulatory detected after employing a synergistic chemo‐photo therapy, demonstrating body's was successfully activated. Thus, during primary tumor, distal also inhibited. We believe this work could provide distinctive way fabricate theranostic morphologies improve antitumor antimetastasis capabilities.

Language: Английский

Citations

0