Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment

Materials Today Bio, Journal Year: 2025, Volume and Issue: 30, P. 101441 - 101441

Published: Jan. 1, 2025

The therapeutic effect of immune checkpoint inhibitors (ICIs) in triple-negative breast cancer (TNBC) is unsatisfactory. "cold" microenvironment caused by tumor-associated fibroblasts (TAFs) has an adverse on the antitumor response. Therefore, this study, mixed cell membrane-coated porous magnetic nanoparticles (PMNPs) were constructed to deliver salvianolic acid B (SAB) induce response, facilitating transition from a "hot" tumor and ultimately enhancing efficacy inhibitors. PMNP-SAB, which based coating red blood membrane TAF (named PMNP-SAB@RTM), can simultaneously achieve dual effects "immune escape" "homologous targeting". Under influence external field (MF), SAB be targeted concentrated at site. released tumors effectively inhibit production extracellular matrix (ECM) TAFs, promote T-cell infiltration, responses. Ultimately, combination PMNP-SAB@RTM BMS-1 (PD-1/PD-L1 inhibitor 1) inhibited growth. Finally, study presents precise effective new strategy for TNBC immunotherapy basis differentiation microenvironments.

Language: Английский

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The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 409 - 409

Published: March 25, 2025

Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.

Language: Английский

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Differential Effects of Rutin and Its Aglycone Quercetin on Cytotoxicity and Chemosensitization of HCT 116 Colon Cancer Cells to Anticancer Drugs 5-Fluorouracil and Doxorubicin

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 527 - 527

Published: May 9, 2025

Background: Rutin and quercetin are natural flavonoids with a variety of beneficial health effects, including anticancer activity. In the present study, we compared cytotoxicity chemosensitization human colon cancer HCT116 cells to drugs 5-fluorouracil (5-FU) doxorubicin (DOX) by both compounds. Methods: The 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) test was used determine cell viability. Western blot immunofluorescence techniques were employed in detection expression proteins involved oxidative stress, apoptosis, autophagy. Results: Quercetin treatment resulted reduced viability rutin at same dose, suggesting greater than against cells. also better chemosensitizer DOX rutin, further reducing However, 5-FU quercetin. All treatments induced inducing intrinsic extrinsic apoptotic death. Autophagy all played pro-survival role, exception treatment. Different regimens specifically modulated signaling pathways regulation Conclusions: results current study suggest that quercetin, although structural analogs, act as specific modulators cells, differentially affecting drugs, based on presence free hydroxyl group C-3 position flavonoid backbone or rutinose rutin.

Language: Английский

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Application of bifidobacterium in tumor therapy

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 15, 2025

Current clinical cancer treatments primarily rely on surgery, chemotherapy, radiotherapy, and immunotherapy; however, each approach has inherent limitations. In recent years, nanomaterials have gained significant attention in oncology due to their advantages precise drug delivery, enhanced targeting, improved therapeutic efficacy. Nevertheless, application remains limited by challenges such as complex synthesis, high costs, low delivery efficiency, poor biodegradability. Bifidobacterium (BBM), a clinically used probiotic, demonstrated unique tumor-targeting potential its obligate anaerobic nature, allowing it selectively colonize, proliferate, expand within the hypoxic tumor microenvironment. Recent advancements synthetic biology bacterial engineering enabled modification of microrobot for molecular imaging, or gene other functions. Compared nanomaterials, Bifidobacterium-based therapy holds promise overcoming certain limitations while potentially enhancing comprehensive treatment modulating microenvironment boosting host immune responses. This review summarizes latest progress Bifidobacterium-mediated imaging therapy, explores mechanisms action, strategies, applications, discusses future directions optimizing functional design improve efficacy safety.

Language: Английский

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Combination Using Magnetic Iron Oxide Nanoparticles and Magnetic Field for Cancer Therapy

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Iron oxide nanoparticles (MNPs) demonstrate notable benefits in magnetic induction, attributed to their distinctive physical and chemical attributes. Emerging cancer treatment utilizing fields have also gathered increasing attention the biomedical field. However, defects of difficult dispersion poor biocompatibility MNPs seriously hinder application. In order overcome its inherent maximize therapeutic potential MNPs, various functionalized been developed, numerous combined methods based on widely studied. this review, we compare analyze common with different sizes, shapes, functional modifications. Additionally, introduced mechanisms strategies, such as magnetically controlled targeting, hyperthermia, magneto‐mechanical effect, which unique induction capabilities MNPs. Finally, main challenges smart nanomaterials were discussed. This review seeks offer a thorough overview biomedicine new sight for application tumor treatment.

Language: Английский

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