Multifunctional nanomaterials composed entirely of active pharmaceutical ingredients for synergistically enhanced antitumor and antibacterial effects DOI Creative Commons

Qi An,

Dongmei Wang, Liang Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 21, 2024

Introduction Multifunctional nanomaterials are emerging as promising tools for treating both cancer and bacterial infections. However, integrating dual therapeutic capabilities into a single system remains challenging. This study presents multifunctional nanoparticles (ECI-NPs) based on Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), Indocyanine Green (ICG) combined treatment. Methods ECI-NPs were synthesized via oxidative coupling of EGCG, CUR, ICG. The characterized stability, size, drug loading, release profiles. Cellular uptake, phototoxicity in melanoma cells, antibacterial activity against Escherichia coli Staphylococcus aureus also evaluated. Results demonstrated optimal high controlled release. studies showed increased uptake greater cells compared to free drugs. exhibited enhanced anticancer effects strong activity, outperforming the individual components. Discussion polyphenol-based offer synergistic effects, overcoming limitations drugs terms solubility efficacy. dual-function platform shows potential broader biomedical applications, addressing challenges Further research will focus vivo clinical translation.

Language: Английский

Responsive hydrogel modulator with self-regulated polyphenol release for accelerating diabetic wound healing via precise immunoregulation DOI
Yunfei Tan, Лей Ма, Yixuan Wu

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Responsive hydrogels were capable of achieving the spatiotemporally controlled release polyphenol that relieved severe oxidative stress and modulated macrophage polarization, thus accelerating diabetic wound healing.

Language: Английский

Citations

1
Photothermal effect-enhanced antibacterial hydrogel with anti-inflammation and anti-oxidation properties: Macrophage polarization promotes infected wound healing DOI
Yixuan Wu, Лей Ма, Yunfei Tan

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161400 - 161400

Published: March 1, 2025

Language: Английский

Citations

1
Pickering stabilization of double emulsions: Basic concepts, rationale, preparation, potential applications, challenges, and future perspectives DOI Creative Commons
Anuj Niroula, Albert T. Poortinga, Akmal Nazir

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 343, P. 103531 - 103531

Published: May 1, 2025

Language: Английский

Citations

1
Baicalein based nano-delivery system restores mitochondrial homeostasis through PPAR signaling pathway to promote wound healing in diabetes DOI Creative Commons

Danlei Qin,

Weiting Hu,

Yanqin Guo

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 19, 2025

Wound healing in diabetes is a substantial clinical challenge due to the hyperglycemic microenvironment, high pH, bacterial infection, persistent inflammation, and impaired cellular functions, attributed mitochondrial dysfunction. Here, we have developed an injectable photo-crosslinking nanocomposite hydrogel (BA/GOx@ZIF-8@GelMA, BGZ@GelMA) with baicalein (BA) glucose oxidase (GOx) loaded Zinc metal-organic framework (ZIF-8) based on methacrylated gelatin (GelMA) accelerate diabetic infected wound by regulating subcellular functions. The combination of ZIF-8 BA gives excellent antibacterial properties. A blood sugar environment triggers release GOx BGZ@GelMA, reducing local producing hydrogen peroxide (H2O2), releasing ions (Zn2+). This process provides suitable microenvironment for healing. Zn2+ can significantly inhibit proliferation Staphylococcus aureus (S.aureus) Escherichia coli (E.coli). released clear ROS cells mitochondria, restore function stability, make fundamentally improve cell damage induced hyperglycemia, ultimately promote proliferation, migration angiogenesis. In general, our multifunctional new strategy at functional levels.

Language: Английский

Citations

1
3D-printed Multifunctional Bilayer Scaffold with Sustained Release of Apoptotic Extracellular Vesicles and Antibacterial Coacervates for Enhanced Wound Healing DOI
Linli Jiang, Jia Dong, Minwen Jiang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123196 - 123196

Published: Feb. 15, 2025

Language: Английский

Citations

0
Diblock Copolymer Nanoparticles Bearing Phenols: Potential Stimuli-Responsive Pickering Emulsifiers with Antioxidant and Antibacterial Activities DOI

Jiani Peng,

Yong Gao

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Construction of flaxseed polyphenol nanolipid emulsions as edible coatings and their application in shelf life extension of spiced beef DOI Creative Commons
Yan Ma, Nan Wang, Xiaoyong Liu

et al.

Food Chemistry X, Journal Year: 2025, Volume and Issue: 27, P. 102502 - 102502

Published: April 1, 2025

Flaxseed polyphenols exhibited antibacterial and antioxidant properties; however, their poor solubility stability limited application in food products. Incorporation into nano-emulsions improved dissolution encapsulation. This study evaluated the of flaxseed polyphenol nano-emulsions, formulated with chitosan, lactoferrin, glyceryl monocaprate, gum (FP-CTS-FG, FP-LF-FG,FP-GM-FG), over 28 days storage, heating at 60/80/100 °C, freeze-thaw cycles -20 °C. The initial zeta potentialof these three emulsions are all greater than 30 mV, particle sizes less 500 nm. Minimal changes size, potential, phase behavior, along reduced surface tension droplet aggregation, indicated good stability. When used as a coating for spiced beef, emulsion moisture loss, inhibited microbial growth, delayed lipid oxidation quality deterioration. Overall, our findings provided new insights avenues industry.

Language: Английский

Citations

0
Mg-doped bioactive glass and tea polyphenols incorporated Janus wound dressing for antibacterial and promoting tissue repair DOI
Xin Zhao, Jingjing Jiao,

Man Ao

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114796 - 114796

Published: May 1, 2025

Language: Английский

Citations

0
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications DOI Open Access
Kazuhiko Nakadate,

Nozomi Ito,

Kiyoharu Kawakami

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(11), P. 5206 - 5206

Published: May 28, 2025

Chronic inflammation is a key contributor to the development and progression of numerous chronic diseases, including cardiovascular type 2 diabetes, neurodegenerative disorders, cancer, obesity. As side effects conventional anti-inflammatory drugs pose challenges, plant-derived compounds have emerged as promising alternatives due their potent properties minimal adverse effects. This review explores molecular mechanisms by which these alleviate highlights potential role in disease prevention. Polyphenols (e.g., quercetin resveratrol), flavonoids luteolin apigenin), carotenoids β-carotene lycopene), other phytochemicals curcumin gingerol) modulate inflammatory pathways, such nuclear factor-κB mitogen-activated protein kinase, reduce oxidative stress, inhibit pro-inflammatory cytokines. Plant-derived interact with gut microbiota, enhancing Evidence from animal studies clinical trials has demonstrated efficacy reducing inflammation-related biomarkers improving health outcomes. However, challenges low bioavailability determination optimal dosage require further investigation. Advancing delivery technologies personalized nutrition strategies may help overcome barriers. emphasizes therapeutic preventing diseases underscores need for continued research translate findings into practical applications public health.

Language: Английский

Citations

0
Multifunctional nanomaterials composed entirely of active pharmaceutical ingredients for synergistically enhanced antitumor and antibacterial effects DOI Creative Commons

Qi An,

Dongmei Wang, Liang Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 21, 2024

Introduction Multifunctional nanomaterials are emerging as promising tools for treating both cancer and bacterial infections. However, integrating dual therapeutic capabilities into a single system remains challenging. This study presents multifunctional nanoparticles (ECI-NPs) based on Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), Indocyanine Green (ICG) combined treatment. Methods ECI-NPs were synthesized via oxidative coupling of EGCG, CUR, ICG. The characterized stability, size, drug loading, release profiles. Cellular uptake, phototoxicity in melanoma cells, antibacterial activity against Escherichia coli Staphylococcus aureus also evaluated. Results demonstrated optimal high controlled release. studies showed increased uptake greater cells compared to free drugs. exhibited enhanced anticancer effects strong activity, outperforming the individual components. Discussion polyphenol-based offer synergistic effects, overcoming limitations drugs terms solubility efficacy. dual-function platform shows potential broader biomedical applications, addressing challenges Further research will focus vivo clinical translation.

Language: Английский

Citations

2