Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

NIR II light-driven nanomotor synergistically enhances immunogenic cell death through photothermal and chemodynamic therapy for melanoma immunotherapy DOI
Xuan Hu, Ziyan Shen,

H. Hao

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 694, P. 137688 - 137688

Published: April 23, 2025

Language: Английский

Citations

0
Integration of Fe(III)-Chelated Polydopamine and Diallyl Trisulfide for Boosting Ferroptosis to Reverse Multidrug Resistance and Inducing Synergistic Tumor Nanotherapy DOI

Yiwang Zhao,

Shunyu Yao, Jing Huang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25580 - 25592

Published: Nov. 2, 2024

Multidrug resistance (MDR) has long been a fundamental obstacle in tumor chemotherapy. MDR is often associated with overexpression of an adenosine triphosphate (ATP)-binding cassette transporter resistant cancer cells, which highly ATP-dependent. Therefore, reversing by down-regulated ATP expression promising strategy. This study developed redox-regulating nanotherapeutic for boosting ferroptosis, MDR, and inducing synergistic therapy. Fe(III)-chelated polydopamine (Fe-PDA) the key to design such nanotherapeutic, laser irradiation can speed up electron transfer between Fe3+ Fe2+ production hydroxyl radical (•OH). Coating layer Fe-PDA on surface mesoporous silica (MSN)-encapsulated diallyl trisulfide (DATS), doxorubicin (DOX) was loaded Fe-PDA. Upon triggering, (DATS@MSN@Fe-PDA/DOX, DMFPD) produced photothermal (•OH) hydrogen sulfide (H2S) apoptotic cell death. The DATS depleted intracellular glutathione (GSH), together H2S boosted ferroptosis. Ferroptosis effectively caused mitochondrial dysfunction, thereby suppressing expression. interactive death chemotherapy sensitization were further demonstrated 4T1 tumor-bearing mouse model high level biosafety. provides strategy clinical theragnostics.

Language: Английский

Citations

1
Recent developments in photothermal therapy: a bibliometric and visual analysis DOI

Runying Guo,

Rongrong Zhang,

Yuqi Xin

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Dec. 8, 2024

Photothermal therapy (PTT) has recently garnered significant attention as a prominent noninvasive treatment modality for broad spectrum of diseases. Despite the increasing volume scholarly output over last 20 years, holistic synthesis that delineates worldwide research trajectories remains elusive. We undertook bibliometric analysis literature from 2004 to 2023, aiming delineate prevailing focal points and illuminate prospective avenues. Research articles on PTT were retrieved Web Science Core Collection. Using tools such CiteSpace, VOSviewer, Bibliometrix, we comprehensively analyzed visualized 11,184 published academic papers. China highest number publications. Journals related are primarily comprised interdisciplinary comprehensive journals. associated with focused its antitumor properties. Current areas in this domain include synergistic combination photodynamic therapy, immunological mechanisms enhance therapeutic efficacy, integrated use nanoenzyme catalysis, role antimicrobial applications. This provides an initial examination medical applications PTT, offering insights into global landscape, key interest, emerging trends, thereby serving valuable reference future studies field.

Language: Английский

Citations

0
Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Citations

0