ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(48), P. 65877 - 65889
Published: Nov. 22, 2024
Bacterial
infections
pose
significant
challenges
in
wound
healing
and
are
a
serious
threat
to
human
health.
Hydrogels
have
emerged
as
an
ideal
dressing
due
their
three-dimensional
network,
which
facilitates
exudate
absorption
maintains
moist
environment
conducive
healing.
Herein,
we
developed
integrated
hydrogels
composed
of
poly(thioctic
acid)
(PTA),
polydopamine
(PDA),
curcumin
(Cur).
The
formation
covalent
hydrogen
bonds
among
PTA,
PDA,
Cur
endowed
the
with
excellent
self-healing
bioadhesion
properties.
These
were
utilized
dressings
for
Staphylococcus
aureus-infected
wounds.
PDA–PTA–Cur
16
hydrogel
showed
best
overall
performance
stability,
bioadhesion,
antioxidant
activity,
antibacterial
effectiveness.
vivo
results
revealed
that
accelerated
infected
by
inhibiting
bacterial
growth,
alleviating
inflammation,
promoting
collagen
deposition,
inducing
angiogenesis.
This
multifunctional
not
only
enhances
but
also
presents
promising
strategy
combating
clinical
settings.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
Natural
remedies
are
gaining
attention
as
promising
approaches
to
alleviating
inflammation,
yet
their
full
potential
is
often
limited
by
challenges
such
poor
bioavailability
and
suboptimal
therapeutic
effects.
To
overcome
these
limitations,
we
have
developed
a
novel
nano-antioxidant
(EK)
based
on
epigallocatechin
gallate
(EGCG)
aimed
at
enhancing
the
oral
systemic
bioavailability,
well
anti-inflammatory
efficacy,
of
curcumin
(Cur)
in
conditions
acute
colon
kidney
inflammation.
EK
synthesized
using
straightforward
Mannich
reaction
between
EGCG
L-lysine
(K),
resulting
formation
oligomers.
These
oligomers
spontaneously
self-assemble
into
nanoparticles
with
spherical
morphology
an
average
diameter
approximately
160
nm.
In
vitro
studies
reveal
that
exhibit
remarkable
radical-scavenging
capabilities
effectively
regulate
redox
processes
within
macrophages,
key
component
body’s
inflammatory
response.
By
efficiently
encapsulating
nanoparticles,
create
Cur@EK,
formulation
demonstrates
synergistic
effect.
Specifically,
Cur@EK
significantly
reduces
levels
pro-inflammatory
cytokines
TNF-α
IL-6
while
increasing
cytokine
IL-10
lipopolysaccharide-stimulated
highlighting
its
potent
properties.
When
administered
either
orally
or
intravenously,
shows
superior
compared
free
exhibits
pronounced
effects
mouse
models
ulcerative
colitis
injury.
findings
suggest
platform
not
only
enhances
but
also
amplifies
impact,
offering
new
avenue
for
treatment
management
inflammation
both
contexts.
Particulate Science And Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 12
Published: Jan. 11, 2025
The
present
study
aimed
to
develop
enteric-coated
mucoadhesive
pellets
of
Tofacitinib
citrate
(TOF)
for
site-specific
delivery
in
the
treatment
ulcerative
colitis
(UC).
formulation
(B2)
was
selected
based
on
uniform
particle
size
distribution,
flow
properties,
and
drug
content.
Further,
it
showed
robust
mechanical
characteristics
minimized
friability.
FTIR
studies
revealed
purity
TOF
good
compatibility
with
excipients.
Meanwhile,
DSC
XRD
demonstrated
successful
confinement
reduced
crystalinity.
SEM
images
a
consistent,
crack-free
enteric
coating
pellets.
In-vitro
release
indicated
pH-sensitive
attaining
nearly
98%
at
pH
7.4
by
following
zero-order
kinetic
affirming
colon.
Bioadhesive
retention
colon
supported
mucoadhesion
tests,
which
over
90%
adherence.
In-vivo
activity
score
(CAS)
colon/body
weight
ratio
considerably
inflammation
rats
treated
B2
than
marketed
formulation.
Moreover,
reductions
IL-6
levels
were
corroborated
anti-inflammatory
response
repairment
mucosal
layer,
as
evidenced
histopathological
analysis.
At
outset,
developed
promising
strategy
delivering
effective
management
UC.
Biomacromolecules,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
Hemostasis
is
the
initial
step
in
wound
healing,
yet
significant
challenges,
such
as
massive
bleeding
and
infection,
often
arise.
In
this
study,
we
developed
amphiphilic
biodegradable
polyester-based
segmented
polyurethane
(SPU)
microspheres
modified
with
epigallocatechin
gallate
(EGCG)-Ag
nanoparticles
calcium-alginate
cross-linking
shell,
combining
blood
absorption
pro-coagulation
properties
of
Ca2+
negative
charge
EGCG
for
synergistic
hemostatic
effects
across
various
stages
coagulation
cascade.
The
vitro
clotting
time
SPU@EAg@CaAlg
microsphere
(328.7
s)
was
reduced
by
half
compared
to
SPU
(685.0
s).
exhibited
a
loss
three
rat
models.
Additionally,
EGCG-Ag
imparted
strong
antibacterial
anti-inflammatory
both
vivo.
vivo
infected
model
demonstrated
that
effectively
eliminated
bacteria
levels
pro-inflammatory
factors,
thereby
promoting
healing.
Thus,
present
promising
candidate
effective
applications.
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
17(9), P. 13676 - 13689
Published: Feb. 22, 2025
Crohn's
disease
(CD)
is
a
relapsing,
systemic
inflammatory
that
primarily
affects
the
gastrointestinal
tract
and
often
accompanied
by
extraintestinal
manifestations
associated
immune
disorders.
However,
current
pharmacological
treatments
for
CD
encounter
several
challenges,
such
as
lack
of
precise
drug
targeting
inadequate
retention
drugs
in
inflamed
colon,
along
with
low
bioavailability.
Herein,
we
utilized
oleic
acid
(OA)
solvent
to
enhance
bioavailability
solubility
emodin.
Simultaneously,
encapsulated
OA-emodin
(OAE)
into
hydrogel
microspheres
(HMs)
composed
hyaluronic
(HA)
calcium
alginate
(CA)
develop
colon-targeted
delivery
system
(HM@OAE)
therapy.
The
pH
responsiveness
CA
enabled
HM@OAE
bypass
stomach
specifically
target
where
it
released
OAE
following
oral
administration.
In
addition,
vitro
studies
demonstrated
significantly
reduced
secretion
proinflammatory
cytokines,
decreased
reactive
oxygen
species
levels,
restrained
ferroptosis
upregulating
GPX4
SLC7A11
expression
while
downregulating
ACSL4
expression.
Furthermore,
confirm
these
findings
live
organism,
an
vivo
study
was
conducted
using
dextran
sulfate
sodium-induced
colitis
mouse
model.
This
validated
therapeutic
efficacy
HM@OAE,
alleviating
colonic
inflammation
restoring
intestinal
epithelial
integrity.
These
results
suggest
promising
clinical
candidate
treatment.
