Cystine-Modified Lignin–Copper Coordination Nanocarriers Improve the Therapeutic Efficacy of Tyrosine Kinase Inhibition via Cuproptosis DOI

Shiyao Song,

Xingfeng Qiu,

Shaoqing Huang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

The clinical application of tyrosine kinase inhibitors (TKIs) is rapidly growing and has emerged as a cornerstone in the treatment both solid tumors hematologic malignancies. However, resistance to TKI targets disease progression remain inevitable. Nanocarrier-mediated delivery promising strategy overcome limitations application. We utilized facile modification lignin polyhydroxyl groups synthesize cystine-grafted lignin–copper coordinated nanoparticles for via Mannich reaction. materials exhibited stable, uniform morphology effectively encapsulated delivered variety inhibitors. Moreover, we optimized fabrication process found that material could release drug response pH GSH. These significantly enhanced therapeutic activity TKIs vitro vivo through cuproptosis while demonstrating good biosafety. propose novel targeted by combining with modified lignin. This approach not only offers new strategies but also provides insights inspiration use

Language: Английский

Cystine-Modified Lignin–Copper Coordination Nanocarriers Improve the Therapeutic Efficacy of Tyrosine Kinase Inhibition via Cuproptosis DOI

Shiyao Song,

Xingfeng Qiu,

Shaoqing Huang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

The clinical application of tyrosine kinase inhibitors (TKIs) is rapidly growing and has emerged as a cornerstone in the treatment both solid tumors hematologic malignancies. However, resistance to TKI targets disease progression remain inevitable. Nanocarrier-mediated delivery promising strategy overcome limitations application. We utilized facile modification lignin polyhydroxyl groups synthesize cystine-grafted lignin–copper coordinated nanoparticles for via Mannich reaction. materials exhibited stable, uniform morphology effectively encapsulated delivered variety inhibitors. Moreover, we optimized fabrication process found that material could release drug response pH GSH. These significantly enhanced therapeutic activity TKIs vitro vivo through cuproptosis while demonstrating good biosafety. propose novel targeted by combining with modified lignin. This approach not only offers new strategies but also provides insights inspiration use

Language: Английский

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