Spontaneously Photocatalytic Nanoplatform for Sensitive Diagnosis and Penetrated Therapy of Cancer DOI

Huairong Zhang,

Feng Lu, Haijun Yu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

In this study, a sensitive diagnosis and spontaneously photocatalytic therapy of cancer based on chemiluminescence (CL) nanozyme was studied. Briefly, carbon nitride-supported copper nanoparticles (CuCNs) loaded with luminol (CuCN-L) were utilized to develop microneedle patch (CuCN-L/MN). The CuCN-L probe could target overexpressed H2O2 in the TME actively emit CL achieve cell imaging for diagnosis. addition, 425 nm blue-violet photocatalyze CuCN reduce dioxide (CO2) monoxide (CO) gas (GT). Meanwhile, CuCN, acting as photosensitizer (PS), be activated by produce reactive oxygen species (ROS), which realized photodynamic (PDT). Furthermore, use degradable MN hyaluronic acid (HA) promotes painless local administration well deep GT PDT. This technology optical sensor-mediated anticancer treatment will have great potential provide new inspirations self-excited nanoplatform.

Language: Английский

Spontaneously Photocatalytic Nanoplatform for Sensitive Diagnosis and Penetrated Therapy of Cancer DOI

Huairong Zhang,

Feng Lu, Haijun Yu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

In this study, a sensitive diagnosis and spontaneously photocatalytic therapy of cancer based on chemiluminescence (CL) nanozyme was studied. Briefly, carbon nitride-supported copper nanoparticles (CuCNs) loaded with luminol (CuCN-L) were utilized to develop microneedle patch (CuCN-L/MN). The CuCN-L probe could target overexpressed H2O2 in the TME actively emit CL achieve cell imaging for diagnosis. addition, 425 nm blue-violet photocatalyze CuCN reduce dioxide (CO2) monoxide (CO) gas (GT). Meanwhile, CuCN, acting as photosensitizer (PS), be activated by produce reactive oxygen species (ROS), which realized photodynamic (PDT). Furthermore, use degradable MN hyaluronic acid (HA) promotes painless local administration well deep GT PDT. This technology optical sensor-mediated anticancer treatment will have great potential provide new inspirations self-excited nanoplatform.

Language: Английский

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