Transition from Procoagulation to Antiplatelet Effect: Application and Mechanism of Aspirin-Modified Chitosan in Small-Diameter Vascular Grafts DOI
Siyuan Zhou,

Lei Li,

Jianhua Cao

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 8(1), P. 763 - 773

Published: Dec. 30, 2024

Chitosan is generally considered to be a procoagulant effect, which may cause adverse phenomena such as blood clotting when used in small-diameter vascular grafts. However, it also shows good biocompatibility and anti-inflammatory properties, can facilitate reconstruction. Therefore, significant transition the effect of chitosan from coagulation promotion antiplatelet while still harnessing its bioactivity. The mechanism primarily attributed presence protonated amino groups molecular chain. If number reduced, will diminished well. Aspirin has strong function, structure contains numerous active carboxyl groups, couple with chitosan. Aspirin-modified retains biological activity imparting an effect. In our study, we heparinized electrospun graft substrate coated aspirin-modified create functional graft. index remained above 80% after 45 min, platelet activation degree was only 4.03%. Additionally, maintained complete patency stable flow 4 weeks implantation largely rebuilt.

Language: Английский

Antifouling Polymer Coatings for Bioactive Surfaces DOI
Yang He, Yichen Wang, Lihua Yao

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Bioactive surfaces play a pivotal role in biomedical applications by enabling precise biological interactions through immobilized functional molecules. However, their performance is often hindered nonspecific protein adsorption and cell adhesion. Antifouling polymer coatings have emerged as an effective solution, creating hydration barriers to preserve functionality reduce biofouling. This review provides overview of the recent advances development antifouling for bioactive surfaces, with particular focus on nonionic polymers, such polyethylene glycol (PEG), zwitterionic polymers like poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC). Among them, unique charge-balanced structures, exhibit exceptional hydration, resistance, stability, making them particularly promising applications. In addition, key these including use anticoagulant materials, antibacterial coatings, biosensor interfaces, are also discussed. The discussion concludes address field's challenges future directions, highlighting need innovative materials that balance properties, biocompatibility, long-term stability both clinical industrial use. aims latest advancements provide insights into optimizing multifunctional meet evolving dynamic demands field.

Language: Английский

Citations

0
Transition from Procoagulation to Antiplatelet Effect: Application and Mechanism of Aspirin-Modified Chitosan in Small-Diameter Vascular Grafts DOI
Siyuan Zhou,

Lei Li,

Jianhua Cao

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 8(1), P. 763 - 773

Published: Dec. 30, 2024

Chitosan is generally considered to be a procoagulant effect, which may cause adverse phenomena such as blood clotting when used in small-diameter vascular grafts. However, it also shows good biocompatibility and anti-inflammatory properties, can facilitate reconstruction. Therefore, significant transition the effect of chitosan from coagulation promotion antiplatelet while still harnessing its bioactivity. The mechanism primarily attributed presence protonated amino groups molecular chain. If number reduced, will diminished well. Aspirin has strong function, structure contains numerous active carboxyl groups, couple with chitosan. Aspirin-modified retains biological activity imparting an effect. In our study, we heparinized electrospun graft substrate coated aspirin-modified create functional graft. index remained above 80% after 45 min, platelet activation degree was only 4.03%. Additionally, maintained complete patency stable flow 4 weeks implantation largely rebuilt.

Language: Английский

Citations

0