Dual-Function Hydrogel Coating on Silicone Urinary Catheters with Durable Antibacterial Property and Lubricity

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 128 - 128

Published: Feb. 10, 2025

Silicone urinary catheters are broadly employed in medical practice. However, they susceptible to inducing catheter-associated tract infections (CAUTIs) due bacterial adherence the catheter's surface, and exhibit a high friction coefficient, which can greatly affect their effectiveness functionality. Thus, development of silicone catheter with antibacterial properties lubricity is strong demand. We hereby developed poly(vinyl acetate) carrier coating load chlorhexidine acetate applied hydrogel primarily composed polyvinylpyrrolidone (PVP) poly(ethylene glycol) diacrylate (PEGDA), was then coated onto cured through thermal curing process could provide lubricity. Subsequently, we analyzed its surface characteristics assessed property, lubricity, cytotoxicity, potential for vaginal irritation. The findings from Fourier transform infrared spectrometer (FTIR), scanning electron microscope (SEM), water contact angle (WCA), inhibition zone measurements, coefficient analysis confirmed successful modification catheter. Additionally, outcomes cytotoxicity irritation assessments demonstrated that dual-function coating-coated outstanding biocompatibility. This study illustrates prepared possess durable thus gives them broad clinical application prospects.

Language: Английский

Renewable and Switchable Biofunctional Modification of Poly(dimethylsiloxane) Surfaces via Host–Guest Interactions for Enhanced Capture of Circulating Tumor Cells in Microfluidics

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Circulating tumor cells (CTCs) are crucial for understanding cancer metastasis. Poly(dimethylsiloxane) (PDMS) microfluidic chips utilizing aptamers (APTs) effectively separate CTCs, but the hydrophobicity of PDMS causes issues with nonspecific adsorption and reduces cell viability. Therefore, it is imperative to develop innovative surface modification techniques enhance its biocompatibility optimize performance in applications. In this study, oligo(ethylene glycol) methacrylate (OEGMA) adamantane-modified OEGMA were copolymerized onto an initiator-containing surface. Poly(OEGMA) prevents adsorption, biotin-modified β-cyclodextrin (β-CD) was introduced through host-guest interaction between β-CD adamantane. By using biotin-streptavidin interaction, streptavidin (TD05 APT Sgc8 APT) sequentially immobilized on copolymer-grafted substrate. The data indicate that substrate functionalized TD05 achieved a capture efficiency 91% selectivity 30.2 Ramos cells, while 93% 33.3 CEM cells. Furthermore, treating APT-functionalized surfaces sodium dodecyl sulfate released component, allowing regeneration switching biofunctionality by reimmobilizing or APT. Finally, modified strategy high (96% cells) (11.4 9.2 cells). chemistry endows renewable switchable biofunctionality, offering insights into potential applications isolation enrichment CTCs.

Language: Английский

Synthesis of Novel vesicle-like polysaccharide derivative for Boosting Water Lubrication of Silicon-based devices

Tribology International, Journal Year: 2025, Volume and Issue: unknown, P. 110796 - 110796

Published: May 1, 2025

Language: Английский