Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside DOI Creative Commons
Yifan Ding, Fan Li, Yunyun Wang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 313 - 313

Published: Feb. 28, 2025

Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression IDD driven by excessive oxidative stress, inflammation, apoptosis, fibrosis, which disrupt the balance between anabolic catabolic processes, extracellular matrix (ECM) degradation IDD. Current treatment options, such as conservative therapy surgical intervention, are limited in halting disease often exacerbate adjacent discs. This review highlights challenges treating IDD, particularly due drug delivery efficiency intervertebral (IVD). It explores potential nanobiomedicine various nanomaterial-based systems, including nanoparticles, microspheres, gene-nanocomplexes, fullerene, exosomes, nanomaterial-composite hydrogels. These advanced systems can enhance targeted delivery, improve local concentration, sustain retention within IVD, offering promising therapeutic strategies address also examines effects these nanomaterials on focusing their impact metabolism, stem cell migration differentiation, aiming provide innovative for regeneration.

Language: Английский

Microenvironment Remodeling Microgel Repairs Degenerated Intervertebral Disc via Programmed Delivery of MicroRNA-155 DOI
Chuan Fei Guo,

Yuheng Liu,

Fei Ma

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

The progression of intervertebral disc degeneration (IVDD) is associated with increased cell apoptosis and reduced extracellular matrix (ECM) production, both which are driven by ongoing inflammation. Thus, alleviating the acidic inflammatory microenvironment mitigating nucleus pulposus cells (NPCs) essential for (IVD) regeneration. Regulating pH levels in local environment can reduce inflammation promote tissue recovery. In this study, a lactic acid-capturing microgel carrying functionalized miRNA-155 nanocarrier was designed IVD microRNA-155 loaded into NPC-targeted nanogel via host–guest binding. miR-155 (NGM) achieved acid-sensitive release miRNA-155, resulting rapid regulation apoptosis. Moreover, SS31, dissociated from network, had ability to regulate mitochondrial metabolism. constructed using metalloproteinase-responsive peptide. chitosan coating on system ingeniously employed capture acid enable pH-responsive dissociation, thereby protect viability facilitate delivery NGM. effectively promoted regeneration preventing NPC

Language: Английский

Citations

0
Compliant immune response of silk-based biomaterials broadens application in wound treatment DOI Creative Commons
Zhiqiang Tian, Hong Chen, Ping Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 12, 2025

The unique properties of sericin and silk fibroin (SF) favor their widespread application in biopharmaceuticals, particularly wound treatment bone repair. immune response directly influences healing cycle, the extensive immunomodulatory functions silk-based nanoparticles hydrogels have attracted wide attention. However, different silk-processing methods may trigger intense system resistance after implantation into body. In this review, we elaborate on inflammation responses caused by SF also explore anti-inflammatory regulatory functions. More importantly, describe latest research progress enhancing immunotherapeutic effects composite materials prepared from a mechanistic perspective. This review will provide useful reference for using correct processes to exploit biomaterials treatments.

Language: Английский

Citations

0
Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside DOI Creative Commons
Yifan Ding, Fan Li, Yunyun Wang

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 313 - 313

Published: Feb. 28, 2025

Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. The progression IDD driven by excessive oxidative stress, inflammation, apoptosis, fibrosis, which disrupt the balance between anabolic catabolic processes, extracellular matrix (ECM) degradation IDD. Current treatment options, such as conservative therapy surgical intervention, are limited in halting disease often exacerbate adjacent discs. This review highlights challenges treating IDD, particularly due drug delivery efficiency intervertebral (IVD). It explores potential nanobiomedicine various nanomaterial-based systems, including nanoparticles, microspheres, gene-nanocomplexes, fullerene, exosomes, nanomaterial-composite hydrogels. These advanced systems can enhance targeted delivery, improve local concentration, sustain retention within IVD, offering promising therapeutic strategies address also examines effects these nanomaterials on focusing their impact metabolism, stem cell migration differentiation, aiming provide innovative for regeneration.

Language: Английский

Citations

0