Preparation and Optimization of a Polyhydroxyoctanoate–Hydroxyapatite Composite Available to Scaffolds in Implantable Devices

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 730 - 730

Published: Feb. 6, 2025

Biomaterials represent a distinct class of materials used in various medical applications, such as replicating the shape or function damaged tissue caused by disease trauma. The increasing focus on polyhydroxyalkanoate (PHA) research can be attributed to their properties, biodegradability, biocompatibility, and bioresorbability. PHAs incorporated into polymeric complexes combined with bioceramics bioactive substances. Films PHO-HAp-Curcumin were prepared, optimization studies conducted using Design-Expert software (Stat-Ease 360-Trial Version). effects independent variables (amount PHO, HAp, curcumin) film thickness, curcumin release studied. Statistical modeling revealed significant interactions among components, 2FI quadratic models providing strong predictive accuracy. interaction HAp PHO amounts (X2X3) has effect biodegradability (Y1) thickness (Y3). For degree cumulative (CDR), there was no between (curcumin-X1, HAp-X2, PHO-X3). Optimized exhibited maximum desirability 0.777 1 mg curcumin, 100 172.31 PHO. A morphological analysis optimized rough, particle-rich surface favorable for biomedical use. findings highlight promise composite films advancing engineering.

Language: Английский

Advancements in Biomaterials for Regenerative Medicine Through Tissue Engineering in Quest of Sustainability

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Language: Английский