Integration of SERS with cutting-edge technologies for enhanced detection of drug-resistant microorganisms and optimized drug susceptibility testing DOI
Shuo Zheng, Qian Wang,

Tuotuo Zhang

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 542, P. 216828 - 216828

Published: June 4, 2025

Language: Английский

Molecule-resolvable SERSome for metabolic profiling DOI
Xinyuan Bi, Xiaohang Qian,

Bingsen Xue

et al.

Chem, Journal Year: 2025, Volume and Issue: unknown, P. 102528 - 102528

Published: April 1, 2025

Citations

2

Artificial Intelligence-Powered Surface-Enhanced Raman Spectroscopy for Biomedical Applications DOI
Xinyuan Bi, X. Ai, Zongyu Wu

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Citations

0

Advancing clinical diagnostics: the potential of analytical Raman spectroscopy in oncology, dermatology, and diabetes DOI
Rabia’tul A’dawiah, Alex Jie Yap,

Poongkulali Rajarahm

et al.

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 56

Published: April 4, 2025

Language: Английский

Citations

0

Precision oncology through SERS: emerging approaches for improved cancer diagnosis and prognosis DOI
Eduardo García‐Rico, Miguel A. Correa‐Duarte, Ramón A. Álvarez‐Puebla

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4

Published: April 28, 2025

Language: Английский

Citations

0

Centrifugation-Induced Stable Colloidal Silver Nanoparticle Aggregates for Reproducible Surface-Enhanced Raman Scattering Detection DOI Creative Commons

Taofei Zhou,

Zhiyang Zhang

Biosensors, Journal Year: 2025, Volume and Issue: 15(5), P. 298 - 298

Published: May 8, 2025

Colloidal noble metal nanoparticle aggregates have demonstrated significant advantages in surface-enhanced Raman scattering (SERS) analysis, particularly for online detection, due to their excellent optical properties, spatial homogeneity, and fluidic compatibility. However, conventional chemically induced aggregation methods (such as salt-induced aggregation) suffer from uncontrolled aggregation, limited stability, narrow detection windows, which restrict quantitative long-term applications. In this study, we developed a non-chemical method fabricating stable colloidal uniform β-cyclodextrin-stabilized silver nanoparticles (β-CD@AgNPs) via centrifugation. By precisely controlling the addition rate of nitrate, synthesized with size. Surprisingly, these can form highly dispersed homogeneous simply centrifugation, is completely different behavior traditional ligand-modified nanoparticles. Notably, resulting exhibit SERS enhancement, enabling sensitive various dyes at nanomolar levels. Furthermore, they maintain signal (RSD = 6.99%) over window exceeding 1 h, markedly improving stability reproducibility compared aggregates. Additionally, using pyocyanin model analyte, evaluated performance (LOD 0.2 nM), achieving satisfactory recovery (82–117%) spiked samples drinking water, lake tap water. This study provides facile strategy substrates paves way advancement applications analytical sciences.

Language: Английский

Citations

0

µ-Raman Spectroscopic Temperature Dependence Study of Biomimetic Lipid 1,2-Diphytanoyl-sn-glycero-3-phosphocholine DOI Creative Commons
Carmen Rizzuto, Antonello Nucera,

Irene Barba Castagnaro

et al.

Biomimetics, Journal Year: 2025, Volume and Issue: 10(5), P. 308 - 308

Published: May 11, 2025

Raman spectroscopy is one of the best techniques for obtaining information concerning physical-chemical interactions between a lipid and solvent. Phospholipids in water are main elements cell membranes and, by means their chemical physical structures, cells can interact with other biological molecules (i.e., proteins vitamins) express own functions. Phospholipids, due to amphiphilic structure, form biomimetic which useful studying cellular drug delivery. Synthetic systems such as DPhPC-based liposomes replicate key properties membranes. Among different models, phospholipid mimetic membrane models lamellar vesicles have been greatly supported. In this work, system, deuterium solution (50 mM) synthetic 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhDC), studied using μ-Raman wide temperature range from -181.15 °C up 22.15 °C, including following temperatures: -146.15 -111.15 -76.15 -61.15 -46.15 -31.15 -16.15 -1.15 14.15 °C. Based on evidence, phase transitions function shown grouped into five classes, where corresponding modes describe stretching (C-N) bond choline head group (gauche) asymmetric (O-P-O) bond. The acquisition each spectrum characterizes rocking mode methylene acyl chain. These findings enhance our understanding role artificial lipids complex provide valuable insights optimizing use biosensing applications. Although stability DPhPC known, collected data suggest subtle molecular rearrangements, possibly hydration second-order transitions, relevant modeling

Language: Английский

Citations

0

Polymer-Based Raman/PET Dual-Modal Probe for Preoperative Tumor Diagnosis and Intraoperative Image-Guided Surgery and Phototherapy DOI
Yuanyuan Qiu, Qi Zhu, Kai Cui

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Integration of Raman imaging and positron emission tomography (PET) holds great promise for providing complementary information precise cancer diagnosis imaging-guided therapy. However, current existing Raman/PET dual-modal probes primarily rely on surface-enhanced scattering, raising clinical concerns about the biosafety substrates. Herein, we developed a novel substrate-free probe-[18F]-AS-DPPT-TT NPs, which integrates biocompatible polymer DPPT-TT that possesses strong signals photothermal effects, along with radiolabeling by short-lived 18F radionuclide functionalization tumor-targeting AS1411 aptamer. The [18F]-AS-DPPT-TT NPs generate ultrasensitive resonance under 785 nm excitation, due to their absorption peak closely matching excitation light, exhibit significant effects tumor cell ablation 808 excitation. In orthotopic colon mouse models, enabled preoperative PET high-contrast whole-body localization simultaneously provided intraoperative accurate boundary delineation micrometastasis detection (as small as 0.58 mm × 0.32 mm). Moreover, surgery combined therapy achieved complete elimination primary metastatic tumors, significantly decreasing recurrence rates. This probe effectively combines strengths imaging, robust platform comprehensive management from planning intervention.

Language: Английский

Citations

0

Surface‐Enhanced Raman Scattering Nanotags: Design Strategies, Biomedical Applications, and Integration of Machine Learning DOI

Isabella Vasquez,

Ruiyang Xue, Indrajit Srivastava

et al.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2025, Volume and Issue: 17(3)

Published: May 1, 2025

ABSTRACT Surface‐enhanced Raman scattering (SERS) is a transformative technique for molecular identification, offering exceptional sensitivity, signal specificity, and resistance to photobleaching, making it invaluable disease diagnosis, monitoring, spectroscopy‐guided surgeries. Unlike traditional spectroscopy, which relies on weak signals, SERS amplifies signals using plasmonic nanoparticles, enabling highly sensitive detection. This technological advancement has led the development of nanotags with remarkable multiplexing capabilities biosensing applications. Recent progress expanded use in bioimaging, theranostics, more recently, liquid biopsy. The distinction between conventional spectroscopy highlighted, followed by an exploration assembly nanotags. Significant bioimaging summarized, including vitro studies 2D/3D cell cultures, ex vivo tissue imaging, diagnostics, spectroscopic‐guided surgery tumor margin delineation, biopsy tools detecting cancer SARS‐CoV‐2. A particular focus integration machine learning (ML) deep algorithms boost nanotag efficacy biopsies. Finally, addresses challenges clinical translation offers strategies overcome these obstacles.

Language: Английский

Citations

0

Phase Transition Control of pNIPAAm-b-pMMA Thin Films via UV/Ozone Irradiation and Direct Immersion Annealing for Biomedical Applications DOI
Moein Fadavi, Farhang Abbasi, Morteza Nasiri

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 27, 2025

Poly(N-isopropylacrylamide) (pNIPAAm) and its copolymers with poly(methyl methacrylate) (pMMA), due to their lower critical solution temperature (LCST) within the physiological range, have attracted attention in many studies as responsive surfaces for cell sheet growth. The behavior of pNIPAAm block copolymer pMMA (pNIPAAm-b-pMMA) films is not fully understood. In this study, effects ultraviolet/ozone (UV/O3), interdiffusion, direct immersion annealing (DIA) treatments on responsiveness adhesion spin-coated thin pNIPAAm-b-pMMA were investigated. water contact angle (WCA) measurements used record changes hydrophilicity relaxation time immersed deionized water, well during cyclic measurements. Atomic force microscopy was utilized track phase transitions over three complete continuous thermal cycles. transition across LCST range remains insufficiently understood, particularly relation influence different treatment types underlying chemophysical mechanisms that regulate orientation functional groups along polymer chains. we address these gaps by examining how factors, globule-to-coil chains, impact films' thermoresponsiveness required detachment. This study evaluated potential utilizing straightforward environmentally sustainable methods producing culture dishes alternatives conventional, costly, detrimental techniques. findings confirmed significant promise intended applications.

Language: Английский

Citations

0

One-step microwave-assisted ionothermal synthesis of AuNPs/CTF for sensitive surface-enhanced Raman spectroscopy detection DOI

Linjing Su,

Jingyan Xu, Zhi Zhang

et al.

Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100755 - 100755

Published: May 27, 2025

Language: Английский

Citations

0