Piezoelectric Amplification of Cascade Enzymatic Catalysis and Nanomotor Propulsion for Synergistic Electrodynamic‐Starvation Tumor Therapy DOI

Zhanlin Zhang,

Kun Wei,

Jie Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Piezoelectrodynamic therapy (PEDT) is compromised by hypoxia dilemma of tumors, while starvation constrained insufficient enzyme activities. To address these challenges, Janus piezoelectric nanoparticles (NPs) are proposed to spatially immobilize glucose oxidase (GOx) and catalase (CAT), enabling potential‐amplified activities synergistic PEDT‐starvation tumor therapy. Here hollow barium titanate (hBT) NPs synthesized using SiO 2 templates, followed partial Au deposition via the Pickering emulsion‐masking method create hBT@Au NPs, which then conjugated with GOx CAT on opposing sides yield C‐hBT@Au‐G NPs. The structure hBT enhances flexibility deformation under ultrasonication, Schottky heterojunctions layers promote charge carrier transfer, amplifying effects free electron transfer boost Piezoelectric field‐enhances selective cell internalization PEDT generation reactive oxygen species (ROS), coupled self‐propagated GOx/CAT cascades, intensify cytotoxicities deplete intracellular adenosine triphosphate. architecture, ultrasonic cavitation, O collaboratively drive robust propulsion for efficient NP accumulation deep ROS penetration into tissues, thereby achieving full suppression negligible systemic toxicity. This design overcomes delivery barriers accumulation, intratumoral penetration, cellular uptake synergizes

Language: Английский

Piezoelectric Amplification of Cascade Enzymatic Catalysis and Nanomotor Propulsion for Synergistic Electrodynamic‐Starvation Tumor Therapy DOI

Zhanlin Zhang,

Kun Wei,

Jie Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Abstract Piezoelectrodynamic therapy (PEDT) is compromised by hypoxia dilemma of tumors, while starvation constrained insufficient enzyme activities. To address these challenges, Janus piezoelectric nanoparticles (NPs) are proposed to spatially immobilize glucose oxidase (GOx) and catalase (CAT), enabling potential‐amplified activities synergistic PEDT‐starvation tumor therapy. Here hollow barium titanate (hBT) NPs synthesized using SiO 2 templates, followed partial Au deposition via the Pickering emulsion‐masking method create hBT@Au NPs, which then conjugated with GOx CAT on opposing sides yield C‐hBT@Au‐G NPs. The structure hBT enhances flexibility deformation under ultrasonication, Schottky heterojunctions layers promote charge carrier transfer, amplifying effects free electron transfer boost Piezoelectric field‐enhances selective cell internalization PEDT generation reactive oxygen species (ROS), coupled self‐propagated GOx/CAT cascades, intensify cytotoxicities deplete intracellular adenosine triphosphate. architecture, ultrasonic cavitation, O collaboratively drive robust propulsion for efficient NP accumulation deep ROS penetration into tissues, thereby achieving full suppression negligible systemic toxicity. This design overcomes delivery barriers accumulation, intratumoral penetration, cellular uptake synergizes

Language: Английский

Citations

0