Crystal Violet-Loaded Bi(III)-Based Metal–Organic Framework Boosting Enhanced Photothermal Effect for Breast Cancer Treatment DOI
Xue Wu, Shun Yang, Mingyu Li

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Recently, metal-organic frameworks (MOFs) have emerged as promising platforms to fabricate photothermal therapeutic materials cure tumors, but the toxic heavy metals in many MOFs may pose great threats normal cells. In consideration of low toxicity bismuth, herein we made efforts synthesize porous bismuth-based (Bi-MOFs) construct conversion for cancer treatment. By reaction 4,4',4''-tricarboxylic triphenylamine (H3TCA) and Bi(NO3)3 under solvothermal conditions, a Bi-MOF was obtained with formula {[Bi2(TCA)2(H2O)3]·6DMF·21H2O}n (Bi-TCA). Structural analysis revealed that complex Bi-TCA displayed three-dimensional (3D) coordination framework featuring abundant accessible channels cages porosity 73.3% according calculating results PLATON. Due high porosity, could effectively encapsulate dye crystal violet (CV) into voids resulting dye-loaded composite CV@Bi-TCA exhibited extended red-shifted light-absorbing property enhanced capability 455 nm laser irradiation. Further anticancer experiments demonstrated efficiently inhibit growth breast cells both vitro vivo This work promote investigations on low-toxicity Bi-MOFs therapy.

Language: Английский

Crystal Violet-Loaded Bi(III)-Based Metal–Organic Framework Boosting Enhanced Photothermal Effect for Breast Cancer Treatment DOI
Xue Wu, Shun Yang, Mingyu Li

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Recently, metal-organic frameworks (MOFs) have emerged as promising platforms to fabricate photothermal therapeutic materials cure tumors, but the toxic heavy metals in many MOFs may pose great threats normal cells. In consideration of low toxicity bismuth, herein we made efforts synthesize porous bismuth-based (Bi-MOFs) construct conversion for cancer treatment. By reaction 4,4',4''-tricarboxylic triphenylamine (H3TCA) and Bi(NO3)3 under solvothermal conditions, a Bi-MOF was obtained with formula {[Bi2(TCA)2(H2O)3]·6DMF·21H2O}n (Bi-TCA). Structural analysis revealed that complex Bi-TCA displayed three-dimensional (3D) coordination framework featuring abundant accessible channels cages porosity 73.3% according calculating results PLATON. Due high porosity, could effectively encapsulate dye crystal violet (CV) into voids resulting dye-loaded composite CV@Bi-TCA exhibited extended red-shifted light-absorbing property enhanced capability 455 nm laser irradiation. Further anticancer experiments demonstrated efficiently inhibit growth breast cells both vitro vivo This work promote investigations on low-toxicity Bi-MOFs therapy.

Language: Английский

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