Oxygen Nanobubbles Enhance ICG/Fe(III)-Mediated Dual-Modal Therapy To Induce Ferroptosis in Tumor Treatment DOI
Yang Li, Weihua Zhang, Yan Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Noninvasive therapies such as photodynamic therapy (PDT) and chemodynamic (CDT), which rely on reactive oxygen species (ROS), are gaining attention for their low toxicity. However, single-modal treatments have individual limitations that restrict the therapeutic efficacy. Fe(III) can coordinate with hydrophilic regions of indocyanine green (ICG) molecules to form ICG/Fe(III) complex, making it a promising dual-modal agent combined PDT CDT. coordination leads aggregation quenching ICG, hindering its application in therapy. We innovatively utilize nanobubbles, prepared solely from water oxygen, significantly reverse aggregation-induced thereby enhancing stability aqueous environments. In this system, assembles at nanobubble interface, coordinating ICG's ICG/Fe(III)-NBs. The nanobubbles boost efficiency by improving complex content, while achieves CDT generating hydroxyl radicals (•OH) through Fenton reaction. This dual-modality treatment disrupts tumor's redox balance, induces ferroptosis, demonstrates strong antitumor efficacy, reducing tumor volume 34% initial size mice. strategy offers clinically viable approach cancer treatment.

Language: Английский

Oxygen Nanobubbles Enhance ICG/Fe(III)-Mediated Dual-Modal Therapy To Induce Ferroptosis in Tumor Treatment DOI
Yang Li, Weihua Zhang, Yan Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Noninvasive therapies such as photodynamic therapy (PDT) and chemodynamic (CDT), which rely on reactive oxygen species (ROS), are gaining attention for their low toxicity. However, single-modal treatments have individual limitations that restrict the therapeutic efficacy. Fe(III) can coordinate with hydrophilic regions of indocyanine green (ICG) molecules to form ICG/Fe(III) complex, making it a promising dual-modal agent combined PDT CDT. coordination leads aggregation quenching ICG, hindering its application in therapy. We innovatively utilize nanobubbles, prepared solely from water oxygen, significantly reverse aggregation-induced thereby enhancing stability aqueous environments. In this system, assembles at nanobubble interface, coordinating ICG's ICG/Fe(III)-NBs. The nanobubbles boost efficiency by improving complex content, while achieves CDT generating hydroxyl radicals (•OH) through Fenton reaction. This dual-modality treatment disrupts tumor's redox balance, induces ferroptosis, demonstrates strong antitumor efficacy, reducing tumor volume 34% initial size mice. strategy offers clinically viable approach cancer treatment.

Language: Английский

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