Bioinspired 3D‐Printed NIR‐Responsive MXene‐Based Multifunctional Eutectogel Microneedles for Personalized Infected Wound Healing DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Infected wound healing remains a significant clinical challenge, demanding innovative therapeutic strategies to simultaneously address bacterial elimination, tissue regeneration, and controlled drug delivery. Inspired by the hierarchical structure of crocodile teeth, bioinspired, 3D‐printed microneedle patch integrating Mxene nanosheets polymerizable deep eutectic solvent (PDES) composed vinyl pyrrolidone (VP), itaconic acid (IA), N‐isopropyl acrylamide (NIPAM) is developed. The resulting MXene‐based eutectogel (MF‐MXene@MN) combines photothermal responsiveness, antioxidant activity, temperature‐triggered release for conversion reactive oxygen species (ROS) scavenging. gradient‐height design inspired teeth enhances adhesion, while DLP 3D printing enables personalized dressing geometries with <50 µm resolution. In vitro in vivo studies demonstrated 94.88% closure rate within 10 days, 3.2‐fold increased angiogenesis, 68% reduced viability ( S. aureus : 32.59%; E. coli 48.17% under NIR), pH‐/temperature‐responsive mangiferin (88.3% cumulative via 5 NIR cycles). These synergistic functions promote healing, offering superior antibacterial ability, regeneration promotion, control compared traditional dressings systems. This multifunctional platform integrates bioinspired design, stimuli‐responsive materials, additive manufacturing, providing transformative solution precision management.

Language: Английский

Nanozymes as catalysts for accelerated healing of diabetic wounds DOI Creative Commons
Man Li, Hafez Jafari, Oseweuba Valentine Okoro

et al.

Published: April 1, 2025

Language: Английский

Citations

0
Bioinspired 3D‐Printed NIR‐Responsive MXene‐Based Multifunctional Eutectogel Microneedles for Personalized Infected Wound Healing DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Infected wound healing remains a significant clinical challenge, demanding innovative therapeutic strategies to simultaneously address bacterial elimination, tissue regeneration, and controlled drug delivery. Inspired by the hierarchical structure of crocodile teeth, bioinspired, 3D‐printed microneedle patch integrating Mxene nanosheets polymerizable deep eutectic solvent (PDES) composed vinyl pyrrolidone (VP), itaconic acid (IA), N‐isopropyl acrylamide (NIPAM) is developed. The resulting MXene‐based eutectogel (MF‐MXene@MN) combines photothermal responsiveness, antioxidant activity, temperature‐triggered release for conversion reactive oxygen species (ROS) scavenging. gradient‐height design inspired teeth enhances adhesion, while DLP 3D printing enables personalized dressing geometries with <50 µm resolution. In vitro in vivo studies demonstrated 94.88% closure rate within 10 days, 3.2‐fold increased angiogenesis, 68% reduced viability ( S. aureus : 32.59%; E. coli 48.17% under NIR), pH‐/temperature‐responsive mangiferin (88.3% cumulative via 5 NIR cycles). These synergistic functions promote healing, offering superior antibacterial ability, regeneration promotion, control compared traditional dressings systems. This multifunctional platform integrates bioinspired design, stimuli‐responsive materials, additive manufacturing, providing transformative solution precision management.

Language: Английский

Citations

0