Porphyrin-Based Metal–Organic Frameworks for PD-L1 Detection via “Coordination Disaggregation-Induced Enhancement” Strategy DOI

Weiming Gong,

Xiaoran Wu,

Dan Ren

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Porphyrins, known for their exceptional photoelectrochemical properties and high luminescence, are promising candidates electrochemiluminescence (ECL) applications. However, tendency to aggregate in aqueous solutions due π–π stacking leads luminescence quenching reduced efficiency. To address this, we developed a "coordination disaggregation-induced enhancement" strategy, utilizing metal–organic frameworks (MOFs) as stable platforms immobilizing porphyrin. These porphyrin-based MOFs not only increase the loading of luminescent groups suppress aggregation-caused (ACQ) effect but also enhance electron transfer via uniform dispersion pyrrole N porphyrin ligand, thereby improving ECL intensity. Additionally, they exhibit favorable biocompatibility low toxicity, making them suitable biomedical By combining donors with PDA@MnO2 composites quenchers, constructed quenching-type immunosensor detecting programmed death ligand 1 (PD-L1). This sensor achieves detection range 10 fg/mL 100 ng/mL, limit 2.48 fg/mL, which demonstrates great potential highly sensitive biomarker applications early cancer diagnosis other medical diagnostics.

Language: Английский

Porphyrin-Based Metal–Organic Frameworks for PD-L1 Detection via “Coordination Disaggregation-Induced Enhancement” Strategy DOI

Weiming Gong,

Xiaoran Wu,

Dan Ren

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Porphyrins, known for their exceptional photoelectrochemical properties and high luminescence, are promising candidates electrochemiluminescence (ECL) applications. However, tendency to aggregate in aqueous solutions due π–π stacking leads luminescence quenching reduced efficiency. To address this, we developed a "coordination disaggregation-induced enhancement" strategy, utilizing metal–organic frameworks (MOFs) as stable platforms immobilizing porphyrin. These porphyrin-based MOFs not only increase the loading of luminescent groups suppress aggregation-caused (ACQ) effect but also enhance electron transfer via uniform dispersion pyrrole N porphyrin ligand, thereby improving ECL intensity. Additionally, they exhibit favorable biocompatibility low toxicity, making them suitable biomedical By combining donors with PDA@MnO2 composites quenchers, constructed quenching-type immunosensor detecting programmed death ligand 1 (PD-L1). This sensor achieves detection range 10 fg/mL 100 ng/mL, limit 2.48 fg/mL, which demonstrates great potential highly sensitive biomarker applications early cancer diagnosis other medical diagnostics.

Language: Английский

Citations

1