MOF-Loaded Biotemplated Magnetic Microrobots for Targeted Chemo-Photothermal Therapy DOI

Bo Gu,

Jun Cai, De Gong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(19), P. 27806 - 27815

Published: April 30, 2025

Magnetic micro/nanorobots have been extensively studied for their potential in targeted drug delivery. However, facile fabrication of magnetic microrobots with good biocompatibility and enhanced chemo-photothermal therapeutic efficiency is still challenging. Here, we proposed a novel strategy mass production MOF-loaded biotemplated based on Chlorella verified its feasibility application therapy. In this approach, Fe3O4 NPs were densely loaded inside cells magnetization, layer PDA was coated extracellularly photothermal conversion. Subsequently, ZIF-8 nanoparticles grown situ to achieve highly efficient loading anticancer doxorubicin (DOX), which could also be released via pH/light stimuli. The as-prepared microrobot precise propulsion under rotating field, rapid heating an 808 nm near-infrared (NIR) laser. Furthermore, such exhibited low cell toxicity therapy effects, by series vitro tests. Due superior versatility, the demonstrated significant

Language: Английский

Biotemplated Diatom Microrobots for Dual-Drug Delivery in Targeted Neuroblastoma Therapy DOI

Chao Gao,

Jian Xu,

Shuangxi Xie

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Neuroblastoma, a highly malignant pediatric tumor, demands innovative targeted drug delivery strategies to overcome the limitations of conventional therapies. In this study, we developed magnetic diatom microrobots (DMs) using frustules as biotemplates, leveraging their natural hierarchical porosity and biocompatibility. Functionalized with amino groups folic acid, these demonstrated enhanced conjugation tumor-targeting capabilities. Designed carry either cisplatin (CDDP) or paclitaxel (PTX), DMs facilitated complementary therapeutic effects through pH-responsive release, enabling synergistic neuroblastoma therapy. Magnetic actuation tests confirmed multimodal propulsion precise motion control. vitro experiments efficacy reduced off-target compared those approaches. These diatom-templated microrobots, facile fabrication superior performance, represent promising platform for advanced cancer

Language: Английский

Citations

0
MOF-Loaded Biotemplated Magnetic Microrobots for Targeted Chemo-Photothermal Therapy DOI

Bo Gu,

Jun Cai, De Gong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(19), P. 27806 - 27815

Published: April 30, 2025

Magnetic micro/nanorobots have been extensively studied for their potential in targeted drug delivery. However, facile fabrication of magnetic microrobots with good biocompatibility and enhanced chemo-photothermal therapeutic efficiency is still challenging. Here, we proposed a novel strategy mass production MOF-loaded biotemplated based on Chlorella verified its feasibility application therapy. In this approach, Fe3O4 NPs were densely loaded inside cells magnetization, layer PDA was coated extracellularly photothermal conversion. Subsequently, ZIF-8 nanoparticles grown situ to achieve highly efficient loading anticancer doxorubicin (DOX), which could also be released via pH/light stimuli. The as-prepared microrobot precise propulsion under rotating field, rapid heating an 808 nm near-infrared (NIR) laser. Furthermore, such exhibited low cell toxicity therapy effects, by series vitro tests. Due superior versatility, the demonstrated significant

Language: Английский

Citations

0