Peptide Coacervates: Formation, Mechanism, and Biological Applications DOI

Jiewei Yuan,

Y. Richard Yang, Kehua Dai

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Biomolecular coacervates, dynamic compartments formed via liquid-liquid phase separation (LLPS), are essential for orchestrating intracellular processes and have emerged as versatile tools in bioengineering. Peptides, with their modular amino acid sequences, exhibit unique potential coacervate design due to ability undergo LLPS while offering precise control over molecular architecture environmental responsiveness. Their simplicity, synthetic accessibility, tunability make peptide-based coacervates particularly attractive biomedical materials applications. However, the formation stability of these systems depend on a delicate balance intrinsic factors (e.g., sequence charge, hydrophobicity, chain length) extrinsic conditions pH, ionic strength, temperature), necessitating deeper understanding interplay. This review synthesizes recent advances mechanisms driving peptide coacervation, emphasizing how cues govern behavior. We further highlight groundbreaking applications, from drug delivery platforms protocell mimics, discuss strategies translate mechanistic insights into functional materials. By bridging fundamental principles innovative this work aims accelerate development programmable, multifunctional systems, roadmap next-generation biochemical technologies.

Language: Английский

Peptide Coacervates: Formation, Mechanism, and Biological Applications DOI

Jiewei Yuan,

Y. Richard Yang, Kehua Dai

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Biomolecular coacervates, dynamic compartments formed via liquid-liquid phase separation (LLPS), are essential for orchestrating intracellular processes and have emerged as versatile tools in bioengineering. Peptides, with their modular amino acid sequences, exhibit unique potential coacervate design due to ability undergo LLPS while offering precise control over molecular architecture environmental responsiveness. Their simplicity, synthetic accessibility, tunability make peptide-based coacervates particularly attractive biomedical materials applications. However, the formation stability of these systems depend on a delicate balance intrinsic factors (e.g., sequence charge, hydrophobicity, chain length) extrinsic conditions pH, ionic strength, temperature), necessitating deeper understanding interplay. This review synthesizes recent advances mechanisms driving peptide coacervation, emphasizing how cues govern behavior. We further highlight groundbreaking applications, from drug delivery platforms protocell mimics, discuss strategies translate mechanistic insights into functional materials. By bridging fundamental principles innovative this work aims accelerate development programmable, multifunctional systems, roadmap next-generation biochemical technologies.

Language: Английский

Citations

0