Nanozymes: Innovative Therapeutics in the Battle Against Neurodegenerative Diseases DOI Open Access
C. Duta, Carmen Beatrice Dogaru,

Corina Muscurel

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3522 - 3522

Published: April 9, 2025

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), amyotrophic lateral (ALS) and Huntington’s (HD), represent a significant challenge to global health due their progressive nature the absence of curative treatments. These disorders are characterized by oxidative stress, protein misfolding, neuroinflammation, which collectively contribute neuronal damage death. Recent advancements in nanotechnology have introduced nanozymes—engineered nanomaterials that mimic enzyme-like activities—as promising therapeutic agents. This review explores multifaceted roles nanozymes combating stress inflammation neurodegenerative conditions. By harnessing potent antioxidant properties, can effectively scavenge reactive oxygen species (ROS) restore redox balance, thereby protecting function. Their ability modify surface properties enhances targeted delivery biocompatibility, making them suitable for various biomedical applications. In this review, we highlight recent findings on design, functionality, potential nanozymes, emphasizing dual role addressing pathological features such as aggregation. synthesis current research underscores innovative proactive strategy halt progression improve patient outcomes disorders.

Language: Английский

The mucosal protein corona in local nanoparticle drug delivery DOI

A. Stern,

A. Petersen, Hannah C. Zierden

et al.

Published: March 1, 2025

Citations

0
Nanozymes: Innovative Therapeutics in the Battle Against Neurodegenerative Diseases DOI Open Access
C. Duta, Carmen Beatrice Dogaru,

Corina Muscurel

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3522 - 3522

Published: April 9, 2025

Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s (PD), multiple sclerosis (MS), amyotrophic lateral (ALS) and Huntington’s (HD), represent a significant challenge to global health due their progressive nature the absence of curative treatments. These disorders are characterized by oxidative stress, protein misfolding, neuroinflammation, which collectively contribute neuronal damage death. Recent advancements in nanotechnology have introduced nanozymes—engineered nanomaterials that mimic enzyme-like activities—as promising therapeutic agents. This review explores multifaceted roles nanozymes combating stress inflammation neurodegenerative conditions. By harnessing potent antioxidant properties, can effectively scavenge reactive oxygen species (ROS) restore redox balance, thereby protecting function. Their ability modify surface properties enhances targeted delivery biocompatibility, making them suitable for various biomedical applications. In this review, we highlight recent findings on design, functionality, potential nanozymes, emphasizing dual role addressing pathological features such as aggregation. synthesis current research underscores innovative proactive strategy halt progression improve patient outcomes disorders.

Language: Английский

Citations

0