Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy

Pharmaceutics, Journal Year: 2019, Volume and Issue: 11(7), P. 301 - 301

Published: June 30, 2019

Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent characteristics. HA, which is a linear anionic polymer, biocompatibility, biodegradability, non-immunogenicity, non-inflammatory, and non-toxicity properties. Various HA nanomedicines (i.e., micelles, nanogels, nanoparticles) can be prepared easily using assembly modification of functional groups such as carboxy, hydroxy N-acetyl groups. Nanometer-sized selectively deliver drugs or other molecules into tumor sites via their enhanced permeability retention (EPR) effect. In addition, interact with overexpressed receptors cells cluster determinant 44 (CD44) receptor for HA-mediated motility (RHAMM) degraded by family enzymes called hyaluronidase (HAdase) release molecules. By interaction degradation inside cells, allow targeting therapy. this article, recent studies about drug delivery systems, photothermal therapy, photodynamic diagnostics (because the high biocompatibility), colloidal stability, are reviewed strategies inorganic nanoparticles.

Language: Английский

---

Insights into maleimide-thiol conjugation chemistry: Conditions for efficient surface functionalization of nanoparticles for receptor targeting

Journal of Controlled Release, Journal Year: 2018, Volume and Issue: 282, P. 101 - 109

Published: March 9, 2018

Language: Английский

---

Tetrazole hybrids with potential anticancer activity

European Journal of Medicinal Chemistry, Journal Year: 2019, Volume and Issue: 178, P. 341 - 351

Published: May 28, 2019

Language: Английский

---

Dual-targeted nanomedicines for enhanced tumor treatment

Nano Today, Journal Year: 2018, Volume and Issue: 18, P. 65 - 85

Published: Jan. 8, 2018

Language: Английский

---

Reduction-sensitive polymeric nanomedicines: An emerging multifunctional platform for targeted cancer therapy

Advanced Drug Delivery Reviews, Journal Year: 2018, Volume and Issue: 132, P. 16 - 32

Published: May 23, 2018

Language: Английский

---

Potential Applications of Advanced Nano/Hydrogels in Biomedicine: Static, Dynamic, Multi‐Stage, and Bioinspired

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(45)

Published: Sept. 9, 2020

Abstract Novel advanced hydrogels can provide a versatile platform for controlled delivery and release of various cargos, with myriad biomedical applications. These gel‐based nanostructures possess good biocompatibility, biodegradability, flexibility, multifunctionality, respond to internal or external stimuli, adapt their surrounding environment. This new generation is not only capable serving as targeted drug vehicles, but they also perform variety tasks within living cells organisms. In this review, are classified static, dynamic, multi‐stage, bioinspired. They be used cell‐free gene expression platforms therapy. Administration nanogel‐based sprays act an immunovaccine priming macrophages toward the M1 phenotype avoid cancer recurrence following surgery. Nanogels serve dual biosensing capture liquid biopsies, recognize remove circulating from blood patients.

Language: Английский

---

Label-Free Electrochemical Sensor for CD44 by Ligand-Protein Interaction

Analytical Chemistry, Journal Year: 2019, Volume and Issue: 91(11), P. 7078 - 7085

Published: April 3, 2019

Detection of biomarkers in biosystems plays a key role advanced biodiagnostics for research and clinical use. Design new analytical platforms is challenging demand, addressing molecular capture subsequent quantitation. Herein, we developed label-free electrochemical sensor CD44 by ligand-protein interaction. We assembled carbon nanotube composites on the electrode to enhance electronic conductivity 6.2-fold reduce overpotential with shift 77 mV. conjugated hyaluronic acid (HA) surface nanotubes via electrostatic interaction between HA poly(diallyldimethylammonium chloride) (PDDA). Consequently, performed direct sensing dynamic range 0.01–100 ng/mL detection limit 5.94 pg/mL without any postlabeling amplification, comparable best current results. The also displayed high selectivity, reproducibility relative standard deviation (RSD, n = 5) 2.57%, long-term stability 14 days. demonstrated applications human serum cancer cells. Our work guides development more types interactions contributes design interfaces given diagnosis.

Language: Английский

---

pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells

Biomacromolecules, Journal Year: 2017, Volume and Issue: 19(2), P. 555 - 562

Published: Dec. 29, 2017

The clinical translation of protein drugs that act intracellularly is limited by the absence safe and efficient intracellular delivery vehicles. Here, pH-sensitive coiled-coil peptide-cross-linked hyaluronic acid nanogels (HA-cNGs) were designed investigated for targeted to CD44 overexpressing MCF-7 breast cancer cells. HA-cNGs obtained with a small size 176 nm from an equivalent mixture conjugates GY(EIAALEK)3GC (E3) GY(KIAALKE)3GC (K3) peptides, respectively, at pH 7.4 nanoprecipitation. Circular dichroism (CD) proved formation structures between E3 K3 peptides while fast uncoiling 5.0. showed facile loading cytochrome C (CC) greatly accelerated CC release under mild acidic conditions (18.4%, 76.8%, 91.4% in 24 h 7.4, 6.0, 5.0, respectively). Confocal microscopy flow cytometry displayed internalization CC-loaded effective endosomal escape Remarkably, loaded saporin, ribosome inactivating protein, exhibited significantly enhanced apoptotic activity cells low IC50 12.2 nM. These have appeared as simple multifunctional platform delivery.

Language: Английский

---

Active Cellular and Subcellular Targeting of Nanoparticles for Drug Delivery

Pharmaceutics, Journal Year: 2019, Volume and Issue: 11(10), P. 543 - 543

Published: Oct. 18, 2019

Nanoparticle (NP)-mediated drug delivery (NMDD) for active targeting of diseases is a primary goal nanomedicine. NPs have much to offer in overcoming the limitations traditional approaches, including off-target toxicity and need administration repetitive doses. In last decade, one main foci NMDD has been realization NP-mediated formulations targeted diseased tissues, with an emphasis on cellular subcellular targeting. Advances this front included intricate design NP-drug constructs navigate through biological barriers, overcome multidrug resistance (MDR), decrease side effects, improve overall efficacy. review, we survey advancements over five years, highlighting how various designed achieve improved therapeutic outcomes critical cancer, rheumatoid arthritis, Alzheimer’s disease. We conclude current clinical trial landscape envision field will progress near future.

Language: Английский

---

Nanocomposites as biomolecules delivery agents in nanomedicine

Journal of Nanobiotechnology, Journal Year: 2019, Volume and Issue: 17(1)

Published: April 3, 2019

Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess unique physical and chemical properties associated with a size range between 1 100 nm. Their nano-sized dimensions, which in the same as those vital biomolecules, such antibodies, membrane receptors, nucleic acids, proteins, allow them to interact different structures within living organisms. Because these features, numerous nanoparticles used medicine delivery agents for biomolecules. However, off-target drug can cause serious side effects normal tissues organs. Considering this issue, it is essential develop bioengineering strategies significantly reduce systemic toxicity improve therapeutic effect. In contrast passive delivery, nanosystems enable obtain enhanced efficacy, decrease possibility resistance, "conventional" therapy cancers. The present review provides an overview most recent (mostly last 3 years) achievements related biomolecules targeting capabilities highly diverse nanoparticles. These include monoclonal receptor-specific peptides deoxyribonucleic ribonucleic [DNA/RNA] aptamers, small molecules folates, even vitamins carbohydrates.

Language: Английский

---