2D MXene Biomaterials for Catalytic Medical Applications

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(21)

Published: July 10, 2024

Abstract In recent years, two‐dimensional transition metal carbides, nitrides, and carbonitrides, termed as MXenes, have been widely applied in energy storage, photocatalysis biomedicine owing to their unique physicochemical properties of large specific surface area, high electrical conductivity, excellent optical performance, good stability, etc. Moreover, due strong light absorption capacity the first second near‐infrared bio‐window, ability being simply functionalized with multiple organic/inorganic materials, MXene biomaterials shown great potential field catalytic therapy. This review will summarize common mechanism latest applications medicine such tumor therapy, antibacterial anti‐inflammatory, present current challenges opportunities clinical translation for future development promote advancement medicine.

Language: Английский

Relief of Biofilm Hypoxia: A Synergistic Approach with Cyanobacteria and Chlorin e6-Loaded Nanoparticles

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Photodynamic therapy (PDT) involves the use of photosensitizers, oxygen, and light to generate reactive oxygen species (ROS) for effective destruction cancer cells or bacteria. However, in biofilm bacterial infections, presence hypoxia significantly reduces efficacy PDT. To address this issue, we have developed a synergistic approach wherein Synechococcus elongatus (PCC 7942), cyanobacteria are loaded into sodium alginate hydrogel, chlorin e6 (Ce6) is conjugated with mesoporous silica nanoparticles (Ce6-MSNs). Cyanobacteria photosynthetic organisms capable releasing when exposed 660 nm light. This property facilitates production ROS by Ce6-MSNs, even hypoxic conditions, potentially enabling more PDT against MRSA planktonic bacteria biofilm. Our results demonstrate that system can maintain generation capacity test period 30 days, thereby enhancing under conditions. In summary, innovative combines cyanobacteria's Ce6-MSNs' capabilities challenge infections. The promising suggest its potential improving including drug-resistant strains such as MRSA. Graphical

Language: Английский

Multifunctional Ti₃C₂@PDA/CuO₂ Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Language: Английский