Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155747 - 155747
Published: Nov. 28, 2024
Language: Английский
Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(4)
Published: June 27, 2024
Abstract Cancer stem cells (CSCs) are a small subset of tumor cells, efficient in self‐renewal within the and also play vital role cancer resistance metastasis. Recent research has focused on exosomes, tiny subpopulation extracellular vesicles (EVs), known for their intercellular communication, significantly contributing to development metastasis (Tumor derived exosomes‐TEXs). These exosomes complicate treatment by promoting CSC formation developing drug therapeutic resistance. This article explores how tumor‐derived impact survival, proliferation, therapies, leading recurrence. In microenvironment (TME), facilitate growth Targeting could disrupt communication improve efficacy. Current studies highlight CSCs progression Understanding exosome‐based cell‐to‐cell opens new horizon therapeutics development.
Language: Английский
Citations
1
Clinical and Translational Discovery, Journal Year: 2024, Volume and Issue: 4(3)
Published: June 1, 2024
Abstract Extracellular vesicles (EVs), including exosomes, ectosomes, and apoptotic bodies, play crucial roles in cellular communication disease processes. Among these, exosomes are particularly significant for diagnosing, cancer (which remains a leading cause of death worldwide). Exosomes offer cutting‐edge approaches nanomedicine, biomarkers investigation (diagnosis prognosis), therapeutic. found several body fluids (Blood, plasma, serum, urine, saliva, sweat, CSF, tear). It transforms the liquid biopsy method with more specificity. Exosome‐based sensor (electrochemical aptamer‐based) developers were effective sensitive scanning. Therapeutic prospect stem cell‐derived plant‐derived become promising. Due to its non‐toxicity (depending on source), non‐immunogenic, biocompatibility ability cross biological membranes. an exciting nano‐drug transporter Current time‐modified support development effective, efficient, cost‐effective nanomedicine against cancer. Advanced nanotechnology exosome combining (single profiling, barcoding)transform theranostics approaches. introduce new horizon nanomedicine.
Language: Английский
Citations
0
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 22, 2024
Acute pulmonary embolism (APE) is a life-threatening complication that primarily caused by the migration of deep vein thrombosis to lungs. However, current drug treatments have limited efficacy and can lead lung ischemia–reperfusion injury (LIRI) after thrombolysis. Inhaled nitric oxide has shown potential for APE therapy, but its clinical feasibility still uncertain. In this study, (NO) was directly encapsulated nanobubbles form NO-loaded (NanoNO) as treatment subsequent LIRI. NanoNO, with size 219.27 ± 2.42 nm polydispersity index 0.17, could encapsulate up 1.1 mM NO. LIRI cell model, NanoNO increased NO concentration superoxide dismutase (SOD) enzyme activities while reducing reactive oxygen species (ROS) malondialdehyde (MDA) levels (2.80-fold), leading decreased apoptosis. rabbit model APE, compared sodium nitroprusside (SNP, positive control) thrombolysis using blood gas analysis, angiography, echocardiography, hematoxylin–eosin staining. The results demonstrated more effective than SNP in thrombolysis, evidenced better ability remove clots, normalize arteries, relieve right ventricular (RV) dilatation. serum MDA, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) increasing SOD. Collectively, these findings highlight promising therapeutic approach mitigation
Language: Английский
Citations
0
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 266, P. 155747 - 155747
Published: Nov. 28, 2024
Language: Английский
Citations
0